Drug Receptors in the Lung Especially Histamine Receptors

  • Noemi Eiser
Part of the Ettore Majorana International Science Series book series (EMISS, volume 14)


Drugs produce their actions by combining with receptors. A specific response is produced when an agonist binds to a receptor. In contrast, when an antagonist combines with that receptor, it produces either no response or a decrease in the expected response of the agonist. Pre-treatment with the antagonist will shift the dose-response curve of the agonist to the right. This is known as competitive inhibition. Thus, while agonists have affinity and efficacy, antagonists have affinity only. In many cases the precise nature and location of the receptor is unknown but the properties of established agonists and antagonists have been utilized to investigate receptors both in vitro and in vivo. In this paper I shall concentrate on the findings of recent research into histamine receptors in the lung and then consider, briefly, the evidence concerning cholinergic, adrenergic and noncholinergic, nonadrenergic receptors.


Histamine Release Human Airway Histamine Receptor Asthmatic Subject Disodium Cromoglycate 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Noemi Eiser
    • 1
  1. 1.Department of Thoracic MedicineNew Cross HospitalLondonUK

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