The GABAA Receptor Complex: Is it a Locus of Action for Inhalation Anesthetics?

  • Eric J. Moody
  • Herman J. C. Yeh
  • Phil Skolnick


The mechanism(s) by which chemically diverse compounds produce general anesthesia (i.e., reversible unconsciousness) remains one of the enigmas of modern pharmacology despite intensive investigation for almost a century. While the structural diversity of general anesthetics (which range from barbiturates, alcohols and steroids to gases) has complicated the search for a common target site, the physical characteristics (high vapor pressure, low solubility in aqueous media and low potency) of commonly used inhalation agents such as halothane renders many pharmacological, neurochemical and electrophysiological approaches problematic.


GABAA Receptor General Anesthetic Inverse Agonist Inhalation Anesthetic Inhalation Agent 


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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Eric J. Moody
  • Herman J. C. Yeh
  • Phil Skolnick

There are no affiliations available

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