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ras Oncogenes pp 145-148 | Cite as

Phenotypic and Cytogenetic Alterations in Human Skin Keratinocytes after Transfection with the Cellular Harvey-ras (c-Ha-ras) Oncogene

  • P. Boukamp
  • R. T. Dzarlieva
  • Andrea Hülsen
  • E. J. Stanbridge
  • N. E. Fusenig

Abstract

Since activated ras oncogenes have been detected in a variety of human tumors, experiments were performed to determine the causal role of the oncogene in the development of neoplasia. So far transformation experiments with the ras oncogene using human epithelial cells was only described twice. The obvious difficulty to transform these cells, although beeing the major target cell of cancer in men, prompted us to study the oncogene action in human epidermal cells in more detail.

Keywords

HaCaT Cell Human Epithelial Cell Specific Integration Site Human Epidermal Cell Cytogenetic Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P. Boukamp
    • 1
  • R. T. Dzarlieva
    • 1
  • Andrea Hülsen
    • 1
  • E. J. Stanbridge
    • 2
  • N. E. Fusenig
    • 1
  1. 1.Institut fur BiochemieDKFZHeidelbergGermany
  2. 2.University of California IrvineIrvineUSA

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