Electrophilic Reactivity as a Measure of Genotoxic Potency

  • Lars Ehrenberg
  • Siv Osterman-Golkar


The mutagenic effectiveness in forward mutation systems of a number of monofunctional alkylating agents with large differences in absolute reactivity and with different s-values (Swain and Scott, 1953) have been compared in the low-dose region of the dose-response curves. It was shown that the mutation frequency, R, at equal dose, D* (D is the time integral of the concentration of the alkylating agent, RX), was proportional to the second order rate constant, kn=2, for reaction with some nucleophilic center with a low nucleophilic strength (n=2 in the Swain-Scott scale, see Fig. 1) (Hussain and Ehrenberg, 1975; Osterman-Golkar, 1975; Ehrenberg, 1980; Hussain, 1981)


Alkylating Agent Sufficient Criterion Electrophilic Reactivity Acyl Halide Mutagenic Effectiveness 


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Lars Ehrenberg
    • 1
  • Siv Osterman-Golkar
    • 1
  1. 1.Department of Radiobiology, Wallenberg LaboratoryUniversity of StockholmStockholmSweden

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