DNA Fragmentation and Sister Chromatid Exchanges Induced by Commercial Auramine O, Purified Auramine, and Michler’s Ketone
In IARC monograph No. 1 (IARC monograph, 1972) Auramine O is reported to be widely used in industry. An high increase in bladder tumors in workers engaged in the manufacture of Auramine was reported (Case and Pearson, 1954). A recent study (Report of a IARC Working Group, 1980) evaluated the data on human and experimental animal carcinogenesis. Auramine was classified in group 2, probably carcinogenetic for humans, subgroup B, lower degree of evidence.
KeywordsBone Marrow Cell Bladder Tumor Sister Chromatid Exchange Major Spot Male Swiss Mouse
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