Lipoxins pp 147-154 | Cite as

Lipoxins of the 5-Series Derived from Eicosapentaenoic Acid

  • Bernd W. Spur
  • Crawford Jacques
  • Attilio E. Crea
  • Tak H. Lee


Arachidonic acid released from membrane phospholipids during cell activation is metabolised by the cyclo-oxygenase pathway to prostaglandins and thromboxanes and by the 5-lipoxygenase pathway to leukotrienes. In the 5-lipoxygenase pathway, arachidonic acid is metabolised through two sequential intermediates, 5-hydroperoxy eicosatetraenoic acid (5-HPETE) and leukotriene A4 (LTA4), to leukotriene B4 (LTB4) and to leukotriene C4 (LTC4) and its conversion products, leukotriene D4 (LTD4) and leukotriene E4 (LTE4).


Arachidonic Acid Eicosapentaenoic Acid Allylic Alcohol Lysozyme Release LTA4 Hydrolase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Bernd W. Spur
    • 1
  • Crawford Jacques
    • 1
  • Attilio E. Crea
    • 1
  • Tak H. Lee
    • 1
  1. 1.Department of Medicine UMDSGuy’s HospitalLondon SE1UK

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