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Kinins—II pp 425-437 | Cite as

Significance of Adrenergic α-Effect on Salivary Kallikrein Secretion in the Submandibular Gland of the Dog

  • T. Kudo
  • Y. Kotani
  • M. Oka
  • K. Matsumoto
  • R. Inoki
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

The effects of the sympathetic nerve stimulation and the administrations of sympathomimetics on the secretion of salivary kallikrein induced by the chorda tympani stimulation were examined quantitatively and qualitatively in the submandibular gland of the dog. The secretion of salivary kallikrein may be mediated through both adrenergic α- and β-receptors. The activities of salivary kallikrein secreted by either the chorda tympani stimulation or isoproterenol were riot inhibited by soy bean trypsin inhibitor in vitro, but those secreted by the sympathetic nerve stimulation and noradrenaline or adrenaline were markedly inhibited in vitro. These results suggested that secretion of glandular kallikrein was induced by the chorda tympani. stimulation and the sympathetic β-stimulation, and secretion of plasma kallikrein was induced by the sympathetic α-stimulation.

Keywords

Sympathetic Nerve Submandibular Gland Zymogen Granule Salivary Amylase Acta Physiol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • T. Kudo
    • 1
  • Y. Kotani
    • 1
  • M. Oka
    • 1
  • K. Matsumoto
    • 1
  • R. Inoki
    • 1
  1. 1.Department of PharmacologyOsaka University Dental SchoolOsakaJapan

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