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Kinins—II pp 555-567 | Cite as

Participation of Kallikrein, Coagulation/Fibrinolysis Parameters in the Development of Glomerulonephritis

  • Kazumichi Nakamura
  • Mutsuyoshi Kazama
  • Takeshi Abe
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Masugi nephritis was induced in dogs in which platelet count, fibrinogen, antithrombin activity, plasma prekallikrein and immediate plasmin inhibitors were coincidentally decreased immediately after the injection of nephrotoxic serum. It was found that the grade of decrease of urinary kallikrein excretion following these immediate reactions were parallel with the grade of renal damages. By the pretreatment with heparin or the defibrination with snake venom, however, the histological findings of Masugi nephritis showed rather severe damage.

Based on the consumption of coagulation factors, kallikrein, kinin and their inhibitors in the development of this nephritis, it was postulated that inauguration of coagulation and activation of kallikrein contributed to the development of glomerulonephritis. The treatment or prevention of this coagulation process with heparin or snake venom, however, gave untoward effects on the pathological process in this experiment.

Keywords

Snake Venom Coagulation Process Proliferative Glomerulonephritis Crescent Formation Antithrombin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Kazumichi Nakamura
    • 1
  • Mutsuyoshi Kazama
    • 1
  • Takeshi Abe
    • 1
  1. 1.Department of MedicineTeikyo University School of MedicineItabashi-ku, Tokyo 173Japan

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