Abstract
The meningococcal diseases* represent a spectrum of illness caused by Neisseria meningitidis.Although sporadic endemic cases occur throughout the world, massive, devastating epidemics tend to reflect conditions of crowding, mobilization, and enclosed institutional populations. Such outbreaks tend to be extraordinarily disruptive, especially because of the fear and fright that they induce in the affected populations. Among civilians , children are most often attacked, with mortality rates of 80–90% having been noted in some epidemics that occurred before effective therapeutic agents became available. The disease is also known as “cerebral spinal fever” and “epidemic cerebral spinal meningitis” and by other names. Mobilization for war, with the induction of many young men into crowded military camps, has generally been accompanied by outbreaks. This has been in contrast to the absence of such outbreaks among college freshmen, who also represent a mix from many diverse origins, in dormitories and other sometimes crowded living quarters on many campuses.
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References
Alexander, C. E., Sanborn, W. R., Cherriere, G., Crocker, W. H., Jr., Ewald, P. E., and Kay, C. R., Sulfadiazine-resistant Group A Neisseria meningitidis, Science 161:1019 (1968).
Apicella, M. A., Lipopolysaccharide-derived serotype polysaccharides from Neisseria meningitidisGroup B, J. Infect. Dis. 140:62–72 (1979).
Arkwright, J. A., Cerebro-spinal meningitis: The interpretation of epidemiological observations by the light of bacteriological knowledge, Br. Med. J. 1:494–496 (1915).
Artenstein, M. S., Control of meningococcal meningitis with meningococcal vaccines, Yale J. Biol. Med. 48:197–200 (1975).
Baltimore, R. S., and Hammerschlag, M., Meningococcal bacteremia: Clinical and serologic studies of infants with mild illness, Am. J. Dis. Child. 131:1001–1004 (1977).
Beeson, P. B., and Westerman, E., Cerebrospinal fever: Analysis of 3,575 case reports with special reference to sulphonamide therapy, Br. Med. J. 1:497–500 (1943).
Belcher, D. W., Sherriff, A. C., Nimo, K. P., Chew, G. L. N., Voros, A., Richardson, W. D., and Feldman, H. A., Meningococcal meningitis in northern Ghana: Epidemiology and control measures, Am. J. Trop. Med. Hyg. 26:748–755 (1977).
Benenson, A. S., Control of Communicable Diseases in Man,12th ed., p. 206, American Public Health Association, Washington, D.C., 1975 .
Blackwell, C., Young, H., and Bain, S. S. R., Isolation of Neisseria meningitidisand Neisseria catarrhalisfrom the genitourinary tract and anal canal, Br. J. Vener. Dis. 54:41–44 (1978).
Bolduan, C., and Goodwin, M. E., A clinical and bacteriological study of the communicability of cerebrospinal meningitis and the probable source of contagion: Part I of an investigation of cerebrospinal meningitis carried out under the auspices of the special commission of the Department of Health of New York City, Med. News 87: 1222–1228, (1905).
Bolduan, C., and Goodwin, M. E., A clinical and bacteriological study of the communicability of cerebrospinal meningitis and the probable source of contagion: Part I of an investigation of cerebrospinal meningitis carried out under the auspices of the special commission of the Department of Health of New York City, Med. News 87: 1250–1257 (1905).
Branham, S. E., Serological relationships among meningococci, Bacteriol. Rev. 17:175–188 (1953).
Carpenter, C. M., and Charles, R., Isolation of meningococcus from the genitourinary tract of seven patients, Am. J. Public Health 32:640–643 (1942).
Centers for Disease Control, Bacterial meningitis and meningococcemia—United States, 1978, Morbid. Mortal. Weekly Rep. 28:277–279 (1979).
Centers for Disease Control, Reported morbidity and mortality in the United States, annual summary 1979, Morbid. Mortal. Weekly Rep. 28:53–56 (1980).
Centers for Disease Control, Recommendation of the Immunization Practices Advisory Committee (Acip): Meningococcal vaccines, Morbid. Mortal. Weekly Rep. 34:255–259 (1985).
Centers for Disease Control, Annual summary 1984: Reported morbidity and mortality in the United States, Morbid. Mortal. Weekly Rep. 33:38 (1986).
Centers for Disease Control, Summary of Notifiable Diseases, United States, Morbid. Mortal. Weekly Rep. 35:30 (1986).
Cheever, F. S., The control of meningococcal meningitis by mass chemoprophylaxis with sulfadiazine, Am. J. Med. Sci. 209:74–75 (1945).
Cheever, F. S., Breese, B. B., and Upham, H. C., The treatment of meningococcus carriers with sulfadiazine, Ann. Intern. Med. 19:602–608 (1943).
Cohen, M. S., Steere, A. C., Baltimore, R. S., Von Graevenitz, A., Pantelick, E., Camp, B., and Root, R. A., Possible nosocomial transmission of Group Y Neisseria meningitidisamong oncology patients, Ann. Intern. Med. 91:7–12 (1979).
Cohen, R. L., and Artenstein, M. S., Hemagglutination inhibition for serogrouping Neisseria meningitidis, Appl. Microbiol. 23:289–292 (1972).
Corfield, W. F., Multiple attacks of cerebrospinal fever, Lancet 1:402–403 (1945).
Daniels, W. B., Solomon, S., and Jaquette, W. A. Jr., Meningococcic infections in soldiers, J. Am. Med. Assoc. 123:1–9 (1943).
Danielson, L., and Mann, E., The history of a singular and very mortal disease, which lately made its appearance in Medfield, Med. Agric. Register 1:65–69 (1806).
Devine, L. F., Johnson, D. P., Hagerman, C. R., Pierce, W. E., Rhode, S. L., III, and Peckinpaugh, R. O., The effect of minocycline on meningococcal nasopharyngeal car-rier state in naval personnel, Am. J. Epidemiol. 93:337–345 (1971).
Dingle, J. H., and Finland, M., Diagnosis, treatment and prevention of meningococcic meningitis, with a resume of the practical aspects of treatment of other acute bacterial meningitides, War Med. 2:1–58 (1942).
Dingle, J. H., Thomas, L., and Morton, A. R., Treatment of meningococcic meningitis and meningococcemia with sulfadiazine, J. Am. Med. Assoc. 116:2666–2668 (1941).
Drew, T. M., Altman, R., Black, K., and Goldfield, M., Minocycline for prophylaxis of infection with Neisseria meningitidis: High rate of side effects in recipients, J. Infect. Dis. 133:194–198 (1976).
Dudley, S. F., and Brennan, J. R., High and persistent carrier rates of Neisseria meningitidis,unaccompanied by cases of meningitis, J. Hyg. 34:525–541 (1934).
Ellison, R. T., III, Kohler, P. F., Curd, J. G., Judson, F. N., and Reller, L. B., Prevalence of congenital or acquired complement deficiency in patients with sporadic meningococcal disease, N. Engl. J. Med. 308:914–916 (1983).
Eschenbach, D. A., Buchanan, T. M., Pollock, H. M., Forsyth, P. S., Alexander, E. R., Lin, J.-S., Wang, S.P., Wentworth, B. B., Mccormack, W. M., and Holmes, K. K., Polymicrobial etiology of acute pelvic inflammatory disease, N. Engl. J. Med. 293:166–171 (1975).
Evans, J. R., Artenstein, M. S., and Hunter, D. H., Prevalence of meningococcal serogroups and description of three new groups, Am. J. Epidemiol. 87:643–646 (1968).
Fallon, R. J., and Robinson, E. T., Meningococcal vulvovaginitis, Scand. J. Infect. Dis. 6:295–296 (1974).
Faur, Y. C., Weisburd, M. H., and Wilson, M. E., Isolation of Neisseria meningitidisfrom the genito-urinary tract and canal, J. Clin. Microbiol. 2:178–182 (1975).
Feldman, H. A., Sulfonamide-resistant meningococci, Annu. Rev. Med. 18:495–506 (1967).
Feldman, H. A., Neisseria infections other than gonococcal, in:Diagnostic Procedures for Bacterial, Mycotic and Parasitic Infections(H. L. Bodily, E. L. Updyke, and J. O. Mason, eds.), pp. 135–152, American Public Health Association, New York, 1970.
Feldman, H. A., Meningococcal infections, Adv. Intern. Med. 18:117–140 (1972).
Feldman, H. A., Editorial comment,in: Year Book of Pediatrics(S. S. Gellis, ed.), p. 81, Year Book Medical, Chicago, 1975.
Feldman, H. A., Sweet, L. K., and Dowling, H. F., Sulfadiazine therapy of purulent meningitis including its use in 24 consecutive patients with meningococcic meningitis, War Med. 2:995–1007 (1942).
Feldman, R. A., Koehler, R. E., and Fraser, D. W., Race-specific differences in bacterial meningitis deaths in the United States, 1962–1968, Am. J. Public Health 66:392–396 (1976).
Frasch, C. E., and Chapman, S. S., Classification of Neisseria meningitidisGroup B into distinct serotypes. III. Application of a new bactericidal-inhibition technique to distribution of serotypes among cases and carriers, J. Infect. Dis. 127:149–154 (1973).
Fraser, D. W., Darby, C. P., Koehler, R. E., Jacobs, C. F., and Feldman, R. A., Risk factors in bacterial meningitis: Charleston County, South Carolina, J. Infect. Dis. 127:271–277 (1973).
Gauld, J. R., Nitz, R. E., Hunter, D. H., Rust, J. H., and Gauld, R. L., Epidemiology of meningococcal meningitis at Fort Ord, Am. J. Epidemiol. 82:56–72 (1965).
Givan, K. F., Thomas, B. W., and Johnston, A. G., Isolation of Neisseria meningitidisfrom the urethra, cervix, and anal canal: Further observations, Br. J. Vener. Dis. 53:109–112 (1977).
Glover, J. A., Observations of the meningococcus carrier rate, and their application to the prevention of cerebrospinal fever, Medical Research Council of the Privy Council, Special Report Series, No. 50, pp. 133–165, H. M. Stationery Offices, London (1920).
Gold, R., Polysaccharide meningococcal vaccines-Current status, Hosp. Pract. 14:41–48 (1979).
Gold, R., Lepow, M. L., Goldschneider, I., Draper, T. L., and Gotschlich, E. C., Clinical evaluation of Group A and Group C meningococcal polysaccharide vaccines in infants, J. Clin. Invest. 56:1536–1547 (1975).
Goldschneider, I., Gotschlich, E. C., and Artenstein, M. S ., Human immunity to the meningococcus. I. The role of humoral antibodies, J. Exp. Med. 129:1307–1326 (1969).
Gordon, M. H., Identification of the meningococcus, J. R. Army Med. Corps 24:455–458 (1915).
Gotschlich, E. C., Goldschneider, I., and Artenstein, M. S., Human immunity to the meningococcus. V. The effect of immunization with meningococcal Group C polysaccharide on the carrier stateJ. Exp. Med. 129:1385–1395 (1969).
Gotschlich, E. C., Liu, T. Y., and Artenstein, M. S., Human immunity to the meningococcus. III. Preparation and immunochemical properties of the Group A, Group B, and Group C meningococcal polysaccharides, J. Exp. Med. 129:1349–1365 (1969).
Gray, F. C., and Gear, J., Sulphapyridine, M and B 693, as a prophylactic against cerebrospinal meningitis, S. Afr. Med. J. 15:139–140 (1941).
Greenfield, S., Sheehe, P. R., and Feldman, H. A., Meningococcal carriage in a population of “normal” families, J. Infect. Dis. 123:67–73 (1971).
Greenwood, B. M., Hassan-King, M., and Whittle, H. C., Prevention of secondary cases of meningococcal disease in household contacts by vaccination, Br. Med. J. 1:1317–1319 (1978).
Greenwood, B. M., Bradley, A. K., Cleland, P. G., Haggie, M. H. K., Hassan-King, M., Lewis, L. S., Macfarlane, J. T., Taqi, A., and Whittle, H. C., An epidemic of meningococcal infection at Zaria, northern Nigeria. 1. General epidemiological features, Trans. R. Soc. Trop. Med. Hyg. 73:557–562 (1979).
Greenwood, B. M., Cleland, P. G., Haggie, M. H. K., Lewis, L. S., Macfarlane, J. T., Taqi, A., and Whittle, H. C., An epidemic of meningococcal infection at Zaria, northern Nigeria. 2. The changing clinical pattern, Trans. R. Soc. Trop. Med. Hyg. 73:563–566 (1979).
Gregory, J. E., and Abramson, E., Meningococci in vaginitis, Am. J. Dis. Child. 121:423 (1971).
Griffiss, J. M., Epidemic meningococcal disease: Synthesis of a hypothetical immunoepidemiologic model, Rev. Infect. Dis. 4:159–172 (1982).
Griffiss, J. M., and Brandt, M. S., Disease due to W135 Neisseria meningitidis, Pediatrics 64:218–221 (1979).
Gruss, A.D., Spier-Michl, I. B., and Gotschlich, E. C., A method for a radioimmunoassay using microtiter plates allowing simultaneous determination of antibodies to two non crossreactive antigens, Immunochemistry 15:777–780 (1978).
Hammerschlag, M. R., and Baker, C. J., Meningococcal osteomyelitis: A report of two cases associated with septic arthritis, J. Pediatr. 88:519–520 (1976).
Hammerschlag, M. R., and Baltimore, R. S., Infections in children due to Neisseria meningitidisserogroup 135, J. Pediatr. 92:503–504 (1978).
Hassan-King, M., Greenwood, B. M., and Whittle, H. C., An epidemic of meningococcal infection at Zaria, northern Nigeria. 3. Meningococcal carriage, Trans. R. Soc. Trop. Med. Hyg. 73:567–573 (1979).
Hersh, J. H., Gold, R., and Lepow, M. L., Meningococcal Group Y pneumonia in an adolescent female, Pediatrics 64:222–224 (1979).
Horn, D. W., The epidemic of cerebrospinal fever in the northern provinces of Nigeria, 1949–1950, J. R. Sanit. Inst. 71:573–588 (1951).
Jacobson, J. A., Weaver, R. E., and Thornsberry, C., Trends in meningococcal disease, 1974, J. Infect. Dis. 132:480–484 (1975).
Jacobson, J. A., Camargos, P. A. M., Ferreira, J. T., and Mccormick, J. B., The risk of meningitis among classroom contacts during an epidemic of meningococcal disease, Am. J. Epidemiol. 104:552–555 (1976).
Klein, J. O., Feigin, R. D., and Mccracken, G. H., Jr., Report of the task force on diagnosis and management of meningitis, Pediatrics 78(S):959–982 (1986).
Koppes, G. M., Ellenbogen, C., and Gebhart, R. J., Group Y meningococcal disease in United States Air Force recruits, Am. J. Med. 62:661–714 (1977).
Kuhns, D. M., Nelson, C. T., Feldman, H. A., and Kuhn, L. R., The prophylactic value of sulfadiazine in the control of meningococcic meningitis, J. Am. Med. Assoc. 123:335–339 (1943).
Laggiado, R. J., and Winkelstein, J. A., Prevalence of complement deficiencies in children with systemic meningococcal infections, Pediatr. Infect. Dis. 6:75–76 (1987).
Laird, S. M., Meningococcal epididymitis, Lancet 1:469–470 (1944).
Lapeyssonnie, L., La méningite cérébro-spinale en Afrique, Bull. Who 28(Suppl.) (1963).
Leedom, J. M., Ivler, D., Mathies, A. W., Jr., Thrupp, L. D., Fremont, J. C., Wehrle, P. F., and Portnoy, B., The problem of sulfadiazine-resistant meningococci, in: Antimicrobial Agents and Chemotherapy, 1966,pp. 281–292 (1967).
Lepow, M. L., Beeler, J., Randolph, M., Samuelson, J. S., and Hankins, W. A., Reactogenicity and immunogenicity of a quadrivalent combined meningococcal polysaccharide vaccine in children, J. Infect. Dis. 154:1033–1036 (1986).
Mäkelä, P. H., Peltola, H., Käyhty, H., Jousimies, H., Pettay, O., Ruoslahti, E., Sivonen, A., and Renkonen, O.-V., Polysaccharide vaccines of group A Neisseria meningitidisand Haemophilus influenzaetype b: A field trial in Finland, J. Infect. Dis. 136:S43-S50 (1977).
Maxcy, K. F., The relationship of meningococcus carriers to the incidence of cerebrospinal fever, Am. J. Med. Sci. 193:438–445 (1937).
Mayer, R. L., and Dowling, H. F., The determination of meningococcic antibodies by a centrifuge-agglutination test, J. Immunol. 51:349–354 (1945).
Meningococcal Disease Surveillance Group, Meningococcal disease: Secondary attack rate and chemoprophylaxis in the United States, 1974, J. Am. Med. Assoc. 235:261–265 (1976).
Millar, J. W., Siess, E. E., Feldman, H. A., Silverman, C., and Frank, P., In vivoand in vitroresistance to sulfadiazine in strains of Neisseria meningitidis, J. Am. Med. Assoc. 186:139–141 (1963).
Miller, M. A., Millikin, P., Griffin, P. S., Sexton, R. A., and Yousuf, M., Neisseria meningitidisurethritis: A case report, J. Am. Med. Assoc. 242:1656–1657 (1979).
Munford, R. S., Sussuarana De Vasconcelos, Z. J., Phillips, C. J., Gelli, D. S., Gorman, G. W., Risi, J. B., and Feldman, R. A., Eradication of carriage of Neisseria meningitidis infamilies: A study in Brazil, J. Infect. Dis. 129:644–659 (1974).
Murray, E. G. D., Meningococcus infections of the male urogenital tract and the liability to confusion with gonococcus infection, Urol. Cutaneous Rev. 43:739–741 (1939).
Norton, J. F., Meningococcus meningitis in Detroit: 1928–1929. V. Secondary cases, J. Prey. Med. 5:365–367 (1931).
Norton, J. F., and Gordon, J. E., Meningococcus meningitis in Detroit in 1928–1929. I. Epidemiology, J. Prey. Med. 4:207–214 (1930).
Olcén, P., Barr, J., and Kjellander, J., Meningitis and bacteremia due to Neisseria meningitidis: Clinical and laboratory findings in 69 cases from Orebro County, 1965 to 1977, Scand. J. Infect. Dis. 11:111–119 (1979).
Pan American Health Organization, Report of the first hemispheric meeting on meningococcal disease, Pan. Am. Health Organ. Bull. 10:163–174 (1976).
Paul, J. R., Clinical Epidemiology,p. 192, University of Chicago Press, Chicago, 1966.
Peltola, H., Mäkelä, H., Käyhty, H., Jousimies, H., Herva, E., Hällström, K., Sivonen, H., Renkonen, O.V., Péttay, O., Karanko, V., Ahvonen, P., and Sarna, S., Clinical efficacy of meningococcal Group A polysaccharide vaccine in children three months to five years of age, N. Engl. J. Med. 297:686–691 (1977).
Petersen, B. H., Lee, T. J., Snyderman, R., and Brooks, G. F., Neisseria meningitidisand Neisseria gonorrhoeaebacteremia associated with C6, C7, or C8 deficiency, Ann. Intern. Med. 90:917–920 (1979).
Phair, J. J., Schoenbach, E. B., and Root, C. M., Meningococcal carrier studies, Am.J. Public Health 34:148–154 (1944).
Pike, R. M., Laboratory-associated infections: Incidence, fatalities, causes, and prevention, Annu. Rev. Microbiol. 33:41–66 (1979).
Pizzi, M., A severe epidemic of meningococcus meningitis in Chile, 1941–1942, Am.J. Public Health 34:231–238 (1944).
Rake, G., Studies on meningococcus infection. Vi. The carrier problem, J. Exp. Med. 59:553–576 (1934).
Reiss-Levy, E., and Stephenson, J., Vaginal isolation of Neisseria meningitidisin association with meningococcaemiaAust. N. Z. J. Med. 6:487–489 (1976).
Schoenbach, E. B., The meningococcal carrier state,Med. Ann. D. C. 12:417–420 (1943).
Sivonen, A., Renkonen, O.-V., Weckstrom, P., Koskenvuo, K., Raunio, V., and Mäkelä, P. H., The effect of chemoprophylactic use of rifampin and minocycline on rates of carriage of Neisseria meningitidisin Army recruits in Finland, J. Infect. Dis. 137:238–244 (1978).
Slaterus, K. W., Serological typing of meningococci by means of microprecipitation, Antonie van Leeuwenhoek J. Microbiol. Serol. 27:304–315 (1961).
Stephens, D. S., Edwards, K. M., and Mckee, K. T., Meningococcal Group Y disease in children, Pediatr. Infect. Dis. 3:523–525 (1984).
Thayer, J. D., and Martin, J. E. Jr., A selective medium for the cultivation of N. gonorrhoeaeand N. meningitidis, Public Health Rep. 79:49–57 (1964).
The Medical Letter Inc., Preventing the spread of meningococcal disease, The Medical Letter 23:37–38 (1981).
Thomas, L., Smith, H. W., and Dingle, J. H., Investigation of meningococcal infection. II. Immunological aspects, J. Clin. Invest. 22:361–373 (1943).
Vieusseux, M., Mémoire sur le maladie qui a regné à Génève au printemps de 1805, J. Med. Chir. Pharmacol. 11:163 (1805).
Wahdan, M. H., Rizk, F., El-Akkad, A. M., El Ghoroury, A. E., Hablas, R., Girgis, N. I., Amer, A., Boctar, W., Sippel, J. E., Gotschlich, E. C., Triau, R., Sanborn, W. R., and Cvjetanovic, B., A controlled field trial of a serogroup A meningococcal polysaccharide vaccine, Bull. WHO 48:667–673 (1973).
Weichselbaum, A., Ueber die Aetiologie der akuten Meningitis cerebrospinalis, Fortschr. Med. 5:573 (1887).
Zollinger, W. D., and Mandrell, R. E., Outer-membrane protein and lipopolysaccharide serotyping of Neisseria meningitidisby inhibition of a solid-phase radioimmunoassay, Infect. Immun. 18:424–433 (1977).
Suggested Reading
Arkwright, J. A., Cerebro-spinal meningitis: The interpretation of epidemiological observations by the light of bacteriological knowledge, Br. Med. J. 1:494–496 (1915).
Dingle, J. H., and Finland, M., Diagnosis, treatment and prevention of meningococcic meningitis, with a resume of the practical aspects of treatment of other acute bacterial meningitides, War Med. 2:1–58 (1942).
Feldman, H. A., Recent developments in the therapy and control of meningococcal infections, Dis. Month(Feb. 1966).
Feldman, H. A., Sulfonamide-resistant meningococci, Annu. Rev. Med. 18:495–506 (1967).
Feldman, H. A., Meningococcal infections, in: Adv. Intern. Med. 18:117–140 (1972).
Gotschlich, E. C., Liu, T. Y., and Artenstein, M. S., Human immunity to the meningococcus. III. Preparation and immunochemical properties of the Group A, Group B, and Group C meningococcal polysaccharides, J. Exp. Med. 129:1349–1365 (1969).
Greenfield, S., Sheehe, P. R., and Feldman, H. A., Meningococcal carriage in a population of “normal” families,J. Infect. Dis. 123: 67–73 (1971).
Sivonen, A., Renkonen, O.-V., Weckstrom, P., Koskenvuo, K., Raunio, V., and Mäkelä, P. H., The effect of chemoprophylactic use of rifampin and minocycline on rates of carriage of Neisseria meningitidisin Army recruits in Finland, J. Infect. Dis. 137:238–244 (1978).
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Baltimore, R.S., Feldman, H.A. (1991). Meningococcal Infections. In: Evans, A.S., Brachman, P.S. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1211-7_20
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