Advertisement

ras Oncogenes pp 297-301 | Cite as

Structural Investigations on the G-Binding Domain of p21

  • Fred Wittinghofer
  • Jacob John
  • Emil Pai
  • Ilme Schlichting
  • Paul Rösch

Abstract

Ever since the ras gene product, p21, was discovered, it became clear, that it is a guanine nucleotide binding protein with significant homology to other G-binding proteins such as protein biosynthesis factors and signal-transducing G-proteins (Barbacid, 1987). Also, a lot of circumstantial evidence suggests that p21 is involved in a growth promoting signaltransduction pathway.

Keywords

Dissociation Rate Constant Guanine Nucleotide Binding Protein Ribose Ring 4ppm Downfield Aromatic Portion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barbacid, H. (1987), Ann.Rev.Biochem. 56, 779–827PubMedCrossRefGoogle Scholar
  2. de Vos, A., Tong, L., Milburn, M.V., Matias, P.M., Jancarik, J., Noguchi, S., Nishimura, S., Miura, K., Ohtsuka, E. and Kim, S.-H. (1988), Science 239, 888–893PubMedCrossRefGoogle Scholar
  3. John, J., Frech, M. and Wittinghofer, F. (1988), J.Biol.Chem. 263, 11792–11799PubMedGoogle Scholar
  4. Rösch, P. (1988), Biochem. Biophys. Res. Commun. 150, 444–448PubMedCrossRefGoogle Scholar
  5. Rösch, P. (1988), Biochem. Biophys. Res. Commun. 150, 444–448PubMedCrossRefGoogle Scholar
  6. Schlichting, I ., Wittinghofer, A. and Rösch, P. (1988) Biochem. Biophys. Res. Commun. 150, 444–448PubMedCrossRefGoogle Scholar
  7. Willumsen, B.M., Christensen, A., Hubbert, N.L. Papageorge, A.G. and Lowy, D.R. (1984), Nature (London) 310, 583–586CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Fred Wittinghofer
    • 1
  • Jacob John
    • 1
  • Emil Pai
    • 1
  • Ilme Schlichting
    • 1
  • Paul Rösch
    • 1
  1. 1.Max-Planck-Institut für medizinische ForschungAbteilung BiophysikHeidelbergGermany

Personalised recommendations