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Free Radicals and Myocardial Ischemia

The Role of Xanthine Oxidase
  • Joe M. McCord
  • Ranjan S. Roy
  • Stephen W. Schaffer
Part of the Advances in Myocardiology book series (ADMY)

Abstract

Recent studies have established a major role for oxygen-derived free radicals in post ischemic tissue injury to the intestine. During ischemia, there appears to be a calcium-triggered, protease- de pen dent conversion of the native xanthine dehydrogenase to a superoxide-producing xanthine oxidase. The catabolic degradation of ATP during ischemia provides an oxidizable substrate, hypoxanthine. On reperfusion, molecular oxygen is resupplied and a burst of superoxide production ensues, resulting in extensive tissue damage. The same mechanism appears to occur in myocardial ischemia. Xanthine dehydrogenase rapidly converts to the oxidase during nonperfusion in the rat heart. In the isolated perfused working rat heart model, 40 min of anoxia followed by reoxygenation results in substantial release of creatine kinase. The release of creatine kinase is blocked almost completely by pretreatment of the rats with allopurinol, a specific inhibitor of xanthine oxidase.

Keywords

Creatine Kinase Xanthine Oxidase Xanthine Dehydrogenase Superoxide Free Radical Enzyme Xanthine Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Joe M. McCord
    • 1
  • Ranjan S. Roy
    • 1
  • Stephen W. Schaffer
    • 2
  1. 1.Department of Biochemistry, College of MedicineUniversity of South AlabamaMobileUSA
  2. 2.Department of Pharmacology, College of MedicineUniversity of South AlabamaMobileUSA

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