Abstract
During the last decade many in vitro systems have been developed as short-term tests for chemical, viral and physical carcinogenesis. A complete battery of such tests should include bacterial and mammalian mutagenesis, chromosome tests, DNA repair and cell transformation. These tests have been developed on the assumption that the oncogenic event is based on a genotoxic mechanism, the endpoint of which is detectable in a qualitative or quantitative way in each system.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
B. N. Ames, J. McCann, and E. Yamasaki, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test, Mut. Res., 31: 347 (1975).
U. Saffiotti, P. J. Donovan, J. M. Rice, and E. Cortesi, Mutual synergism in Salmonella mutagenesis by aflatoxin B1, benzidine, benzo[a]pyrene and safrole, Teratogenesis, Carcinogenesis, and Mutagenesis (in press).
S. A. Aaronson and G. J. Todaro, Development of 3T3-like lines from BALB/c mouse embryo cultures: transformation susceptibility to SV 40, Science, 162: 1024 (1968).
J. A. Di Paolo, K. Takano, and N. C. Popescu, Quantitation of chemically induced neoplastic transformation of BALB/3T3 cloned cell lines, Cancer Res., 32: 2686 (1970).
T. Kakunaga and J. Kamohora, Process of neoplastic transformation of cultured mammalian cell by chemical carcinogens, J. Cancer Assoc. Proc. Symp. 29th, p. 42 (1970).
T. Kakunaga and K. Miyashita, The involvement of DNA lesions and repair system in the cell transformation by chemical carcinogens, Symp. Cell Biol., Vol. 23: 95 (1972).
T. Kakunaga, A quantitative system for assay of maligant transformation by chemical carcinogens using a clone derived from BALB/3T3, Int. J. Cancer, 12: 463 (1973).
T. Kakunaga and J. D. Crow, Cell variants showing differential susceptibility to ultraviolet light-induced-transformation, Science, 209: 505 (1980).
A. Sivak et al., BALB/c-3T3 cells as target cells for chemically induced neoplastic transformation, Adv. Environ. Toxicol. (in press).
L. M. Schechtman and R. E. Kouri, Control of benzo(a)pyrene induced mammalian cell cytotoxicity, mutagenesis,and transformation by exogenous enzyme fractions, Progress in Genetic Toxicology: 307 (1977).
T. V. Zenser, M. B. Mattammal, H. J. Armbrecht, and B. B. David, Benzidine binding to nucleic acids mediated by the per-oxidative activity of prostaglandin endoperoxidase synthetase, Cancer Res., 40: 2839 (1980).
E. Cortesi, U. Saffiotti, P. J. Donovan, J. M. Rice, and T. Kakunaga, Dose–response studies on neoplastic transformation of BALB/c 3T3 clone A31–1–1 cells by aflatoxin Bi, benzidine, benzo(a)pyrene, 3–methylcholantrene and N–methyl–N’–nitro–Nnitrosoguanidine, Teratogenesis, Carcinogenesis, and Muta–genesis (in press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cortesi, E. (1983). In Vitro Studies on Chemical Carcinogenesis in BALB/c 3T3 Cells. In: Castellani, A. (eds) The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1117-2_46
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1117-2_46
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1119-6
Online ISBN: 978-1-4757-1117-2
eBook Packages: Springer Book Archive