Interferons: Several Questions and Few Answers

  • William E. StewartII
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 166)


A number of clinical trials are presently ongoing to test the utility of interferons (IFNs) as antiviral and antitumor agents; several tabulations of these have appeared and, in sum, these show that more trials are warranted (Reviewed in Ref. 1). Rather than reiterate these spotty pilot studies, I should like to consider the few key questions which should focus on the status of IFN trials.


Osteogenic Sarcoma Biological Response Modifier Condyloma Acuminata Acute Lymphatic Leukemia Human Leukocyte Interferon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Stewart II, W. E. 1981. The Interferon System, 2nd Edition, Springer-Verlag, Vienna-New York.CrossRefGoogle Scholar
  2. 2.
    Gresser, I. 1972. Antitumor effect of interferon. Adv. Cancer Res. 16: 97–140.PubMedCrossRefGoogle Scholar
  3. 3.
    Strander, H., K. Cantell, P. A. Jakobsson, U. Nilsonne, G. Soderberg. 1974. Exogenous interferon therapy of osteogenic sarcoma. Acta Orthop. Scand. 45: 958–967.Google Scholar
  4. 4.
    Strander, H., K. Cantell, S. Ingimarsson, P. A. Jakobsson, U. Nilsonne, G. Soderberg. 1977. Interferon treatment of osteogenic sarcoma: a clinical trial. Fogarty Intern. Center Proc. 28: 377–380.Google Scholar
  5. 5.
    Strander, H. 1977. Interferons: anti-neoplastic drugs? Blut 35: 277–288.PubMedCrossRefGoogle Scholar
  6. 6.
    Merigan, T. C., K. Skoro, J. H. Breeden, R. Levy, S. A. Rossenberg. 1978. Preliminary observations on the effect of human leukocyte interferon in non-Hodgkins lymphoma. N. Engl. J. Med. 299: 1444–1453.CrossRefGoogle Scholar
  7. 7.
    Hill, N. O., L. Loeb, A. Pardue. 1978. Leukocyte interferon production and its effectiveness in acute lymphatic leukemia. J. Clin. Hematol. Oncol. 8: 66–70.Google Scholar
  8. 8.
    Ikic, D., Z. Markic, V. Orelic, B. Rode, P. Nola, K. Smudj, M. Knezevic and D. Jusic. 1981. Application of human leukocyte interferon in patients with urinary bladder papillomatosis, breast cancer and melanoma. Lancet I: 1022–1024.Google Scholar
  9. 9.
    Stewart II, W. E., I. Gresser, M. G. Tovey, M. T. Bandu and S. LeGoff. 1976. Identification of the cell-multiplication-inhibitory factors in interferon preparations as interferons. Nature 262: 300–303.PubMedCrossRefGoogle Scholar
  10. 10.
    Gresser, I., C. Maury and D. Brouty-Boye. 1972. On the mechanism of the antitumor effect of interferon in mice. Nature 239: 167–168.PubMedCrossRefGoogle Scholar
  11. 11.
    Gresser, I., M. T. Bandu and D. Brouty-Boye. 1974. Interferon and cell division. IX. Interferon-resistant L1210 cells: characteristics and origin. J. Natl. Cancer Inst. 52: 553–559.PubMedGoogle Scholar
  12. 12.
    Trinchieri, G., D. Santoli and H. Koprowski. 1978. Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins. J. Immunol. 120: 1849–1860.PubMedGoogle Scholar
  13. 13.
    Lockart, R. Z. 1964. The necessity for cellular RNA and protein synthesis for viral inhibition from interferon. Biochem. Biophys. Res. Commun. 15: 513–518.CrossRefGoogle Scholar
  14. 14.
    Chany, C., F. Fournier and S. Rousset. 1971. Potentiation of the antiviral activity of interferon by actinomycin D. Nature New Biology 230: 113–114.PubMedCrossRefGoogle Scholar
  15. 15.
    Scott, G. M., J. Wallace, D. A. J. Tyrreu, K. Cantell, D. S. Sechar and W. E. Stewart II. 1982. An interim report on studies on the toxic effects of human leukocyte-derived interferon-alpha. J. Interferon Res. 2: 127–130.PubMedCrossRefGoogle Scholar
  16. 16.
    Merigan, T. C. 1981. Personal couuuunication.Google Scholar
  17. 17.
    Petralli, J. K., T. C. Merigan and J. R. Wilbur. 1965. Circulating interferon after measles vaccination. New Engl. J. Med. 273: 198–201.Google Scholar
  18. 18.
    Stewart II, W. E. and J. Desmyter. 1975. Molecular heterogeneity of human leukocyte interferon. Virology 67: 68–78.PubMedCrossRefGoogle Scholar
  19. 19.
    Streuli, M., A. Hau, W. Bou, W. E. Stewart II., S. Nagata and C. Weissmann. 1981. Target cell specificity of two species of human interferon produced in E. coli and hybrid molecules derived from them. Proc. Nat. Acad. Sci. USA. 78: 2848–2852.PubMedCrossRefGoogle Scholar
  20. 20.
    Stewart II, W. E., P. DeSomer, V. G. Edy, K. Paucker, K. Berg and C. A. Ogburn. 1975. Distinct molecular species of human interferons: leukocyte and fibroblast. J. Gen. Virol. 26: 327–333.CrossRefGoogle Scholar
  21. 21.
    Pazin G. J., M. Ho, H. Hoverkos, J. A. Armstrong, M. Breinig, H. Wechsler, A. Arvin, T. Merigan and K. Panteu. 1982. Effects of interferon-alpha on human warts. J. Interferon Res. 2: 235–244.PubMedCrossRefGoogle Scholar
  22. 22.
    Strander, H. 1982. 3rd Annual International Congress for Interferon Research, Miami, Florida, November 1982.Google Scholar
  23. 23.
    Strander, H. 1977. Administration of exogenous interferon into patients with neoplastic diseases. Fifth Aharon KatzirKatchalsky Conference. Rehovot, Israel.Google Scholar
  24. 24.
    Borden, E. and collaborators. 1981. Second Annual International Congress for Interferon Research, San Francisco, California, October 1981.Google Scholar
  25. 25.
    Krown, S. 1982. 3rd Annual International Congress for Interferon Research. Miami, Florida, November 1982.Google Scholar
  26. 26.
    Nietheimmer, D. 1981. Personal communication.Google Scholar
  27. 27.
    Ikic, D., S. Smerdel, E. Soos and D. Jusic. 1975. Preliminary study of the use of interferon on condylomata acuminata in women, pp. 223–225. Proc. Symp. Clin. Use of Interferons. Yugoslay. Acad. Sci.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • William E. StewartII
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

Personalised recommendations