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Methods for Detecting Calcium Release from the Sarcoplasmic Reticulum of Skinned Cardiac Cells and the Relationships Between Calculated Transsarcolemmal Calcium Movements and Calcium Release

  • Alexandre Fabiato
  • Clive Marc Baumgarten
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)

Abstract

The mechanism of excitation-contraction coupling is not established for any type of muscle [1–3]. In cardiac muscle there is not even universal agreement on whether Ca2+ is released from the sarcoplasmic reticulum (SR) during excitation-contraction coupling. This will be the first question addressed in this chapter. In the discussion of this question, emphasis will be placed on the quantification of the Ca2+ fluxes across the sarcolemma and their possible relationships with the Ca2+ movements in and out of the SR. A detailed description of the simple calculations that permit this correlation will provide a tool for a critical analysis of the literature.

Keywords

Sarcoplasmic Reticulum Cardiac Muscle Cardiac Cell Coupling Ratio Sarcoplasmic Reticulum Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media Dordrecht 1984

Authors and Affiliations

  • Alexandre Fabiato
  • Clive Marc Baumgarten

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