Phospholipids pp 219-231 | Cite as

Phospholipids and Choline Deficiency

  • Steven H. Zeisel


Lecithin (phosphatidylcholine; PtdCho) is the major phospholipid constituent of most membranes, and it is vital to the normal function of every cell and organ. PtdCho is synthesized from choline in all organs29,30. Much of this choline comes from the diet. PtdCho, in foods such as liver, eggs, soybeans and peanuts, is the most important source of choline in the human diet29. This dietary choline interacts with methionine and folate metabolism so that changes in the availability of choline alter biological methylation reactions. Choline is also used by tissues to make acetylcholine. This chapter will focus on PtdCho as a source of choline in the diet, and upon the biological consequences of diminished availability of choline.


Deficient Group Choline Deficiency Choline Deficient Diet Choline Supplementation Dietary Choline 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Steven H. Zeisel
    • 1
  1. 1.Nutrient Metabolism Laboratory Departments of Pathology and PediatricsBoston University School of MedicineBostonUSA

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