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Extracellular Keratins: An Update

  • Robert D. Cardiff
  • Shoichiro Taniuchi
  • Daer He

Abstract

Four years ago we announced the production of a series of monoclonal antibodies which react with the major epithelial keratins of MCF7 and other breast cancer cell lines (1). One of the antibodies, UCD/PR 10.11, has proven to be an excellent reagent, when used in the immunoperoxidase technique, for the diagnosis of epithelial malignancies (2). UCD/PR 10.11 reacts with CK 8 and 18. It has a superb signal-to-noise ratio in staining almost all simple epithelia and is thought by some to be one of the best diagnostic monoclonal anti-keratin available for immunopathology (3). It is now commercially available through Triton Biosciences, Inc.

Keywords

Breast Cancer Bladder Cancer MCF7 Cell Transitional Cell Carcinoma Benign Breast Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Robert D. Cardiff
    • 1
  • Shoichiro Taniuchi
    • 1
  • Daer He
    • 1
  1. 1.Department of PathologyUniversity of California School of MedicineDavisUSA

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