Lipoxins of the 5-Series Derived from Eicosapentaenoic Acid
Arachidonic acid released from membrane phospholipids during cell activation is metabolised by the cyclo-oxygenase pathway to prostaglandins and thromboxanes and by the 5-lipoxygenase pathway to leukotrienes. In the 5-lipoxygenase pathway, arachidonic acid is metabolised through two sequential intermediates, 5-hydroperoxy eicosatetraenoic acid (5-HPETE) and leukotriene A4 (LTA4), to leukotriene B4 (LTB4) and to leukotriene C4 (LTC4) and its conversion products, leukotriene D4 (LTD4) and leukotriene E4 (LTE4).
KeywordsArachidonic Acid Eicosapentaenoic Acid Allylic Alcohol Lysozyme Release LTA4 Hydrolase
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