Vascular Muscle Membrane Properties in Hypertension

  • Kent Hermsmeyer
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)


Although it would be ideal to present a discussion of how the coronary circulation is altered at the cell level in hypertension, there exist virtually no data comparing membrane properties of coronary vascular muscle cells from hypertensive and normotensive animals. However, the elevated peripheral resistance in hypertension is believed to be a predisposing influence to cardiac pathology. In this light, the present chapter is included to identify the changes in vascular muscle that result in increased peripheral resistance and so increase the workload of the heart. It might be hoped that the properties of the coronary circulation will be sufficiently different from the peripheral vasculature that new antihypertensive agents (e.g., perhaps selective Ca2+ antagonists such as nitrendipine) might cause relaxation of specifically the peripheral vasculature without diminishing the regulatory mechanisms operating in the coronary circulation. In any event, the specific comparative study of the coronary vascular muscle cells of normotensive and hypertensive animals is needed.


Coronary Circulation Arterial Muscle Peripheral Vasculature Caudal Artery Vascular Muscle 
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© Springer Science+Business Media Dordrecht 1984

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  • Kent Hermsmeyer

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