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The Role of the Phosphatidylinositol Cycle in the Activation of the Frog Egg

  • Richard Nuccitelli
  • James Ferguson
  • Jin-Kwan Han

Abstract

Over the past five years we have filled in many steps in the sequence of events responsible for the activation of both vertebrate and invertebrate eggs. While the egg of the sea urchin has been the most popular system for the study of gamete activation, several investigators have been studying vertebrate eggs as well. The amphibian egg has emerged as the best studied vertebrate model to date. We now know that the activation events following normal fertilization in this egg include the phosphatidylinositol lipid cascade. We will review some of these recent observations here and will then concentrate on current studies from our laboratory that indicate a possible role for at least two of the phosphoinositols in the cascade.

Keywords

Inositol Trisphosphate Cortical Granule Quiescent Period Fertilization Potential Animal Hemisphere 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Richard Nuccitelli
    • 1
  • James Ferguson
    • 1
  • Jin-Kwan Han
    • 1
  1. 1.Department of ZoologyUniversity of California, DavisDavisUSA

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