Neuroendocrine Concomitants of Alcohol Reinforcement

  • Jack H. Mendelson
  • Nancy K. Mello
  • Scott E. Lukas
  • Siew K. Teoh
  • William R. Phipps
  • James Ellingboe
  • Isaac Schiff
  • Susan Palmieri


The specific neural mechanisms underlying alcohol-induced changes in mood and feeling states are unknown. Although experimental animal studies have shown that many biologic processes in the brain are affected by ethanol, it appears unlikely that any single neurochemical or neurophysiologic system uniquely determines its reinforcing properties. At present, we postulate that multiple physiological, psychological and sociocultural factors enhance or reduce the probability for initiation and perpetuation of alcohol abuse by humans.


Ethanol Level Gonadotropin Stimulation Bioi Psychiatry Stud Alcohol Plasma Estradiol Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Alterman AL, Gottheil C, Crawford DH (1975): Mood changes in an alcoholism treatment program based on drinking decisions. Am J Psychiatry 132:1032–1037Google Scholar
  2. Barnes DM (1986): Steroids may influence changes in mood. Science 232:1344–1345CrossRefGoogle Scholar
  3. Bonn J, Fehm-Wolfsdorf G, Schiebe M, Birbaumer N, Fehm HL, Voight KH (1985): An ACTH 4–9 analog impairs selective attention in man. Life Sci 36:2117–2125CrossRefGoogle Scholar
  4. Bonn J, Fehm-Wolfsdorf G, Schiebe M, Rockstroh B, Fehm HL, Voight KH (1984): Dishabituating effects of an ACTH 4–9 analog in a vigilance task. Pharmacol Biochem Behav 21:513–519CrossRefGoogle Scholar
  5. Brown BB (1970): Recognition of aspects of consciousness through association with EEG alpha activity represented by a light signal. Psychophysiol 6:442–452CrossRefGoogle Scholar
  6. Cicero TJ (1980): Common mechanisms underlying the effects of ethanol and narcotics on neuroendocrine function. In: Advances in Substance Abuse, Behavioral and Biological Research, vol. 1. NK Mello, ed. Greenwich, Conn: JAI Press, Inc, pp 201–254Google Scholar
  7. Cicero TJ (1981): Neuroendocrinological effects of alcohol. Ann Rev Med 32:123–142CrossRefGoogle Scholar
  8. Cronholm T, Sjovall J (1968): Effect of ethanol on the concentrations of solvolyzable plasma steroids. Biochem Biophys Acta 152:233–236CrossRefGoogle Scholar
  9. Cronholm T, Sj ovall J, Sj ovall K (1969): Ethanol induced increase of the ratio between hydroxy-and ketosteroids in human pregnancy plasma. Steroids 13:671–678CrossRefGoogle Scholar
  10. Davis PA, Gibbs FA, Davis H, Jetter WW, Trowbridge LS (1941): Effects of alcohol upon electroencephalogram. Q J Stud Alcohol 1:626–637Google Scholar
  11. Docter RF, Naitoh P, Smith JC (1966): Electroencephalographic changes and vigilance behavior during experimentally induced intoxication with alcoholic subjects. Psychosom Med 28:605–615Google Scholar
  12. Ehlers CL (1986): EEG stability following corticotropin releasing factor in rats. Psychoneuroendocrinology 11:121–125CrossRefGoogle Scholar
  13. Engel GL, Rosenbaum M (1945): Delirium: electroencephalographic changes associated with acute alcoholic intoxication. Arch Neurol Psychiatry 53:44–50Google Scholar
  14. Forsander O, Raiha N, Sumalainen H (1958): Alkohol oxydation und bildung von acetoacetat in normaler und glykogenarmer intakter rattenleber. Hoppe Seyler. Z Physiol Chem 312:243–248CrossRefGoogle Scholar
  15. Gold PW, Loriaux DL, Roy A, Kling MA, Calabrese JR, Kellner CH, Nieman LK, Post RM, Pickar D, Gallucci W, Augerinos P, Paul S, Oldfield EH, Cutler GB, Chrousos GP (1986): Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease: pathophysiologic and diagnostic implications. N Eng J Med 314:1329–1335CrossRefGoogle Scholar
  16. Goldberg L (1943): Quantitative studies on alcohol tolerance in man. Acta Physiol Scand 5(Suppl. 16):1–128Google Scholar
  17. Holmberg G, Martens S (1955): Electroencephalographic changes in man correlated with blood alcohol concentration and some other conditions following standardized ingestion of alcohol. Q J Stud Alcohol 16:411–424Google Scholar
  18. Jasper HH (1958): The 10–20 electrode system of the International Federation. Electroenceph Clin Neurophysiol 10:371–375Google Scholar
  19. Jones BM (1973): Memory impairment on the ascending and descending limbs of the blood alcohol curve. J Abnorm Psychol 82:24–32CrossRefGoogle Scholar
  20. Kissin B, Schenker V, Schenker A (1959): The acute effects of ethyl alcohol and chlorpromazine on certain physiological functions in alcoholics. Q J Stud Alcohol 20:480–492Google Scholar
  21. Kissin B, Schenker V, Schenker AC (1960): The acute effect of ethanol ingestion on plasma and urinary 17-hydroxycorticoids in alcoholic subjects. Am J Med Sci 239:690–705CrossRefGoogle Scholar
  22. Lindsley D (1952): Psychological phenomena and the electroencephalogram. Electroenceph Clin Neurophysiol 4:443–456CrossRefGoogle Scholar
  23. Little SC, McAvoy M (1952): Electroencephalographic studies in alcoholism. Q J Stud Alcohol 13:9–15Google Scholar
  24. Lukas SE, Mendelson JH (1988): Electroencephalographic activity and plasma ACTH during ethanol-induced euphoria. Biol Psychiatry 23:141–148CrossRefGoogle Scholar
  25. Lukas SE, Mendelson JH, Benedikt RA (1986a): Instrumental analysis of ethanolinduced intoxication in human males. Psychopharmacol 89:8–13Google Scholar
  26. Lukas SE, Mendelson JH, Benedikt RA, Jones B (1986b): EEG alpha activity increases during transient episodes of ethanol-induced euphoria. Pharmacol Biochem Behav 25:889–895, 1986b.CrossRefGoogle Scholar
  27. Lukas SE, Mendelson JH, Benedikt RA, Jones B (1986c): EEG, physiologic and behavioral effects of ethanol administration. In: Problems of Drug Dependence, Harris LS, ed. 1985, NIDA Research Monograph No. 67. Washington, D.C.: U.S. Government Printing Office, pp 209–214Google Scholar
  28. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM (1986): Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004–1007CrossRefGoogle Scholar
  29. Matejcek M (1982): Vigilance and the EEG: Psychological, physiological and pharmacological aspects. In: EEG in Drug Research. WM Hermann, ed. Stuttgart: Gustav Fischer, pp 405–508Google Scholar
  30. Matousek M, Petersen I (1983): A method of assessing alertness fluctuations from EEG spectra. Electroenceph Clin Neurophysiol 55:108–113CrossRefGoogle Scholar
  31. McGuire MT, Mendelson JH, Stein S (1966): Comparative psychosocial studies of alcoholic and non-alcoholic subjects undergoing experimentally induced ethanol intoxication. Psychosom Med 28:13–26Google Scholar
  32. Mello NK (1972): Behavioral studies of alcoholism. In: The Biology of Alcoholism, vol. II, Physiology and Behavior. Kissin B, Begleiter H, eds. New York: Plenum Press, pp 219–291Google Scholar
  33. Mello NK (1988): Effects of alcohol abuse on reproductive function in women. In: Recent Developments in Alcoholism, vol. 6. Galanter M, ed. New York: Plenum Publishing Corp, pp 253–276CrossRefGoogle Scholar
  34. Mello NK, Mendelson JH (1978): Alcohol and human behavior. In: Handbook of Psychopharmacology, Section III, Chemistry, Pharmacology and Human Use, Iversen LL, Iversen SD, and Snyder, SH, eds. New York: Plenum Press, pp 235–317Google Scholar
  35. Mello NK, Mendelson JH, Teoh S (1989): Neuroendocrine consequences of alcohol abuse in women. In: Prenatal Abuse of Licit and Illicit Drugs. Hutchings DE, ed. New York: Ann NY Acad Sci 562:211–240Google Scholar
  36. Mendelson JH (1964): Experimentally induced chronic intoxication and withdrawal in alcoholics. Q J Stud Alcohol, Suppl. 2Google Scholar
  37. Mendelson JH (1970): Biological concomitants of alcoholism. N Engl J Med 283:24–32CrossRefGoogle Scholar
  38. Mendelson JH, Lukas SE, Mello NK, Amass L, Ellingboe J, Skupny A (1988): Acute alcohol effects on plasma estradiol levels in women. Psychopharmacol 94:464–467CrossRefGoogle Scholar
  39. Mendelson JH, McGuire M, Mello NK (1984): A new device for administering placebo alcohol. Alcohol 1:417–419CrossRefGoogle Scholar
  40. Mendelson JH, Mello NK, Cristofaro P, Ellingboe J, Skupny A, Palmieri SL, Benedikt R, Schiff I (1987): Alcohol effects on naloxone-stimulated luteinizing hormone, prolactin and estradiol in women. J Stud Alcohol 48:287–294Google Scholar
  41. Mendelson JH, Mello NK, Ellingboe J (1977): Effects of acute alcohol intake on pituitary gonadal hormones in normal males. J Pharmacol Exp Ther 202:676–682Google Scholar
  42. Mendelson JH, Mello NK, Ellingboe J (1981): Acute alcohol intake and pituitary gonadal hormones in normal human females. J Pharmacol Exp Ther 218:23–26Google Scholar
  43. Mendelson JH, Stein S (1966): Serum cortisol levels in alcoholic and nonalcoholic subjects during experimentally induced ethanol intoxication. Psychosom Med 28:616–626Google Scholar
  44. Murono EP, Fisher-Simpson V (1984): Ethanol directly increases dihydrotestosterone conversion to 5α-androstan-3β, 17β-diol and 5α-androstan-3α , 17β-diol in rat leydig cells. Biochem Biophys Res Commun 121:558–565CrossRefGoogle Scholar
  45. Murono EP, Fisher-Simpson V (1985): Ethanol directly stimulates dihydrotestosterone conversion to 5α-androstan-3α, 17β-diol and 5α-androstan-3α, 17β-diol in rat liver. Life Sci 36:1117–1124CrossRefGoogle Scholar
  46. Nathan PE, Titler NA, Lowenstein LM, Solomon P, Rossi AM (1970): Behavioral analysis of chronic alcoholism. Interaction of alcohol and human contact. Arch Gen Psychiatry 22:419–430CrossRefGoogle Scholar
  47. Noth RH, Walter Jr RM (1984): The effects of alcohol on the endocrine system. Med Clin North Am 68:133–146Google Scholar
  48. Otto E (1967): The effect of instructions influencing the level of alertness of the EEG activity. In: Mechanisms of Orienting Reaction in Man. Nedecky I, ed. Bratislava: Slovak Academy of Sciences Publishing House, pp 351–365Google Scholar
  49. Phipps WR, Lukas SE, Mendelson JH, Ellingboe J, Palmieri SL, Schiff I (1987): Acute ethanol administration enhances plasma testosterone levels following gonadotropin stimulation in men. Psychoneuroendocrinol 12:459–465CrossRefGoogle Scholar
  50. Redei E, Branch B, Taylor AN (1986): Abstracts of the First International Congress of Neuroendocrinology 293:98Google Scholar
  51. Teoh SK, Mendelson JH, Mello NK, Skupny A (1988): Alcohol effects on naltrexone-induced stimulation of pituitary, adrenal and gonadal hormones during the early follicular phase of the menstrual cycle. J Clin Endocrinol Metab 66:1181–1186CrossRefGoogle Scholar
  52. Tallarida RJ, Murray RB (1981): Manual of Pharmacologic Calculations. New York: Springer-VerlagCrossRefGoogle Scholar
  53. Van Thiel DH, Gavaler JS, Cobb CF, Chiao Y-B (1982): Effects of ethanol upon the hypothalamic pituitary gonadal axis. In: The Endocrines and the Liver. Langer M, Chiandussi L, Chopra IJ, and Martini L, eds. New York: Academic Press, pp117–134Google Scholar
  54. Van Thiel DH, Tarter RE, Rosenblum E, Gavaler JS (1988): Ethanol, its metabolism and gonadal effects: does sex make a difference? In: Advances in Alcohol and Substance Abuse: Alcohol Research from Bench to Bedside. Stimmel B, ed. New York: Haworth Press pp 131–169Google Scholar
  55. Varga B, Nagy T (1960): Analysis of alpha-rhythms in the electroencephalogram of alcoholics. Electroenceph Clin Neurophysiol 12:933CrossRefGoogle Scholar
  56. Wallace RK (1970): Physiological effects of transcendental meditation. Science 167:1751–1754CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Jack H. Mendelson
  • Nancy K. Mello
  • Scott E. Lukas
  • Siew K. Teoh
  • William R. Phipps
  • James Ellingboe
  • Isaac Schiff
  • Susan Palmieri

There are no affiliations available

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