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DNA Fragmentation and Sister Chromatid Exchanges Induced by Commercial Auramine O, Purified Auramine, and Michler’s Ketone

  • D. Vecchio
  • M. Pala
  • P. Russo
  • L. Ottaggio
  • A. Albini
  • S. Parodi
  • L. Santi

Abstract

In IARC monograph No. 1 (IARC monograph, 1972) Auramine O is reported to be widely used in industry. An high increase in bladder tumors in workers engaged in the manufacture of Auramine was reported (Case and Pearson, 1954). A recent study (Report of a IARC Working Group, 1980) evaluated the data on human and experimental animal carcinogenesis. Auramine was classified in group 2, probably carcinogenetic for humans, subgroup B, lower degree of evidence.

Keywords

Bone Marrow Cell Bladder Tumor Sister Chromatid Exchange Major Spot Male Swiss Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • D. Vecchio
    • 1
    • 3
  • M. Pala
    • 1
    • 3
  • P. Russo
    • 1
    • 3
  • L. Ottaggio
    • 1
    • 3
  • A. Albini
    • 1
    • 3
  • S. Parodi
    • 2
  • L. Santi
    • 2
  1. 1.Istituto Nazionale per la Ricerca sul CancroGenoaItaly
  2. 2.Department of OncologyGenoa UniversityItaly
  3. 3.Istituto Scientifico per lo Studio e la Cura dei TumoriItaly

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