Effect of Malnutrition on Brain Growth-Histological and Autoradiographical Studies

  • Tomoichi Kusunoki
Part of the Nutrition and Food Science book series (NFS, volume 3)


There is increasing evidence that infants who are born with intrauterine growth retardation have a higher incidence of central nervous system problems than infants born with appropriate growth for gestational age. This evidence has also been confirmed by our retrospective study on the causes of microcephaly, in which as many as 36 cases of 140 microcephalies, I mean, 26% were the products of intrauterine growth retardation. Severe maternal toxemia, metabolic and endocrinoligic disorders, and chronic renal disease of the mother, placental anomalies, and fetal infections are the main etiologic factors of intrauterine growth retardation. Most of these factors also often give rise to nutritional deprivation for the infant either directly or indirectly.


Granule Cell Cerebellar Cortex Dendrite Growth Intrauterine Growth Retardation External Granular Layer 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Tomoichi Kusunoki
    • 1
  1. 1.Kyoto Prefectural Univ. of MedicineKyotoJapan

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