Developing an Invertebrate Model for Chemical Carcinogenesis: Metabolic Activation of Carcinogens

  • Robert S. Anderson
Part of the Comparative Pathobiology book series (CPATH, volume 4)


It has been reported occasionally that the incidence of neoplasia among invertebrate animals is lower than that seen among mammalian species. It is unclear if this is true or if this is a result of lack of data, or some unique feature of invertebrate biology. Since many chemical carcinogens require metabolic activation before they can express their biological activities, lack of the enzymes which mediate these reactions could supply a basis to support the theory that invertebrates are resistant to cancer. Therefore, this laboratory initiated comparative studies of aryl hydrocarbon hydroxylase (AHH) activity in lower animals using benzo [a] pyrene (BP) as substrate.


Smooth Endoplasmic Reticulum Crassostrea Virginica Chemical Carcinogenesis Aryl Hydrocarbon Hydroxylase Invertebrate Model 


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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Robert S. Anderson
    • 1
  1. 1.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

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