Escherichia coli Diarrhea

  • Herbert L. DuPont


During the 1940s and 1950s, a series of outbreaks of diarrhea in hospital newborn nurseries were reported in which the etiological agent appeared to be Escherichia coli identified by serotype. These strains became known as enteropathogenic E. coli (Epec). Little information has been gathered about these strains in recent years, although it is generally recognized that they are responsible for diarrhea among children under 2 years of age.


Escherichia Coli Bacillary Dysentery Infantile Diarrhea EPEC Strain ETEC Strain 
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  1. 1.
    Arbuckle, J. B. R., The location of Escherichia coli in the pig intestine, J. Med. Microbiol. 3:333–340 (1970).PubMedCrossRefGoogle Scholar
  2. 2.
    Avery, G. B., Villavicencio, O., Lilly, J. R., and Randolph, J. G., Intractable diarrhea in early infancy, Pediatrics 41:712–722 (1968).Google Scholar
  3. 3.
    Baker, C. J., Barrett, F. F., and Clark, D. J., Antibiotic susceptibility patterns of enteropathogenic Escherichia coli isolates, South. Med. J. 67:412–414 (1974).PubMedCrossRefGoogle Scholar
  4. 4.
    Belnap, W. D., and O’donnell, J. J., Epidemic gastroenteritis due to Escherichia coli 0–111: A review of the literature, with the epidemiology, bacteriology, and clinical findings of a large outbreak, J. Pediatr. 47:178–193 (1955).PubMedCrossRefGoogle Scholar
  5. 5.
    Boris, M., Thomason, B. M., Hines, V. D., Montague, T. S., and Sellers, T. F. Jr., A community epidemic of enteropathogenic Escherichia coli 0126 : B16 : Nm gastroenteritis associated with asymptomatic respiratory infection, Pediatrics 33:18–29 (1964).PubMedGoogle Scholar
  6. 6.
    Bray, J., Isolation of antigenically homogeneous strains of Bact. coli neapolitanum from summer diarrhoea of infants, J. Pathol. Bacteriol. 57:239–247 (1945).CrossRefGoogle Scholar
  7. 7.
    Byers, P. A., and Dupont, H. L., Pooling method for screening large numbers of Escherichia coli for production of heat-stable enterotoxin, and its application in field studies, J. Clin. Microbiol. 9:541–543 (1979).PubMedGoogle Scholar
  8. 8.
    Cooper, M. L., Keller, H. M., Walters, E. W., Partin, J. C., and Boye, D. E., Isolation of enteropathogenic Escherichia coli from mothers and newborn infants, Am. J. Dis. Child. 97:255–266 (1959).Google Scholar
  9. 9.
    De, S. N., and Chatterje, D. N., An experimental study of action of Vibrio cholerae on the intestinal mucous membrane, J. Pathol. Bacteriol. 66:559–562 (1953).PubMedCrossRefGoogle Scholar
  10. 10.
    Dean, A. G., Ching, Y., Nilliams, R. G., and Harden, L. B., Test for Escherichia coli enterotoxin using infant mice: Application in a study of diarrhea in children in Honolulu, J. Infect. Dis. 125:407–411 (1972).PubMedCrossRefGoogle Scholar
  11. 11.
    Donta, S. T., Moon, H. W., and Whipp, S. C., Detection of heat-labile Escherichia coli enterotoxin with the use of adrenal cells in tissue culture, Science 183:334–336 (1974).PubMedCrossRefGoogle Scholar
  12. 12.
    Donta, S. T., Sack, D. A., Wallace, R. B., Dupont, H. L., and Sack, R. B., Tissue-culture assay of antibodies to heat-labile Escherichia coli enterotoxins, N. Engl. J. Med. 291:117–121 (1974).PubMedCrossRefGoogle Scholar
  13. 13.
    Dupont, H. L., Formal, S. B., Hornick, R. B., Snyder, M. J., Libonati, J. P., Sheahan, D. G., Labrec, E. H., and Kalas, J. P., Pathogenesis of Escherichia coli diarrhea, N. Engl. J. Med. 285:1–9 (1971).PubMedCrossRefGoogle Scholar
  14. 14.
    Dupont, H. L., Hornick, R. B., Dawkins, A. T., Snyder, M. J., and Formal, S. B., The response of man to virulent Shigella flexneri 2a, J. Infect. Dis. 119:296–299 (1969).PubMedCrossRefGoogle Scholar
  15. 15.
    Dupont, H. L., Olarte, J., Evans, D. G., Pickering, L. K., Galindo, E., and Evans, D. J., Jr., Comparative susceptibility of Latin American and United States students to enteric pathogens, N. Engl. J. Med. 295:1520–1521 (1976).PubMedCrossRefGoogle Scholar
  16. 16.
    Dupont, H. L., Sullivan, P., Evans, D. G., Pickering, L. K., Evans, D. J. Jr., Vollet, J. J ., Ericsson, C. D., Ackerman, P. B., and Tjoa, W. S. Prevention of travelers’ diarrhea (emporiatric enteritis) by prophylactic administration of bismuth subsalicylate, J. Am. Med. Assoc. 243:237–241 (1980).CrossRefGoogle Scholar
  17. 17.
    Drucker, M. M., Poliack, A., Yeivin, R., and Sacks, T. G., Immunofluorescent demonstration of enteropathogenic Escherichia coli in tissues of infants dying with enteritis, Pediatrics 46:855–864 (1970).PubMedGoogle Scholar
  18. 18.
    Echeverria, P., Blacklow, N. R., and Smith, D. H., Role of heat-labile toxigenic Escherichia coli and reovirus-like agent in diarrhoea in Boston children, Lancet 2:1113–1116 (1975).PubMedCrossRefGoogle Scholar
  19. 19.
    Edwards, P. R., and Ewing, W. H., The genus Escherichia, in: Identification of Enterobacteriaceae, 3rd ed., Burgess Publishing, Minneapolis, 1972.Google Scholar
  20. 20.
    Evans, D. G., Evans, D. J., Jr., and Dupont, H. L., Virulence factors of enterotoxigenic Escherichia coli, J. Infect. Dis. 136:S118-S123 (1977).Google Scholar
  21. 21.
    Evans, D. G., Evans, D. J., Jr., and Pierce, N. F., Differences in the response of rabbit small intestine to heat-labile and heat-stable enterotoxins of Escherichia coli, Infect. Immun. 7:873–880 (1973).Google Scholar
  22. 22.
    Evans, D. J. Jr., and Evans, D. G., Direct serological assay for the heat-labile enterotoxin of Escherichia coli using passive immune hemolysis, Infect. Immun. 16:604–609 (1977).PubMedGoogle Scholar
  23. 23.
    Evans, D. J., Jr., Evans, D. G., Dupont, H. L., ØRskov, F., and ØRskov, I., Patterns of loss of enterotoxigenicity by Escherichia coli isolated from adults with diarrhea: Suggestive evidence for an interrelationship with serotype, Infect. Immun. 17:105–111 (1977).PubMedGoogle Scholar
  24. 24.
    Evans, D. J. Jr., Evans, D. G., and Gorbach, S. L., Production of vascular permeability factor by enterotoxigenic Escherichia coli isolated from man, Infect. Immun. 8:725–730 (1973).PubMedGoogle Scholar
  25. 25.
    Evans, D. J., Jr., Ruiz-Palacios, G., Evans, D. G., Dupont, H. L., Pickering, L. K., and Olarte, J., Humoral immune response to the heat-labile enterotoxin of Escherichia coli in naturally acquired diarrhea and antitoxin determination by passive immune hemolysis, Infect. Immun. 16:781–788 (1977).PubMedGoogle Scholar
  26. 26.
    Farmer, J. J. III., Davis, B. R., Cherry, W. B., Brenner, D. J., Dowell, V. R. Jr., and Balows, A., “Enteropathogenic serotypes” of Escherichia coli which really are not, J. Pediatr. 90:1047–1049 (1977).PubMedCrossRefGoogle Scholar
  27. 27.
    Ferguson, W. W., and June, R. C., Experiments on feeding adult volunteers with Escherichia coli 111,B4, a coliform organism associated with infant diarrhea, Am. J. Hyg. 55:155–169 (1952).PubMedGoogle Scholar
  28. 28.
    Field, M., Graf, L. H., Jr., Laird, W. J., and Smith, P. L., Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate cyclase activity, cyclic Gmp concentration, and ion transport in small intestine, Proc. Natl. Acad. Sci. U.S.A. 75:2800–2804 (1978).PubMedCrossRefGoogle Scholar
  29. 29.
    Giannella, R. A., Suckling mouse model for detection of heat-stable Escherichia coli enterotoxin: Characteristics of the model, Infect. Immun. 14:95–99 (1976).PubMedGoogle Scholar
  30. 30.
    Giles, C., Sangster, G., and Smith, J., Epidemic gastro-enteritis of infants in Aberdeen during 1947, Arch. Dis. Child. 24:45–53 (1949).PubMedCrossRefGoogle Scholar
  31. 31.
    Goldschmidt, M., and Dupont, H. L., Enteropathogenic Escherichia coli: Lack of correlation of serotype with pathogenicity, J. Infect. Dis. 133:153–156 (1976).PubMedCrossRefGoogle Scholar
  32. 32.
    Gorbach, S. L., Banwell, J. G., Chatterjee, B. D., Jacobs, B., and Sack, R. B., Acute undifferentiated human diarrhea in the tropics. I. Alterations in intestinal microflora, J. Clin. Invest. 50:881–889 (1971).PubMedCrossRefGoogle Scholar
  33. 33.
    Gorbach, S. L., Kean, B. H., Evans, D. G., Evans, D. J. Jr., and Bessudo, D., Traveler’s diarrhea and toxigenic Escherichia coli, N. Engl. J. Med. 292:933–936 (1975).PubMedCrossRefGoogle Scholar
  34. 34.
    Gorbach, S. L., and Khurana, C. M., Toxigenic Escherichia coli: A cause of infantile diarrhea in Chicago, N. Engl. J. Med. 287:791–795 (1972).PubMedCrossRefGoogle Scholar
  35. 35.
    Guerrant, R. L., and Brunton, L. L., Characterization of the Chinese hamster ovary cell assay for the enterotoxins of Vibrio cholerae and Escherichia coli and for antitoxin: Differential inhibition by gangliosides, specific antisera, and toxoid, J. Infect. Dis. 135:720–728 (1977).PubMedCrossRefGoogle Scholar
  36. 36.
    Guerrant, R. L., Dickens, M. D., Wenzel, R. P., and Kapikian, A. Z., Toxigenic bacterial diarrhea: Outbreak involving multiple bacterial strains, J. Pediatr. 89:885–891 (1976).PubMedCrossRefGoogle Scholar
  37. 37.
    Guerrant, R. L., Moore, R. A., Kirschenfeld, P. M. and Sande, M. A., Role of toxigenic and invasive bacteria in acute diarrhea of childhood, N. Engl. J. Med. 293:567–573 (1975).PubMedCrossRefGoogle Scholar
  38. 38.
    Gurwith, M., Hinde, D., Gross, R., and Rowe, B., A prospective study of enteropathogenic Escherichia coli in endemic diarrheal disease, J. Infect. Dis. 137:292–297 (1978).PubMedCrossRefGoogle Scholar
  39. 39.
    Gurwith, M. J . , and Williams, T. W., Gastroenteritis in children: A two-year review in Manitoba. I. Etiology, J. Infect. Dis. 136:239–247 (1977).PubMedCrossRefGoogle Scholar
  40. 40.
    Gurwith, M. J., Wiseman, D. A., and Chow, P., Clinical and laboratory assessment of the pathogenicity of serotyped enterotoxigenic Escherichia coli, J. Infect. Dis. 135:736–743 (1977).Google Scholar
  41. 41.
    Gyles, C., So, M., and Falkow, S., The enterotoxin plasmids of Escherichia coli, J. Infect. Dis. 130:40–49 (1974).Google Scholar
  42. 42.
    Hughes, J. M., Murad, F., Chang, B., and Guerrant, R. L., Role of cyclic Gmp in the action of heat-stable enterotoxin of Escherichia coli, Nature (London) 271:755–756 (1978).CrossRefGoogle Scholar
  43. 43.
    Ironside, A. G., Tuxford, A. F., and Heyworth, B., A survey of infantile gastroenteritis, Br. Med. J. 3:20–24 (1970).PubMedCrossRefGoogle Scholar
  44. 44.
    Saacson, R. E., Fusco, P. C., Brinton, C. C. and Moon, H. W., In vitro adhesion of Escherichia coli to porcine small intestinal epithelial cells: Pili as adhesive factors, Infect. Immun. 21:392–397 (1978).Google Scholar
  45. 45.
    June, R. C., Ferguson, W. W., and Worfel, M. T., Experiments in feeding adult volunteers with Escherichia coli 55,B5 a coliform organism associated with infant diarrhea, Am. J. Hyg. 57:222–236 (1953).PubMedGoogle Scholar
  46. 46.
    Jones, G. W., and Rutter, J. M., Role of the K88 antigen in the pathogenesis of neonatal diarrhea caused by E scherichia coli in piglets, I nfect. Immun. 6:918–927 (1972).Google Scholar
  47. 47.
    Kapikian, A. Z., Kim, H. W., and Wyatt, R. G., Human reovirus-like agent as the major pathogen associated with “winter” gastroenteritis in hospitalized infants and young children, N. Engl. J. Med. 294:965–972 (1976).PubMedCrossRefGoogle Scholar
  48. 48.
    Kaslow, R. A., Taylor, A., Jr., Dweck, H. S., Bobo, R. A., Steele, C. D., and Cassady, G., Jr., Enteropathogenic Escherichia coli infection in a newborn nursery, Am. J. Dis. Child. 128:797–801 (1974).PubMedGoogle Scholar
  49. 49.
    Kauffmann, F., The serology of the coli group, J. Immunol. 57:71–100 (1947).PubMedGoogle Scholar
  50. 50.
    Kauffman, F., and Dupont, A. J., Escherichia strains from infantile epidemic gastroenteritis, Acta Pathol. Microbiol. Scand. 27:552–564 (1950).CrossRefGoogle Scholar
  51. 51.
    Kessner, D. M., Shaughnessy, H. J., Googins,J., Rasmussen, C. M., Rose, M. J., Marshall, A. L., Jr., and Elman, S. L., Hall, J. B., and Rosenbloom, P. J., An extensive community outbreak of diarrhea due to enteropathogenic Escherichia coli 011:B4. I. Epidemiologic studies, Am. J. Hyg. 76:27–43 (1962).PubMedGoogle Scholar
  52. 52.
    Klipstein, F. A., Rowe, B., Engert, R. F., Short, H. B., and Gross, R. J., Enterotoxigenicity of enteropathogenic serotypes of Escherichia coli isolated from infants with epidemic diarrhea, Infect. Immun. 21:171–178 (1978).PubMedGoogle Scholar
  53. 53.
    Kudoh, Y., Zen-Yoji, H., Matsushita, S., Sakai, S., and Maruyama, T., Outbreaks of acute enteritis due to heat-stable enterotoxin-producing strains of Esche richia coli, Microbiol. Immun. 21:175–178 (1977).Google Scholar
  54. 54.
    Levine, M. M., Bergquist, E. J., Nalin, D. R., Waterman, D. H., Hornick, R. B., Young, C. R., Sotman, S., and Rowe, R., Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive, Lancet 1:1119–1122 (1978).PubMedCrossRefGoogle Scholar
  55. 55.
    Marier, R., Wells, J. G., Swanson, R. C., Callahan, W., and Mehlman, I. J., An outbreak of enteropathogenic Escherichia coli foodborne disease traced to imported French cheese, Lancet 2:1376–1378 (1973).CrossRefGoogle Scholar
  56. 56.
    Mata, L. J., and Urrutia, J. J., Intestinal colonization of breast-fed children in a rural area of low socioeconomic level, Ann. N. Y. Acad. Sci. 176:93–109 (1971).CrossRefGoogle Scholar
  57. 57.
    Merson, M. H., Wells, J. G., Feeley, J. C., Sack, R. B., Creech, W. B., Kapikian, A. Z., Gangarosa, E. J., Morris, G. K., and Sack, R. B., Travelers’ diarrhea in Mexico: A prospective study of physicians and family members attending a congress, N. Engl. J. Med. 294:1299–1305 (1976).PubMedCrossRefGoogle Scholar
  58. 58.
    Moon, H. W., Whipp, S. C., Engstrom, G. W., and Baetz, A. L., Response of the rabbit ileal loop to cellfree products from Escherichia coli enteropathogenic for swine, J. Infect. Dis. 121:182–187 (1970).PubMedCrossRefGoogle Scholar
  59. 59.
    Neter, E., Enteritis due to enteropathogenic Escherichia coli, J. Pediatr. 55:223–239 (1959).PubMedCrossRefGoogle Scholar
  60. 60.
    Neter, E., and Shumway, C. N., E. coli serotype D433: Occurrence in intestinal and respiratory tracts, cultural characteristics, pathogenicity, sensitivity to antibiotics, Proc. Soc. Exp. Biol. Med. 75:504–507 (1950).PubMedGoogle Scholar
  61. 61.
    Newsome, P. M., Burgess, M. N., and Mullan, N. A., Effect of Escherichia coli heat-stable enterotoxin on cyclic Gmp levels in mouse intestine, Infect. Immun. 22:290–291 (1978).PubMedGoogle Scholar
  62. 62.
    O’brien, A. D., Thompson, M. R., Cantey, J. R., and Formal, S. B., Production of a Shigella dysenteriae-like toxin by pathogenic Escherichia coli (abstract), Annual Meeting of the American Society of Microbiology, New Orleans, May 8–13, 1977.Google Scholar
  63. 63.
    Ocklitz, H. W., and Schmidt, E. F., Enteropathogenic Escherichia coli serotypes: Infection of newborn through mother, Br. Med. J. 2:1036–1038 (1957).PubMedCrossRefGoogle Scholar
  64. 64.
    Ogawa, H., Nakamura, A., and Sakazaki, R., Pathogenic properties of “enteropathogenic” Escherichia coli from diarrheal children and adults, Jpn. J. Med. Sci. Biol. 21:333–349 (1968).PubMedGoogle Scholar
  65. 65.
    Pal, S. C., Rao, C. K., Kereselidze, T., Krishnaswami, A. K., Murty, D. K., Pandit, C. G., and Shrivastav, J. B., An extensive community outbreak of enteropathogenic Escherichia coli 086:B7 gastroenteritis, Bull. WHO 41:851–858 (1969).PubMedGoogle Scholar
  66. 66.
    Pickering, L. K., Dupont, H. L., Evans, D. G., Evans, D. J., Jr., and Olarte, J., Isolation of enteric pathogens from asymptomatic students from the United States and Latin American, J. Infect. Dis. 135:1003–1005 (1977).PubMedCrossRefGoogle Scholar
  67. 67.
    Pickering, L. K., Evans, D. J., Jr., Muñiou, O., Dupont, H. L., Coella-Ramirez, P., Vollet, J. J., Conklin, R. H., Olarte, J., and Kohl, S., Prospective study of enteropathogens in children with diarrhea in Houston and Mexico, J. Pediatr. 93:383–388 (1978).PubMedCrossRefGoogle Scholar
  68. 68.
    Ramsay, A. M., Acute infective diarrhoea, Br. Med. J. 2:347–350 (1968).PubMedCrossRefGoogle Scholar
  69. 69.
    Rogers, K. B., Benson, R. P., Foster, W. P., Jones, L. F., Butler, E. B., and Williams, T. C., Phthalylsulphacetamide and neomycin in the treatment of infantile gastroenteritis, Lancet 2:599–604 (1956).CrossRefGoogle Scholar
  70. 70.
    Rowe, B., Taylor, J., and Bettelheim, K. A., An investigation of travelers’ diarrhoea, Lancet 1:1–5 (1970).PubMedCrossRefGoogle Scholar
  71. 71.
    Ruiz-Palacios, G. M., Evans, D. G., Evans, D. J., Jr., and Dupont, H. L., Enzyme linked immunosorbent assay (Elisa) for detection of antibody to heat-labile enterotoxin of Escherichia coli, Abstr.Ann. Meet. Am. Soc. Microbiol. p. 60 (1978) (abstract).Google Scholar
  72. 72.
    Rutter, J. M., Burrows, M. R., Sellwood, R., and Gibbons, R. A., A genetic basis for resistance to enteric disease caused by E. coli, Nature (London) 257:135–136 (1975).CrossRefGoogle Scholar
  73. 73.
    Ryder, R. W., Wachsmuth, I. K., Buxton, A. E., Evans, D. G., Dupont, H. L., Mason, E., and Barrett, F. F. Infantile diarrhea produced by heat-stable enterotoxigenic Escherichia coli, N. Engl. J. Med. 295:849–853 (1976).Google Scholar
  74. 74.
    Sack, D. A., Kaminsky, D. C., Sack, R. B., Wamola, I. A., ørskov, F., øRskov, I., Slack, R. C. B., Arthur, R. R., and Kapikian, A. Z., Enterotoxigenic Escherichia coli diarrhea of travelers: A prospective study of American Peace Corps volunteers, Johns Hopkins Med. J. 141:64–70 (1977).Google Scholar
  75. 75.
    Sack, D. A., Mclaughlin, J. C., Sack, R. B., ørskov, F., and Kørskov, I., Enterotoxigenic Escherichia coli isolated from patients at a hospital in Dacca, J. Infect. Dis. 135:275–280 (1977).PubMedCrossRefGoogle Scholar
  76. 76.
    Sack, R. B., Gorbach, S. L., Banwell, J. G., Jacobs, B., Chatterjee, B. D., and Mitra, R., Enterotoxigenic Escherichia coli isolated from patients with severe cholera-like disease, J. Infect. Dis. 123:378–385 (1971).PubMedCrossRefGoogle Scholar
  77. 77.
    Sack, R. B., Hirschhorn, N., Brownlee, I., Cash, R. A., Woodward, W. E., and Sack, D. A., Enterotoxigenic Escherichia coli-associated diarrheal disease in Apache children, N. Engl. J. Med. 292: 1041–1045 (1975).PubMedCrossRefGoogle Scholar
  78. 78.
    Sack, R. B., Jacobs, B., and Mitra, R., Antitoxin responses to infections with enterotoxigenic Escherichia coli, J. Infect. Dis. 129:330–335 (1974).PubMedCrossRefGoogle Scholar
  79. 79.
    Sack, R. B., Sack, D. A., Mehlman, I. J., ørskov, F., and ørskov, I., Enterotoxigenic Escherichia coli isolated from food, J. Infect. Dis. 235:313–317 (1977).CrossRefGoogle Scholar
  80. 80.
    Sereny, B., Experimental shigella keratoconjunctivitis: A preliminary report, Acta Microbiol. Acad. Sci. Hung. 2:293–296 (1955).PubMedGoogle Scholar
  81. 81.
    Smith, H. W., and Gyles, C. L., The relationship between two apparently different enterotoxins produced by enteropathogenic strains of Escherichia coli of porcine origin, J. Med. Microbiol. 3:387–401 (1970).PubMedCrossRefGoogle Scholar
  82. 82.
    Smith, H. W., and Halls, S., The transmissible nature of the genetic factor in Escherichia coli that controls enterotoxin production, J. Gen. Microbiol. 52:319–334 (1968).CrossRefGoogle Scholar
  83. 83.
    Smith, H. W., and Linggood, M. A., The transmissible nature of enterotoxin production in a human enteropathogenic strain of Escherichia coli, J. Med. Microbiol. 4:301–305 (1971).PubMedCrossRefGoogle Scholar
  84. 84.
    Smith, H. W., and Linggood, M. A., Observation on the pathogenic properties of the K88, Hly and Ent plasmids of Escherichia coli with particular reference to porcine diarrhoea, J. Med. Microbiol. 4:467–485 (1971).PubMedCrossRefGoogle Scholar
  85. 85.
    Smith, M. H. D., Newell, K. W., and Sulianti, J., Epidemiology of enteropathogenic Escherichia coli infection in nonhospitalized children, Antimicrob. Agents Chemother., 5:77–83 (1965).PubMedGoogle Scholar
  86. 86.
    Taylor, J., Infectious infantile enteritis, yesterday and today, Proc. R. Soc. Med. 63:1297–1301 (1970).PubMedGoogle Scholar
  87. 87.
    Taylor, J., Powell, B. W., and Wright, J., Infantile diarrhea and vomiting: A clinical and bacteriological investigation, Br. Med. J. 2:117–125 (1949).PubMedCrossRefGoogle Scholar
  88. 88.
    Taylor, J., Wilkins, M. P., and Payne, J. M., Relations of rabbit gut reaction to enteropathogenic Escherichia coli, Br. J. Exp. Pathol. 42:43–52 (1961).PubMedGoogle Scholar
  89. 89.
    Thomson, S., Watkins, A. G., and Gray, O. P., Escherichia coli gastroenteritis, Arch. Dis. Child. 31:340–345 (1956).PubMedCrossRefGoogle Scholar
  90. 90.
    Tjoa, W., Dupont, H. L., Sullivan, P., Pickering, L. K., Holguin, A. H., Olarte, J., Evans, D. G., and Evans, D. J., Jr., Location of food consumption and travelers’ diarrhea, Am. J. Epidemiol. 106:61–66 (1977).PubMedGoogle Scholar
  91. 91.
    Trabulsi, L. R., and De Toledo, M. R. F., Escherichia coli serogroup 0115 isolated from patients with enteritis: Biochemical characteristics and experimental pathogenicity, Rev. Inst. Med. Trop. Sao Palo 11:358–362 (1969).Google Scholar
  92. 92.
    Tulloch, E. F., Jr., Ryan, K. J., Formal, S. B., and Franklin, F. A., Invasive enteropathogenic Escherichia coli dysentery: An outbreak in 28 adults, Ann. Intern. Med. 79:13–17 (1973).PubMedGoogle Scholar
  93. 93.
    Wheeler, W. E., Spread and control of Escherichia coli diarrheal disease, Ann. N. Y. Acad. Sci. 66:112–117 (1969).CrossRefGoogle Scholar
  94. 94.
    Williams, P. H., Sedgwick, M. I., Evans, N., Turner, P. J., George, R. H., and Mcneish, A. S., Adherence of an enteropathogenic strain of Escherichia coli to human intestinal mucosa is mediated by a colicinogenic conjugative plasmid, Infect. Immun. 22:392–402 (1978).Google Scholar
  95. 95.
    Yow, M. D., Melnick, J. L., Blattner,R. J., Stephenson, W. B., Robison, N. W. and Burkhardt, M. A., The association of viruses and bacteria with infantile diarrhea, Am. J. Epidemiol. 92:33–39 (1970).PubMedGoogle Scholar

Suggested Reading

  1. Dupont, H. L., Formal, S. B., Hornick, R. B., Snyder, M. J., Libonati, J. P., Sheahan, D. G., Labrec, E. H., and Kalas, J. P., Pathogenesis of Escherichia coli diarrhea. N. Engl. J. Med. 285:1–9, 1971.PubMedCrossRefGoogle Scholar
  2. Dupont, H. L., and Pickering, L. I.: Infections of the Gas- trointestinal Tract: Microbiology, Pathophysiology, and Clinical Features. Plenum Medical, New York, 1980.Google Scholar
  3. Farmer, J. J., III, Davis, B. R., Cherry, W. B., Brenner, D. J., Dowell, V. R., and Balows, A., “Enteropathogenic serotypes” of Escherichia coli which really are not, J. Pediatr. 90:1047–1049, 1977.PubMedCrossRefGoogle Scholar
  4. Marier, R. Wells, J. G., Swanson, R. C., Callahan, W., and Mehlman, I. J., An outbreak of enteropathogenic Escherichia coli foodborne disease traced to imported french cheese. Lancet 2:1376–1378, 1973.CrossRefGoogle Scholar
  5. Ryder, R. W.,Wachsmuth, I. K., Buxton, A. E., Evans, D. G., Dupont, H. L., Mason, E., and Barrett, F. F., Infantile diarrhea produced by heat-stable enterotoxigenic Escherichi, coli N. Engl. J. Med. 295:849–853, 1976.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Herbert L. DuPont
    • 1
  1. 1.Program in Infectious Diseases and Clinical MicrobiologyThe University of Texas Medical School at HoustonHoustonUSA

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