Dosimetry by Means of Measurement of Hemoglobin Alkylation and Risk Estimation Based on the Rad-Equivalent Approach

  • S. Osterman-Golkar


To assist the regulatory agencies in protecting the public health it is not sufficient to identify genetic risk factors. As a basis for measures, such as setting of TLV, data have to be provided that make possible a prediction of the relation between the level of exposure and extent of the damage to human health. Despite extensive biological experimentation there is very little data which can be directly used in quantitative risk assessment of genotoxic compounds. The possibilities of estimating risk to man from experimental data are limited, especially, by lack of knowledge of qualitative and quantitative differences between experimental organisms and man in metabolism of foreign compounds and in efficiencies of repair functions. A further drawback of tests for genotoxic activity of conventional scope is a low resolving power. If for some reason, such as a high toxicity or low solubility, a compound cannot be investigated at doses much higher than the one that occurs in human environments, an unacceptable risk may well be hidden in a negative result (Ehrenberg, 1974, 1977; Ehrenberg and OstermanGolkar, 1980).


Ethylene Oxide Vinyl Chloride Benzyl Chloride Ethyl Methanesulfonate Quantitative Risk Assessment 


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • S. Osterman-Golkar
    • 1
  1. 1.Radiology Department Wallenberg LaboratoryUniversity of StockholmStockholmSweden

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