Abstract
The hypocholesterolemic action of polyunsaturated vegetable fats as a replacement for animal fat in the diet of both man and experimental animals has been repeatedly demonstrated over the last 25 years1–5. Studies by numerous investigators have shown this effect to be attributable to three main factors: 1) a decrease in saturated fat; 2) a decrease in dietary cholesterol and 3) an increase in polyunsaturated fat particularly linoleic acid. This paper will review briefly the efficacy and mechanisms by which dietary polyunsaturated fats lower blood lipids in man as well as the rationale for current dietary recommendations for the use of polyunsaturated fat for the prevention of coronary heart disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ahrens, E.H., Jr., H. Hirsch, W. Insull, Jr., T.T. Tsaltas, T. Blomstrand and M.L. Peterson, Dietary control of serum lipids in relation to atherosclerosis. J. Am. Med. Assoc. 164: 1905–1914, 1957.
Bronte-Stewart, B., A. Antonis, L. Eales and F. Brock, Effects of feeding different fats on serum cholesterol level. Lancet I: 521–526, 1956.
Keys, A., J.T. Anderson and F. Grande, Prediction of serum cholesterol responses of man to changes in fats in the diet. Lancet II: 959–966, 1957.
Malmros, H., G. Wigand, The effect. on serum cholesterol of diets containing different fats. Lancet II: 1–8, 1957.
Beveridge, J.M.R., W.F. Connell and G.A. Mayer, Dietary factors affecting the level of plasma cholesterol in humans: the role of fat. Can. J. Biochem. Physiol. 34: 441–455, 1956.
Keys, A., Coronary heart disease in seven countries. Circulation 41, 42, Suppl. 1: I-1–211, 1970.
Friend, B., Nutrients in United States food supply. A review of trends 1909–1913 to 1965. Am. J. Clin. Nutr. 20: 907–914, 1967.
Connor, W.E., D. T. Witiak, D.B. Stone and M.L. Armstrong, Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition. J. Clin. Invest. 48: 1363–1375, 1969.
Hegsted, D.M., R.B. McGandy, M.L. Myers and F.J. Stare, Quantitative effects of dietary fat on serum cholesterol in man. Am. J. Clin. Nutr. 17: 281–295, 1965.
Ahrens, E.M., Jr., W. Insull, Jr., J. Hirsch, W. Stoffel, M. L. Peterson, J.W. Farquhar, T. Miller and H.J. Thomasson: The effect on human serum lipids of a dietary fat highly unsaturated but poor in essential fatty acids. Lancet I: 115–122, 1959.
Mattson, F.H., E. J. Hollenbach and A.M. Kligman, Effect of hydrogenated fat on the plasma cholesterol and triglyceride levels of man. Am. J. Clin. Nutr. 28: 726–731, 1975.
Keys, A., J.T. Anderson and F. Grande, Effect on serum cholesterol in man of mono-ene fatty acid (oleic acid) in the diet. Proc. Soc. Exp. Biol. Med. 98: 381–387, 1958.
McGill, H.C., Jr., Atherosclerosis: problems in pathogenesis. In: “Atherosclerosis Reviews”, Gotto, A.M. and R. Paoletti (eds.), Raven Press, New York, 1977, p. 27–65.
Frerichs, R.R., S.R. Srinivasan, L.S. Webber et al., Serum cholesterol and triglyceride levels in 3446 children from a biracial community. The Bogalusa Heart Study. Circulation 54: 302–309, 1976.
Lauer, R.M., W.E. Connor, P.E. Leaverton, M.A. Reiter, and W.R. Clarke, Coronary heart disease risk factors in school children: The Muscatine Study. Pediatr. 36: 697–706, 1975.
Connor, W.E., M.T. Cerqueira, R.W. Connor, R.B. Wallace, M.R. Malinow, and H.R. Casdorph, The plasma lipids, lipoproteins, and diet of the Tarahumara Indians of Mexico. Am. J. Clin. Nutr., in press, 1978.
Stein, E.A., D. Mendelsohn, I. Bersohn et al., Lowering of plasma cholesterol levels in free-living adolescent males: use of natural and synthetic polyunsaturated foods to provide balanced fat diets. Am. J. Clin. Nutr. 28: 1204–1216, 1975.
McGandy, R.S., B. Hall, C. Ford and F.J. Stare: Dietary regulation of blood cholesterol in adolescent males. A pilot study. Am. J. Clin. Nutr. 25: 61–70, 1972.
Glueck, C.H. and P. O. Kwiterovich, The lipid hypothesis, genetic basis. Arch. Surg. 11: 35–44, 1978.
Friedman, G., and S.J. Goldberg: An evaluation of the safety of a low saturated diet, low cholesterol diet, beginning in infancy. Pediatrics 58: 655–657, 1976.
Vergroesen, A.J., Dietary fat and cardiovascular disease: possible modes of action of linoleic acid. Proc. Nutr. Soc. 31: 323–329, 1972.
Leren, P., Prevention of coronary heart disease by diet. Postr. Med. J. 51 (Suppl. 8) 44–46, 1975.
Dayton, S., M.L. Pearce, S. Hashimoto et al., A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation 40 (Suppl. II): 1, 1969.
Miettinen, M., O. Turpeinen, M.J. Karvonen et al., Effect of cholesterol lowering diet in mortality from coronary heart disease and other causes. Lancet 2: 835–838, 1972.
Leren, P., Effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. Acta Med. Scand. 466: 5–92 (Suppl.), 1966.
National Diet-Heart Study. Final report. American Heart Association Monograph 48, Circulation 37, Suppl. 1, 1968.
Frantz, I.D., E.A. Dawson, K. Kuba et al., The Minnesota coronary survey: Effect of diet on cardiovascular events and deaths. Circulation 41 (Suppl. II) 2–4, 1975.
Glueck, C.J., F. Mattson and E.L. Bierman: Diet and coronary heart disease: another view. N. Eng. J. Med. 298: 1471–1473, 1978.
Jaganathan, S.N., W.E. Connor, W.H. Baker and A.K. Bhattacharyya: The turnover of cholesterol in human atherosclerotic arteries. J. Clin. Invest. 54: 366–377, 1974.
Armstrong, M.L., E.D. Warner and W.E. Connor, Regression of coronary atheromatosis in Rhesus monkeys. Circ. Res. 27: 59–67, 1970.
Blankenhorn, D.H., S.H. Brooks, R.H. Selzer and R. Barndt, Jr., The rate of atherosclerosis change during treatment of hyperlipoproteinemia. Circulation 57: 355–361, 1978.
Castelli, Gordon T., M.C. Hjortland, W.B. Kannel and T.R. Dawber, High Density Lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 62: 707–714, 1977.
Carlson, L.A. and L.E. Bottiger: Ischemic heart disease in relation to fasting values of plasma triglyceride and cholesterol. Lancet I: 865–868, 1972.
Durrington, P.N., C.H. Bolton, M. Hartog, R. Angelinetta, P. Emmett and S. Furniss, The effect of a low cholesterol, high polyunsaturated diet on serum lipid levels, apoprotein B levels and triglyceride fatty acid composition. Atherosclerosis 27: 465–475, 1977.
Chait, A., A. Onitiri, A. Nicoll, E. Rabaya, J. Davies and B. Lewis, Reduction of serum triglyceride levels by polyunsaturated fat. Atherosclerosis 20: 347–364, 1974.
Grundy, S.M., Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia. J. Clin. Invest. 55: 269–282, 1975.
Shepherd, J., C.J. Packard, J.R. Patsch, A.M. Gotto, Jr., and O.D. Taunton, Effects of dietary polyunsaturated and saturated fat on the properties of high density lipoproteins and the metabolism of Apolipoprotein A-I. J. Clin. Invest. 61: 1582–1592, 1978.
Burslem, J., G. Schoenfeld, M.A. Howald, S.W. Weideman and J.P. Miller, Plasma apoprotein and lipoprotein lipid levels in vegetarians. Metabolism 27: 711–719, 1978.
Jackson, R.L., O.D. Taunton, J.D. Morrisett and A.M. Lotto Jr., The role of dietary polyunsaturated fat in lowering blood cholesterol in man. Circ. Res. 42: 447–453, 1978.
Grundy, S.M. and E.H. Ahrens, The effects of unsaturated dietary fats on absorption excretion systhesis and distribution of cholesterol in man. J. Clin. Invest. 49: 1135–1152, 1970.
Nestel, P.J., N. Havenstein, Y. Hoimna, T.W. Scott and L.J. Cook, Increased sterol excretion with polyunsaturated fat high cholesterol diets. Metabolism 24: 189–198, 1975.
Bieberdorf, F.A. and J.D. Wilson, Studies on the mechanism of action of unsatuarted fats on cholesterol metabolism in the rabbit. J. Clin. Invest. 44: 1834–1841, 1965.
Nestel, P.J., N. Havenstein, T.W. Scott and L.J. Cook: Polyunsaturated ruminant fats and cholesterol metabolism in man. Aust. N.Z. J. Med. 4: 497–501, 1974.
Frantz, I.D. and J.B. Carey, Cholesterol content of human liver after feeding corn oil and hydrogenated coconut oil. Proc. Soc. Exp. Biol. Med. 106: 800–801, 1961.
Sigurdsson, G., A. Nicholl and B. Lewis, Conversion of very low density lipoprotein to low density lipoprotein. A metabolic study of apoprotein B kinetics in human subjects. J. Clin. Invest. 56: 1481–1490, 1975.
Illingworth, D.R., Metabolism of lipoproteins in nonhuman primates. Studies on the origin of low density lipoprotein apoprotein in the plasma of the squirrel monkey. Biochim. Biophys. Acta 388–38–51, 1975.
Turner, J.D., R. Monell and W.V. Brown, Heterogenous responses to polyunsaturated fat in low density lipoprotein turnover in hyperlipoproteinemia. Circ. 54: II - 4, 1976.
Yeshurun, D., A.M. Lotto, Jr., and 0.D. Taunton, Effects of polyunsaturated versus saturated fat on LDL metabolism in normal subjects. Clin. Res. 24 (3) 373A, 1976.
Bangdade, J.D., W.R. Hazzard and J. Carlin, Effect of unsaturated dietary fat on plasma lipoprotein lipase activity in normal and hyperlipidemic states. Metabolism 19: 1020–1025, 1970.
Sturdevant, R.A.L., M. L. Pearce and S. Dayton, Increased prevalence of cholelithiasis in men ingesting a serum cholesterol lowering diet. N. Eng. J. Med. 288: 24–27, 1973.
Pearce, M.L., and S. Dayton, Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet I: 464–467, 1971.
Ederer, F., P. Leren, O. Turpernen and I.D. Frantz, Jr., Cancer among men on cholesterol lowering diets. Lancet II: 203–206, 1971.
United States National Center for Health Statistics. Vital and Health Statistics Ser. 11 No. 202. A comparison of levels of serum cholesterol of adults 18–74 years of age in the United States in 1960–1962 and 1971–1974. Washington DC, Government Printing Office, 1977.
Walker, W.J., Changing United States life-style and declining vascular mortality: cause or coincidence? N. Eng. J. Med. 297: 163–165, 1977.
Pearson, A.M., Some factors that may alter consumption of animal products. J. Am. Diet. Assoc. 69: 522–530, 1976.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer Science+Business Media New York
About this chapter
Cite this chapter
Illingworth, D.R., Connor, W.E. (1980). Present Status of Polyunsaturated Fats in the Prevention of Cardiovascular Disease. In: Santos, W., Lopes, N., Barbosa, J.J., Chaves, D., Valente, J.C. (eds) Nutritional Biochemistry and Pathology. Nutrition and Food Science, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1349-7_46
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1349-7_46
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1351-0
Online ISBN: 978-1-4757-1349-7
eBook Packages: Springer Book Archive