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Peptides and Brain Pathology

  • John E. Morley
  • Charles J. Billington

Abstract

Over 30 different peptides have been identified in the central nervous system.1 Thus, any investigation of the role of neuropeptides in pathology is certain to produce variety and diversity. The explosive rate at which new neuropeptides have been discovered over the last decade has meant that our understanding of their possible functions in the central nervous system has lagged far behind. It seems clear that the neuropeptides along with amino acids and monoamines play an integral role as neurotransmitters in the communication network of the brain. Thus, the discovery of abnormalities in the synthesis, release, or receptor binding of the neuropeptides appears to offer the keys to unlocking many of the secrets of neurological and psychiatric disease. At present, however, our knowledge of the pathophysiological processes in which neuropeptides are involved is rudimentary. In this chapter we attempt to place in perspective some of the exciting glimpses of the role of peptides in brain pathology that have been obtained over the past few years. Also, making use of the known effects of neuropeptides in animals, we attempt to pinpoint the areas in which it appears most likely that neuropeptides will be found to play an important role in pathological processes.

Keywords

Anorexia Nervosa Opioid Peptide Brain Pathology Opiate Receptor Biological Psychiatry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John E. Morley
    • 1
  • Charles J. Billington
    • 2
  1. 1.Neuroendocrine Research LaboratoryVeterans Administration Medical CenterMinneapolisUSA
  2. 2.Division of Endocrinology, Department of MedicineUniversity of MinnesotaMinneapolisUSA

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