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Kinins—II pp 363-372 | Cite as

Studies on Kallikrein-Kinin System in Bovine Lung

  • K. Horiuchi
  • J. Ishikawa
  • M. Manabe
Part of the Advances in Experimental Medicine and Biology book series (AEMB)

Abstract

Kinins are liberated from their precursor proteins by specific hydrolysis of kinin-forming enzymes. In blood, there exist two precursors, the high molecular weight (HMW) kininogen and the low molecular weight (LMW) kininogen, whose molecular weights are 76,000 and 49,500, respectively (Yano et al., 1967; Komiya et al., 1974; Nagasawa et al., 1966). Pancreatic kallikrein forms kinins from both kininogens, while plasma kallikrein acts only on the HMW kininogen (Nagasawa et al., 1967; Yano et a1., 1971). This finding triggered the idea that in the blood system the genuine substrate of plasma kallikrein could be HMW kininogen, and the role of LMW kininogen has been discussed.

Keywords

Ammonium Sulfate Fraction Bovine Plasma Plasma Kallikrein High Molecular Weight Kininogen Bovine Lung 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • K. Horiuchi
    • 1
  • J. Ishikawa
    • 1
  • M. Manabe
    • 1
  1. 1.Department of Biochemistry, Faculty of Pharmaceutical SciencesTokushima University of Arts and ScienceYamashiro-cho, Tokushima 770Japan

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