Developing an Invertebrate Model for Chemical Carcinogenesis: Metabolic Activation of Carcinogens
It has been reported occasionally that the incidence of neoplasia among invertebrate animals is lower than that seen among mammalian species. It is unclear if this is true or if this is a result of lack of data, or some unique feature of invertebrate biology. Since many chemical carcinogens require metabolic activation before they can express their biological activities, lack of the enzymes which mediate these reactions could supply a basis to support the theory that invertebrates are resistant to cancer. Therefore, this laboratory initiated comparative studies of aryl hydrocarbon hydroxylase (AHH) activity in lower animals using benzo [a] pyrene (BP) as substrate.
KeywordsSmooth Endoplasmic Reticulum Crassostrea Virginica Chemical Carcinogenesis Aryl Hydrocarbon Hydroxylase Invertebrate Model
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- Brattsten, L. B. and Wilkinson, C. F. (1973). A microsomal enzyme inhibitor in the gut contents of the house cricket (Acheta domesticus) . Comp. Biochem. Physiol., 45B, 59–70.Google Scholar
- Brown, R. S., Wolke, R. E., Brown, C. W. and Saila, S. B. (1977) . Hydrocarbon pollution and the prevalence of neoplasia in feral soft-shell clams, Mya arenaria. Proc. Symp. Environmental Pollutants, University of Connecticut, Storrs, Conn. In press.Google Scholar
- Chakraborty, J. and Smith, J. N. (1967) . Enzymic oxidation of some alkyl-benzenes in insects and vertebrates. Biochem. J., 102, 498–503.Google Scholar
- Gil, D. L., Rose, H. A., Yang, R. S. H., Young, R. G. and Wilkinson, C. F. (1974) . Enzyme induction by phenobarbital in the Madagascar cockroach, Gromphadorhina portentosa. Comp. Biochem. Physiol., 47B, 657–662.Google Scholar
- Schonbrod, R. D. and Terriere, L. C. (1971) . Eye pigments as inhibitors of microsomal aldrin epoxidase in the housefly. J. Econ. Entomol., 64, 44–45.Google Scholar
- Vandermeulen, J. H., Keizer, P. D. and Penrose, W. R. (1977) . Persistance of non-alkane components of bunker C oil in beach sediments of Chedabucto Bay, and their lack of metabolism by molluscs. Proc. 1977 Oil Spill Conference. American Petroleum Institute publication No. 4284, pp. 469–473.Google Scholar
- Yevich, P. P. and Barszcz, C. (1976). Gonadal and hematopoietic neoplasms in Mya arenaria. Mar. Fish. Rev., 38, 42–43.Google Scholar