Brain Edema

  • Pak Hoo Chan
  • Robert A. Fishman

Abstract

Brain edema accompanies a wide variety of pathological processes. It contributes to the morbidity and mortality of many neurological diseases, including head injury, stroke, brain tumor, cerebral infections (e. g., brain abscess, encephalitis, and meningitis), lead encephalopathy, hypoxia, hypoosmolality, disequilibrium syndromes associated with dialysis and diabetic ketoacidosis, and some forms of obstructive hydrocephalus. Although many aspects of the pathophysiology of brain edema have been clarified,1–7 the molecular mechanisms and biochemical events that underlie the formation of edema are poorly understood. This chapter reviews current hypotheses concerning the development of brain edema and its potential drug therapy.

Keywords

Permeability Superoxide Selenium Shrinkage Testosterone 

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Pak Hoo Chan
    • 1
  • Robert A. Fishman
    • 1
  1. 1.Department of NeurologyUniversity of California School of MedicineSan FranciscoUSA

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