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Rationale for Antiplatelet Agents in Diabetic Vascular Disease

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Book cover Thrombosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 102))

Abstract

Studies summarized in this paper indicate that some diabetics have increased sensitivity to platelet aggregating agents. The problem is in the platelet release reaction and may reflect increased synthesis of prostaglandins or their precursors. An interaction of plasma factors such as von Willebrand factor with platelets may also be involved. Based on these and other considerations, a prospective study on the use of aspirin and dipyridamole on diabetic lower extremity vascular disease is underway as a Veterans Administration Cooperative Study.

Supported by Veterans Administration Institutional Research Funds, South Carolina State Appropriation for Medical Research, and N.I.G. M.S. Grant No. 20387. Dr. Halushka is the recipient of a Pharmaceutical Manufacturer’s Association Foundation Development Award in Clinical Pharmacology. Dr. Sagel is Director, Specialized Diagnostic and Therapeutic Unit, Charleston Veterans Administration Hospital.

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Author information

Authors and Affiliations

  1. Charleston Veterans Administration Hospital; and the Endocrinology-Metabolism-Nutrition Division and the Clinical Pharmacology Division of the Department of Medicine, and Department of Pharmacology, Medical University of South Carolina, Charleston, SC, USA

    John A. Colwell M.D.,Ph.D., Perry V. Halushka M.D., Ph.D., Kay E. Sarji Ph.D. & Julius Sagel M.B.,Ch.B.

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  1. John A. Colwell M.D.,Ph.D.
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  2. Perry V. Halushka M.D., Ph.D.
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  3. Kay E. Sarji Ph.D.
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  4. Julius Sagel M.B.,Ch.B.
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Editor information

Editors and Affiliations

  1. Department of Medicine, Section of Hematology, Temple University, Health Sciences Center, 19140, Philadelphia, PA, USA

    H. James Day M.D.

  2. Diabetes and Atherosclerosis Research, The Upjohn Company, 49001, Kalamazoo, MI, USA

    Basil A. Molony M.D. , Edward E. Nishizawa Ph.D.  & Ronald H. Rynbrandt Ph.D. ,  & 

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© 1978 Springer Science+Business Media New York

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Colwell, J.A., Halushka, P.V., Sarji, K.E., Sagel, J. (1978). Rationale for Antiplatelet Agents in Diabetic Vascular Disease. In: Day, H.J., Molony, B.A., Nishizawa, E.E., Rynbrandt, R.H. (eds) Thrombosis. Advances in Experimental Medicine and Biology, vol 102. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1217-9_16

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  • DOI: https://doi.org/10.1007/978-1-4757-1217-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1219-3

  • Online ISBN: 978-1-4757-1217-9

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