Genetic Bioassay Data on Some Known or Suspected Human Carcinogens

  • Michael D. Waters
  • Neil E. Garrett
  • Christine M. Covone-de Serres
  • Barry E. Howard
  • H. Frank Stack


The purpose of this report is to summarize the currently available qualitative information, obtained from genetic and related bioassay systems, on 24 agents or groups of agents. These agents have been classified by the International Agency for Research on Cancer (IARC) as (1) known human carcinogens, (2) probable human carcinogens, or (3) unclassified carcinogens.1,2 The intent is to examine the performance of genetic bioassay systems in the detection and evaluation of compounds for which there is some evidence of human carcinogenic potential. These compounds are of particular interest, in a retrospective sense, for purposes of relating evidence of carcinogenic effects in man and in experimental animals with the qualitative data base being assembled using short-term genetic bioassays. Ideally, it would be important to determine the quantitative response of genetic bioassays as a function of chemical dose and to relate these responses to quantitative evidence of carcinogenic and mutagenic effects in experimental animals. Such a quantitative evaluation is essential if we are to properly select from among the many chemicals active in short-term genetic bioassays those that should be subjected to further evaluation. Ultimately, quantitative evaluations of genetically mediated effects must be coupled with accurate estimates of dose to the DNA, since this combination of information forms the basis of all current models for quantitative risk assessment.


Ethylene Oxide Vinyl Chloride Human Carcinogen Micronucleus Test Vinyl Chloride Monomer 


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Michael D. Waters
    • 1
  • Neil E. Garrett
    • 2
  • Christine M. Covone-de Serres
    • 3
  • Barry E. Howard
    • 1
  • H. Frank Stack
    • 2
  1. 1.Genetic Toxicology Division Health Effects Research LaboratoryU.S. Environmental Protection AgencyResearch Triangle ParkUSA
  2. 2.Environmental SciencesNorthrop Services, Inc.Research Triangle ParkUSA
  3. 3.Genetics CurriculumUniversity of North CarolinaChapel HillUSA

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