Effect of Chronic Administration of a Synthetic Aromatic Retinoid (Ro 10-9359) on the Development of Lung Squamous Metaplasia and Epidermoid Cancer in Rats
Since the first studies of Saffioti et al. (1) suggesting the preventive effect of high doses of vitamin A on squamous metaplasias of trachea and bronchis, several authors have used synthetic analogs of vitamin A, like retinoic acid, in chemoprevention and chemotherapy of tumors. Successful results were reported with skin (2) bladder (3) and mammary carcinogenesis (4). However for cancers of the respiratory tract the findings of Saffioti have not been confirmed in mice (5) hamsters (6) or rats (7). In our laboratory we have developed a model of lung carcinogenesis by using the combined effect of inhalation of radioactive particles and intratracheal instillation of benzopyrene. This model was used to examine the preventive and curative effect of a synthetic aromatic retinoid (Ro 10.9359) on the induction of development of metaplasia and epidermoid lung cancer. For this purpose, the compound was administered chronically at various times after carcinogen exposure.
KeywordsLung Tumor Squamous Metaplasia Intratracheal Instillation Mammary Carcinogenesis Lung Carcinogenesis
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