Neurochemical Aspects of Schizophrenia

  • Lynn Eleanor DeLisi
  • Richard Jed Wyatt


Schizophrenia, a syndrome characterized by delusions, hallucinations, and disturbances of thought, is one of the most pervasive and socially disabling of all psychiatric disorders. Approximately 27% of annual psychiatric hospital admissions (340,000) in the United States are patients with this disorder,1 and most individuals with a chronic schizophrenic illness, if not institutionalized, are unemployable and spend years in community care facilities. Despite the severe morbidity and relatively high prevalence of this disorder in the general population (approximately 1%),2 its etiology remains unknown. In the postwar years, schizophrenia research focused on putative psychodynamic and socioenvironmental vulnerabilities for development of this disorder. Severely disordered mother-infant relationships as well as pathological communication patterns among family members were, in some psychiatric circles, considered important environmental inducers of schizophrenia. Terms such as “schizophrenigenic mother,”3 “double bind,” and “schism”4,5 were used to describe these pathological relationships. There is no doubt that disturbed relationships within some, but no all, families of schizophrenics are accurate observations, although how these stressors are associated with the etiology of schizophrenia remains obscure. Nevertheless, decreasing familial and other social stresses has been demonstrated to be an extremely important treatment strategy.6


Schizophrenic Patient Fusaric Acid Schizophrenic Symptom Neuroleptic Medication Chronic Schizophrenic Patient 


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  1. 1.
    Rosenstein, M. J., and Milazzo-Sayre, L. J., 1975, Mental Health Service System Reports, U.S. Department of Health and Human Services, NIMH, Division of Biometry and Epidemiology, Survey and Reports Branch, Rockville, Maryland, p. 45.Google Scholar
  2. 2.
    World Health Organization, 1975, Public Health Papers No. 63, Schizophrenia: A Multinational Study, World Health Organization, Geneva, pp. 35–38.Google Scholar
  3. 3.
    Fromm-Reichmann, F., 1948, Psychiatry 11:263–273.PubMedGoogle Scholar
  4. 4.
    Lidz, T., Cornelison, A. R., Fleck, S., and Terry, D., 1957, Psychiatry 20:329–342.PubMedGoogle Scholar
  5. 5.
    Singer, M. T., and Wynne, L. C., 1966, Psychiatr. Res. Rep. 20:25–38.Google Scholar
  6. 6.
    Keith, S. J., and Matthews, S. M., 1982, Psychiatry: 1982, The American Psychiatric Association Annual Review (L. Grinspoon, ed.), American Psychiatric Press, Washington, pp. 166–178.Google Scholar
  7. 7.
    Faucault, M., 1967, Madness and Civilization, Tavistock Publications, London.Google Scholar
  8. 8.
    Tusques, J., 1937, Sem. Hop. Paris 13:109–111.Google Scholar
  9. 9.
    Kalinowsky, L. B., and Hippius, H., 1969, Pharmacological, Convulsive, and Other Somatic Treatments in Psychiatry, Grunne & Stratton, New York.Google Scholar
  10. 10.
    Dorland’s Illustrated Medical Dictionary, 1965, (J. P. Friel, ed.), W. B. Saunders, Philadelphia.Google Scholar
  11. 11.
    Carlsson, A., 1978, Am. J. Psychiatry 135:164–173.Google Scholar
  12. 12.
    Rosenthal, D. and Kety, S. S., eds., 1968, The Transmission of Schizophrenia, Pergamon Press, Oxford.Google Scholar
  13. 13.
    Gottesman, I. I., and Shields, J., 1982, Schizophrenia: The Epigenetic Puzzle, Cambridge University Press, Cambridge.Google Scholar
  14. 14.
    Knox, W. E., 1972, The Metabolic Basis of Inherited Disease, 3rd edition (J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), McGraw-Hill, New York, p. 266.Google Scholar
  15. 15.
    Teuber, H. L., 1972, Neurosci. Res. Prog. Bull. 10(4):381–388.Google Scholar
  16. 16.
    Penfield, W., and Jasper, G., 1954, Epilepsy and the Functional Anatomy of the Human Brain, Little, Brown, Boston.Google Scholar
  17. 17.
    Mullan, S., and Penfield, W., 1959, Arch. Neurol. Psychiatry 81:269–284.CrossRefGoogle Scholar
  18. 18.
    Bazhin, E. F., Wasserman, L. I., and Tonkonogii, I. M., 1975, Neuropsychologia 13:481–487.PubMedCrossRefGoogle Scholar
  19. 19.
    Abrams, R., and Taylor, M. A., 1979, Arch. Gen. Psychiatry 36:1355–1358.PubMedCrossRefGoogle Scholar
  20. 20.
    Flor-Henry, P., 1976, Ann. N.Y. Acad. Sci. 280:777–797.PubMedCrossRefGoogle Scholar
  21. 21.
    Stevens, J. R., Bigelow, L., Denney, D., Lipkin, J., Livermore, A. H., Rauscher, F., Wyatt, R. J., 1979, Arch. Gen. Psychiatry 36:251–262.PubMedCrossRefGoogle Scholar
  22. 22.
    Itil, T. M., 1977, Schizophren. Bull. 3:61–79.CrossRefGoogle Scholar
  23. 23.
    Fenton, G. W., Fenwick, P. B. C., Dollimore, J., Dunn, T. L., and Hirsch, S. R., 1980, Br. J. Psychiatry 136:445–455.PubMedCrossRefGoogle Scholar
  24. 24.
    Buchsbaum, M. S., King, A. C., Cappelletti, J., Coppola, R., van Kammen, D. P., 1982, Adv. Biol. Psychiatry 9:50–56.Google Scholar
  25. 25.
    Malitz, S., Lozzi, V., and Kanzler, M., 1969, Schizophrenia: Current Concepts and Research (D. V. Siva Sankar, ed.), P. J. D. Publications, Hicksville, New York, pp. 273–302.Google Scholar
  26. 26.
    Buchsbaum, M. S., Ingvar, D. H., Kessler, R., Waters, R. N., Cappelletti, J., van Kammen, D. P., King, A. C., Johnson, J. L., Manning, R. G., Flynn, R. W., Mann, L. S., Bunney, W. E., and Sokoloff, L., 1982, Arch. Gen. Psychiatry 39:251–259.PubMedCrossRefGoogle Scholar
  27. 27.
    Ingvar, D. H., and Frazen, G., 1974, Acta Psychiatr. Scand. 50:425–462.PubMedCrossRefGoogle Scholar
  28. 28.
    DeLisi, L. E., and Buchsbaum, M. S. Biol. Psychiatry (in press).Google Scholar
  29. 29.
    Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J., and Kreel, L., 1976, Lancet 2:924–926.PubMedCrossRefGoogle Scholar
  30. 30.
    Weinberger, D. R., and Wyatt, R. J., 1982, Biological Markers in Psychiatry and Neurology (I. Hanen and E. Usdin, eds.), Pergamon Press, New York, pp. 505–512.Google Scholar
  31. 31.
    Stevens, J. R., 1982, Arch. Gen. Psychiatry 39:1131–1139.PubMedCrossRefGoogle Scholar
  32. 32.
    Fisman, M., 1975, Br. J. Psychiatry 126:414–422.PubMedCrossRefGoogle Scholar
  33. 33.
    Kandel, E. R., and Schwartz, J. H., 1981, Principles of Neural Science, Elsevier/North-Holland, New York.Google Scholar
  34. 34.
    Cooper, J. R., Bloom, F. E., and Roth, R. H., 1982, The Biochemical Basis of Neuropharmacology, Oxford University Press, New York.Google Scholar
  35. 35.
    Young, D., and Scoville, W. B., 1938, Med. Clin. North Am. 22:637–646.Google Scholar
  36. 36.
    Connell, P. H., 1958, Maudsley Monographs No. 5., Oxford University Press, London.Google Scholar
  37. 37.
    Griffith, J. D., Cavanaugh, J. H., and Oates, J. A., 1970, Psychotomimetic Drugs (D. H. Efron, ed.), Raven Press, New York.Google Scholar
  38. 38.
    Janowsky, D., and Davies, J., 1976, Arch. Gen. Psychiatry 33:304–308.PubMedCrossRefGoogle Scholar
  39. 39.
    Woodrow, K. M., Reifman, A., and Wyatt, R. J., 1978, Neuropharmacology and Behavior (B. Haber and M. H. Aprison, eds.), Plenum Press, New York, pp. 1–22.CrossRefGoogle Scholar
  40. 40.
    Wyatt, R. J., Potkin, S. G., Kleinman, J. E., Weinberger, D. R., Luchins, D. L., and Jeste, D. V., 1981, J. Nerv. Ment. Dis. 169:100–112.PubMedCrossRefGoogle Scholar
  41. 41.
    van Kammen, D. P., Bunney, W. E., Docherty, J. P., Marder, S. R., Ebert, M. H., Rosenblatt, J. E., and Rayner, J. N., 1982, Am. J. Psychiatry 139:991–997.PubMedGoogle Scholar
  42. 42.
    Frye, P. E., Pariser, S. F., Kim, M., and O’Shaughnessy, R. W., 1982, J. Clin. Psychiatry 43:252–253.PubMedGoogle Scholar
  43. 43.
    Carlsson, A., 1974, J. Psychiatr. Res. 11:57–64.PubMedCrossRefGoogle Scholar
  44. 44.
    Corsini, G. U., Del Zompo, M., Manconi, S., Piccardi, M. P., Onali, P. L., and Mangoni, A., 1977, Adv. Biochem. Psychopharmacol. 16:645–648.PubMedGoogle Scholar
  45. 45.
    Smith, R. C., Tamminga, C., and Davis, J. M., 1977, J. Neural Transm. 40(2):171–176.PubMedCrossRefGoogle Scholar
  46. 46.
    Tamminga, C. A., Schaffer, M. H., Smith, R. C., and Davis, J. M., 1978, Science 200(4341):567–568.PubMedCrossRefGoogle Scholar
  47. 47.
    Bird, E. D., Crow, T. J., Iverson, L. L., Longden, A., Mackay, A. V. P., Riley, G. J., and Spokes, E. C., 1979 J. Physiol. (Lond.) 293:36–37P.Google Scholar
  48. 48.
    Kleinman, J. E., Karoum, F., Rosenblatt, J. E., Gillin, J. C., Hong, J., Bridge, T. P., Zalcman, S., Storch, F., del Carmen, R., and Wyatt, R. J., 1982, Biological Markers in Psychiatry and Neurology (I. Hanin and E. Usdin, eds.), Pergamon Press, Oxford, pp. 67–78.Google Scholar
  49. 49.
    Bird, E. D., Spokes, E. G., Barnes, J., Mackay, A., Iversen, L., and Shepherd, M., 1977, Lancet 2:1157–1159.PubMedCrossRefGoogle Scholar
  50. 50.
    Owen, F., Cross, A. J., Crow, T. J., Longden, A., Poulter, M., and Riley, G. J., 1978, Lancet 2:223–225.PubMedCrossRefGoogle Scholar
  51. 51.
    Bird, E. D., Spokes, E. G., and Iversen, L. L., 1979, Science 204:93–94.PubMedCrossRefGoogle Scholar
  52. 52.
    Mackay, A. V. P., Iverson, L. L., Rossor, M., Spokes, E., Bird, E., Arregui, A., Creese, I., and Snyder, S. H., 1982, Arch. Gen. Psychiatry 39:991–997.PubMedCrossRefGoogle Scholar
  53. 53.
    Lee, T., and Seeman, P., 1980, Am. J. Psychiatry 137:191–197.PubMedGoogle Scholar
  54. 54.
    Schwartz, J. C., Baudry, M., Markes, M. P., Costentin, J., and Protais, P., 1978, Life Sci. 23:1785–1790.PubMedCrossRefGoogle Scholar
  55. 55.
    Crow, T. J., Cross, A. J., Johnstone, E. C., and Owen, F., 1982, Schizophrenia As a Brain Disease (F. A. Henn and H. A. Nasrallah, eds.), Oxford University Press, New York, pp. 196–234.Google Scholar
  56. 56.
    Burt, D. R., Creese, I., and Snyder, S. H., 1977, Science 197:326–328.CrossRefGoogle Scholar
  57. 57.
    Clow, A., Theodorou, A., Jenner, P., and Marsden, C. D., 1980, Eur. J. Pharmacol. 63:135–144.PubMedCrossRefGoogle Scholar
  58. 58.
    Owen, F., Cross, A. J., Waddington, J. L., Poulter, M., Gamble, S. J., and Crow, T. J., 1980, Life Sci. 26:55–59.PubMedCrossRefGoogle Scholar
  59. 59.
    Reisine, T. D., Fields, J. Z., Bird, E. D., Spokes, E., and Yamamura, H. I., 1978, Commun. Psychopharmacol. 2:79–84.PubMedGoogle Scholar
  60. 60.
    Haracz, J. L., 1982, Schizophren. Bull. 8:438–469.CrossRefGoogle Scholar
  61. 61.
    Muller, E. E., Nistico, G., and Scapagini, E., 1977, Neurotransmitters and Anterior Pituitary Function, Academic Press, New York.Google Scholar
  62. 62.
    Meltzer, H. Y., and Fang, V. S., 1976, Arch. Gen. Psychiatry 33:279–286.PubMedCrossRefGoogle Scholar
  63. 63.
    Laughren, T. P., Brown, W. A., and Williams, B. W., 1979, Am. J. Psychiatry 136:108–110.PubMedGoogle Scholar
  64. 64.
    Brown, W. A., and Laughren, T. P., 1981, Am. J. Psychiatry 138:237–239.PubMedGoogle Scholar
  65. 65.
    Meltzer, H. Y., Sachar, E. J., and Frantz, A. G., 1974, Arch. Gen. Psychiatry 31:564–569.PubMedCrossRefGoogle Scholar
  66. 66.
    Mackay, A. V. P., 1980, Br. J. Psychiatry 137:379–383.PubMedCrossRefGoogle Scholar
  67. 67.
    Chouinard, G., and Jones, B. D., 1978, Lancet 2:99–100.PubMedCrossRefGoogle Scholar
  68. 68.
    Wyatt, R. J., 1984, The Stanley R. Dean Research Aware Lecture (in press).Google Scholar
  69. 69.
    Crow, T. J., 1980, Br. Med. J. 280:66–68.PubMedCrossRefGoogle Scholar
  70. 70.
    Crow, T. J., 1981, Br. J. Psychiatry 139:251–254.PubMedCrossRefGoogle Scholar
  71. 71.
    Kleinman, J. E., Weinberger, D. R., Rogol, D. A., Bigelow, L. B., Klein, S. T., and Wyatt, R. J., 1982, Arch. Gen. Psychiatry 39:655–657.PubMedCrossRefGoogle Scholar
  72. 72.
    Andreasen, N. C., Olsen, S. A., Dennert, J. W., and Smith, M. R., 1982, Am. J. Psychiatry 132:297–302.Google Scholar
  73. 73.
    Jeste, D. V., Zalcman, S., Weinberger, D. R., Bigelow, L. B., Kleinman, J. E., Rogol, A., Gillin, J. C., and Wyatt, R. J., 1983, Prog. Neuropsychopharmacol. Biol. Psychiatry 7:83–88.PubMedCrossRefGoogle Scholar
  74. 74.
    Wise, R. A., 1982, Behav. Brain Sci. 5:39–87.CrossRefGoogle Scholar
  75. 75.
    Siegfried, B., and Bures, J., 1979, Brain Res. 167:139–155.PubMedCrossRefGoogle Scholar
  76. 76.
    Fink, S. J., and Smith, G. P., 1980, Brain Res. 199:359–384.PubMedCrossRefGoogle Scholar
  77. 77.
    Wooley, D. W., and Shaw, E., 1953, Proc. Natl. Acad. Sci. U.S.A. 40(4):228–231.CrossRefGoogle Scholar
  78. 78.
    Wooley, D. W., 1962, The Biochemical Bases of Psychoses or the Serotonin Hypotheses about Mental Illness, John Wiley and Sons, New York, pp. 168–179.Google Scholar
  79. 79.
    Haverback, B. J., Sjoerdsma, A., and Terry, L. L., 1956, N. Engl. J. Med. 255:270–274.PubMedCrossRefGoogle Scholar
  80. 80.
    Feldstein, A., Hoagland, H., and Freeman, H., 1958, Science 128:358.PubMedCrossRefGoogle Scholar
  81. 81.
    Toh, C. C., 1954, J. Physiol. (Lond.) 126:248–254.Google Scholar
  82. 82.
    Garelis, E., Gillin, J. C., Wyatt, R. J., and Neff, N., 1975, Am. J. Psychiatry 132:184–186.PubMedGoogle Scholar
  83. 83.
    DeLisi, L. E., Neckers, L. M., Weinberger, D. R., and Wyatt, R. J., 1981, Arch. Gen. Psychiatry 38:647–654.PubMedCrossRefGoogle Scholar
  84. 84.
    Freedman, D. X., Belenduik, K., Belenduik, G. W., and Crayton, J. W., 1981, Arch. Gen. Pscyhiatry 38:655–659.CrossRefGoogle Scholar
  85. 85.
    Feldstein, A., Hoagland, H., and Freeman, H., 1959, J. Nerv. Ment. Dis. 129:62–68.PubMedCrossRefGoogle Scholar
  86. 86.
    Jus, A., Laskowska, D., and Zimny, S., 1958, Ann. Med. Psychol. (Paris) 116:898–913.Google Scholar
  87. 87.
    Coleman, M., Hart, P. N., and Randall, J., 1977, Neuropaediatrie 8:459–466.CrossRefGoogle Scholar
  88. 88.
    Post, R. M., Ballenger, J. C., and Goodwin, F. K., 1980, Neurobiology of Cerebrospinal Fluid (J. H. Wood, ed.), Plenum Press, New York, pp. 685–717.CrossRefGoogle Scholar
  89. 89.
    Potkin, S. G., Weinberger, D. R., Linnoila, M., and Wyatt, R. J., 1983, Am. J. Psychiatry 140:21–25.PubMedGoogle Scholar
  90. 90.
    Joseph, M. H., Baker, H. F., Crow, T. J., Riley, G. J., and Risby, D., 1979, Psychophar-macology 62:279–275.CrossRefGoogle Scholar
  91. 91.
    Crow, T. J., Baker, H. F., Cross, A. J., Joseph, M. H., Lofthouse, R., Longden, A., Owen, F., Riley, G. J., Glover, V., and Killpack, W. S., 1979, Br. J. Psychiatry 134:249–256.PubMedCrossRefGoogle Scholar
  92. 92.
    Farley, I. J., Shannak, K. S., and Hornykiewicz, O., 1980, Receptors for Neurotransmitters and Peptides Hormones (G. Pepeu, M. J. Kuhar, and S. J. Enna, eds.), Raven Press, New York, pp. 427–433.Google Scholar
  93. 93.
    Winblad, B., Bucht, G., Gottfries, C. G., and Roos, B. E., 1979, Acta Psychiatr. Scand. 60:17–28.PubMedCrossRefGoogle Scholar
  94. 94.
    Ahtee, L., and Paasonen, M. K., 1968, Ann. Mod. Exp. Biol. Fenn. 46:416–422.Google Scholar
  95. 95.
    Todrick, A., and Tait, A. C., 1969, J. Pharm. Pharmacol. 21:751–762.PubMedCrossRefGoogle Scholar
  96. 96.
    Oxenkrug, G. F., 1978, J. Pharm. Pharmacol. 30:740.PubMedCrossRefGoogle Scholar
  97. 97.
    Bacopoulos, N. G., Redmond, D. E., and Roth, R. H., 1979, J. Neurochem. 32(4): 1215–1218.PubMedCrossRefGoogle Scholar
  98. 98.
    Lauer, J. W., Inskip, W. M., Bernsohn, J., and Zeller, E. A., 1958, Arch. Neurol. Psychiatry 80(1): 122–130.CrossRefGoogle Scholar
  99. 99.
    Kopin, I. J., 1959, Science 129:(3352):835–836.PubMedCrossRefGoogle Scholar
  100. 100.
    Shaw, C. R., Lucas, J., and Rabinovitch, R. D., 1959, Arch. Gen. Psychiatry 1(4):366–371.CrossRefGoogle Scholar
  101. 101.
    Wooley, D. W., 1962, The Biochemical Bases of Psychoses or the Serotonin Hypothesis about Mental Illness, New York, John Wiley and Sons, pp. 168–170.Google Scholar
  102. 102.
    Klee, G. D., Bertino, J., Goodman, A., and Aronson, H., 1961, J. Ment. Sci. 106(442):309–316.Google Scholar
  103. 103.
    Hoagland, H., 1958, J. Nerv. Ment. Dis. 126(3):211–220.PubMedCrossRefGoogle Scholar
  104. 104.
    Pollin, W., Cardon, P. V., Jr., and Kety, S. S., 1961, Science 133(3446): 104–105.PubMedCrossRefGoogle Scholar
  105. 105.
    Bigelow, L. B., Walls, P., Gillin, J. C., and Wyatt, R. J., 1979, Biol. Psychiatry 14:53–67.PubMedGoogle Scholar
  106. 106.
    Sherwood, S. L., 1955, Proc. R. Soc. Med. 48(10):855–863.Google Scholar
  107. 107.
    Ljungberg, E., 1963, West Eur. Symp. Clin. Chem. 2:169–170.Google Scholar
  108. 108.
    DeLisi, L. E., Freed, W. J., Gillin, J. C., Kleinman, J. E., and Wyatt, R. J., 1982, Biol. Psychiatry 17:471–477.PubMedGoogle Scholar
  109. 109.
    Crow, T. J., Spear, P. J., and Arbuthnott, G. W., 1972, Brain Res. 36:275–287.PubMedCrossRefGoogle Scholar
  110. 110.
    Stein, L., and Wise, C. D., 1971, Science 171(3975): 1032–1036.PubMedCrossRefGoogle Scholar
  111. 111.
    Wise, C. D., and Stein, L., 1973, Science 181:344–347.PubMedCrossRefGoogle Scholar
  112. 112.
    Wise, C. D., Baden, M. M., and Stein, L., 1974, J. Psychiatr. Res. 11:185–198.PubMedCrossRefGoogle Scholar
  113. 113.
    Wyatt, R. J., Schwartz, M. D., Erdelyi, E., and Barchas, J. D., 1975, Science 187:368–369.PubMedCrossRefGoogle Scholar
  114. 114.
    Cross, A. J., Crow, T. J., Killpack, W. S., London, A., Owen, F., and Riley, G. L., 1978, Psychopharmacology 59:117–121.PubMedCrossRefGoogle Scholar
  115. 115.
    Creese, I., Burt, D. R., and Snyder, S. H., 1976, Science 192:481–483.PubMedCrossRefGoogle Scholar
  116. 116.
    Seeman, P., Lee, T., Chan-Wong, M., and Wong, K., 1976, Nature 261:717–719.PubMedCrossRefGoogle Scholar
  117. 117.
    Snyder, S. H., 1976, Am. J. Psychiatry 133:197–202.PubMedGoogle Scholar
  118. 118.
    Blumberg, J. B., Vetulani, J., Stawarz, R. J., and Sulser, F., 1976, Eur. J. Pharmacol. 37(2):357–366.PubMedCrossRefGoogle Scholar
  119. 119.
    Farley, I. J., Price, K. S., McCullough, E., Deck, J. H. N., Hordynski, W., and Hornykiewicz, O., 1978, Science 200:456–458.PubMedCrossRefGoogle Scholar
  120. 120.
    Crow, T. J., Owen, F., Cross, A. J., Lofthourse, R., and Longden, A., 1978, Lancet 1:36–37.Google Scholar
  121. 121.
    Bird, E. D., Spokes, E. G., and Iverson, L. L., 1979, Science 204:93–94.PubMedCrossRefGoogle Scholar
  122. 122.
    Carlsson, A., 1979, Catecholamines: Basic and Clinical Frontiers, Volume 1 (E. Usdin, I. J. Kopin, and J. D. Barchas, eds.), Pergamon Press, New York, pp. 4–19.Google Scholar
  123. 123.
    Gomes, V. C. R., Shanley, B. C., Potgieter, L., and Roux, J. T., 1980, Br. J. Psychiatry 137:346–351.PubMedCrossRefGoogle Scholar
  124. 124.
    Lake, C. R., Sternberg, D. E., van Kammen, D. P., Ballenger, J. C., Ziegler, M. G., Post, R. M., Kopin, I. J., and Bunney, W. E., 1980, Science 207:331–333.PubMedCrossRefGoogle Scholar
  125. 125.
    Kemali, D., Vecchio, M. D., and Maj, M., 1982, Biol. Psychiatry 17:711–717.PubMedGoogle Scholar
  126. 126.
    Kafka, M. S., van Kammen, D. B., Kleinman, J. E., Nurenberger, J. I., Siever, L. J., Uhde, T. W., and Polinsky, R. J., 1982, Commun. Psychopharmacol. 4(6):477–486.Google Scholar
  127. 127.
    Naber, D., Finkbeiner, C., Fischer, B., Zander, K. J., and Ackenheil, M., 1980, Neurop-sychobiology 6:181–189.CrossRefGoogle Scholar
  128. 128.
    Sternberg, D. E., van Kammen, D. P., Lake, C. R., Ballenger, J. C., Marder, S. R., and Bunney, W. E., 1981, Am. J. Psychiatry 138:1045–1050.PubMedGoogle Scholar
  129. 129.
    Freedman, R., Bell, J., and Kirch, D., 1980, Am. J. Psychiatry 137(5):629–630.PubMedGoogle Scholar
  130. 130.
    Ko, G., 1983, Abstr. Am. Psychiatr. Assoc.Google Scholar
  131. 131.
    Davis, J. M., Janicak, P., Chang, S., and Klerman, K., 1982, Psychiatry 1982: Annual Review, American Psychiatric Press, Washington, pp. 178–228.Google Scholar
  132. 132.
    Peet, M., Middlemiss, D. N., and Yates, R. A., 1980, Lancet 2(8201):978.PubMedCrossRefGoogle Scholar
  133. 133.
    Awapara, J., 1950, Fed. Proc. 9:148.Google Scholar
  134. 134.
    Roberts, E., and Frankel, S., 1950, Fed. Proc. 9:219.Google Scholar
  135. 135.
    Snyder, S. H., 1975, Biochem. Pharmacol. 24:1371–1374.CrossRefGoogle Scholar
  136. 136.
    Baxter, C., 1976, GABA in Nervous System Function (E. Roberts, T. N. Chase, and D. B. Tower, eds.), Raven Press, New York, pp. 61–87.Google Scholar
  137. 137.
    Yoshida, M., and Precht, W., 1971, Brain Res. 32:225–228.PubMedCrossRefGoogle Scholar
  138. 138.
    Fuxe, K., Perez de la Mora, M., Hokfelt, T., Agnati, L., Ljungdahl, A., and Johanson, O.,1977, Psychopathology and Brain Dysfunction (C. Shagass, S. Gershon, and A. J. Friedhoff, eds.), Raven Press, New York, pp. 97–111.Google Scholar
  139. 139.
    Roberts, E., 1972, Neurosci. Res. Prog. Bull. 10:468–483.Google Scholar
  140. 140.
    Cross, A. J., Crow, T. J., and Owen, F., 1979, Lancet 1:560–561.PubMedCrossRefGoogle Scholar
  141. 141.
    Bennett, J. P., Enna, S. J., Bylund, D. B., Gillin, J. C., Wyatt, R. J., and Synder, S. H., 1979, Arch. Gen. Psychiatry 36:927–934.PubMedCrossRefGoogle Scholar
  142. 142.
    Iversen, L. L., Bird, E., and Spokes, E., 1979, GABA-Neurotransmitters: Pharmacochem-ical, Biochemical and Pharmacological Aspects (P. Krogsgaard-Larsen, J. Scheel-Kruger, H. Kofod, eds.), Academic Press, New York, pp. 177–190.Google Scholar
  143. 143.
    Petty, T. L., Kish, S. J., Buchanan, J., and Hansen, S., 1979, Lancet 1:237.Google Scholar
  144. 144.
    Gold, B. I., Bowers, M. B., Jr., Roth, R. H., and Sweeney, D. W., 1980, Am. J. Psychiatry 137:362–364.PubMedGoogle Scholar
  145. 145.
    Lichtshtein, D., Dobkin, J., Ebstein, R. P., Biederman, J., Rimon, R., and Belmaker, R. H.,1978, Br. J. Psychiatry 132:145–148.PubMedCrossRefGoogle Scholar
  146. 146.
    van Kammen, D. P., Steinberg, D. E., Hare, T. A., Waters, R. N., Bunney, W. E., 1982, Arch. Gen. Psychiatry 39:91–97.PubMedCrossRefGoogle Scholar
  147. 147.
    McCarthy, B. W., Gomes, U. R., Neethling, A. C., Shanley, B. C., Talgaard, J. J., Potgieter, L., and Roux, S. T., 1981, J. Neurochem. 36(4): 1406–1408.PubMedCrossRefGoogle Scholar
  148. 148.
    Tamminga, C. A., Crayton, J. W., and Chase, T. N., 1978, Am. J. Psychiatry 135:746–747.PubMedGoogle Scholar
  149. 149.
    Schulz, S. C., van Kammen, D. P., Buchsbaum, M. S., Roth, R. H., Alexander, P., and Bunney, W. E., Jr., 1981, Pharmacopsychiatria 14:129–134.PubMedCrossRefGoogle Scholar
  150. 150.
    Simpson, G. M., Branchex, M. M., and Shrivastava, R. K., 1975, Lancet 1:966–967.Google Scholar
  151. 151.
    Tallman, J. F., Paul, S. M., Skolnick, P., and Gallager, D. W., 1980, Science 207:274–281.PubMedCrossRefGoogle Scholar
  152. 152.
    Jimerson, D. C., van Kammen, D. P., Post, R. M., Docherty, J. P., and Bunney, W. E., 1982, Am. J. Psychiatry 139:489–491.PubMedGoogle Scholar
  153. 153.
    Beckmann, H., and Haas, S., 1980, Psychopharmacology 71:79–82.PubMedCrossRefGoogle Scholar
  154. 154.
    Lingjaerde, O., 1982, Acta Psychiatr. Scand. 65:339–354.PubMedCrossRefGoogle Scholar
  155. 155.
    Wikler, A., 1952, Public Health Monograph No. 52, U. S. Dept. of Health, Education and Welfare, Washington.Google Scholar
  156. 156.
    Watson, S. J., Akil, H., Berger, P. A., and Barchas, J. D., 1979, Arch. Gen. Psychiatry 36:35–41.PubMedCrossRefGoogle Scholar
  157. 157.
    Berger, P. A., Watson, S. J., Akil, H., Elliot, G. R., Rubin, R. T., Pfefferbaum, A., Davis, K. L., Barchas, J. D., and Li, C. H., 1980, Arch. Gen. Psychiatry 37:635–640.PubMedCrossRefGoogle Scholar
  158. 158.
    Bloom, F., Segal, D., Ling, N., and Guillemin, R., 1976, Science 194:630.PubMedCrossRefGoogle Scholar
  159. 159.
    Jacquet, Y., and Marks, N., 1976, Science 194:632.PubMedCrossRefGoogle Scholar
  160. 160.
    Lindstrom, L. H., Widerlow, E., Gunne, L. M., Wahlstrom, A., and Terenius, L., 1978, Acta Psychiatr. Scand. 57:153–164.PubMedCrossRefGoogle Scholar
  161. 161.
    Domschke, W., Dickschas, A., and Mitznegg, P., 1979, Lancet 1:1024.PubMedCrossRefGoogle Scholar
  162. 162.
    Terenius, L., Wahlstrom, A., Lindstrom, L., and Widerlou, E., 1976, Neurosci. Lett. 3:157–162.PubMedCrossRefGoogle Scholar
  163. 163.
    Pickar, D., Cohen, M. R., Naber, D., and Cohen, R. M., 1982, Biol. Psychiatry 17:1243–1276.PubMedGoogle Scholar
  164. 164.
    Gunne, L. M., Lindstrom, L., and Terenius, L., 1977, J. Neural Transm. 40:13–19.PubMedCrossRefGoogle Scholar
  165. 165.
    Berger, P., Watson, S., Akil, H., and Barchas, J., 1981, Am. J. Psychiatry 138:913–915.PubMedGoogle Scholar
  166. 166.
    Lehman, H., Nair, N. P. V., and Kline, N. S., 1979, Am. J. Psychiatry 136:762–766.Google Scholar
  167. 167.
    Pickar, D., Vartanian, F., Bunney, W. E., Maier, H. P., Gastpar, M. T., Prakash, R., Sethi, B. B., Lideman, R., Belyaer, B. S., Tsutsulkovskaja, M. V. A., Jungkunz, G., Nedopil, N., Verhoeven, W., and van Praag, H., 1982, Arch. Gen. Psychiatry 39:313–319.PubMedCrossRefGoogle Scholar
  168. 168.
    Davis, G. L., and Bunney, W. E., Jr., 1980, Neural Peptides and Neuronal Communication (E. Costa and M. Trabucchi, eds.), Raven Press, New York, pp. 455–464.Google Scholar
  169. 169.
    Kline, N. S., Li, C. H., Lehmann, H. E., Lajtha, A., Laski, E., and Cooper, T., 1977, Arch. Gen. Psychiatry 34:1111–1113.PubMedCrossRefGoogle Scholar
  170. 170.
    Gerner, R. H., Catlin, D. H., Gorelick, D. A., Hui, K. K., and Li, C. H., 1980, Arch. Gen. Psychiatry 73:642–647.CrossRefGoogle Scholar
  171. 171.
    Pickar, D., Davis, G. C., Schulz, C., Exstein, I., Wagner, R., Naber, D., Gold, P. W., van Kammen, D. P., Goodwin, F. K., Wyatt, R. J., Li, C. H., and Bunney, W. E., 1981, Am. J. Psychiatry 138:160–166.PubMedGoogle Scholar
  172. 172.
    Verhoeven, W. M. A., van Praag, H. M., van Ree, J. M., and de Wied, D., 1979, Arch. Gen. Psychiatry 36:294–298.PubMedCrossRefGoogle Scholar
  173. 173.
    Meltzer, H. Y., Busch, D. A., Tricou, B. J., and Robertson, A., 1982, Psychiatr. Res. 6(3):313–326.CrossRefGoogle Scholar
  174. 174.
    Tamminga, C. A., Tighe, P. J., Chase, T. N., De Fraites, E. G., and Shaffer, M. H., 1981, Arch. Gen. Psychiatry 38:167–174.PubMedCrossRefGoogle Scholar
  175. 175.
    Jorgenson, A., Fog, R., and Veilisi, B., 1979, Lancet 1:935.CrossRefGoogle Scholar
  176. 176.
    Hökfelt, T., Skirboll, L., Rehfeld, J. F., Goldstein, M., Markey, K., and Dann, O., 1980, Neuroscience 5(12):2093–2124.PubMedCrossRefGoogle Scholar
  177. 177.
    Crow, T. J., 1982, Abstracts of the Annual meeting of the American College of Psycho-pharmacology, ACNP, Inc., Vanderbilt University, Nashville, p. 28.Google Scholar
  178. 178.
    Kleinman, J. E., Hong, J., Gellin, J. C., Govoni, S., and Wyatt, R. J., 1982, Abstract of the Annual Meeting of the American College of Neuropsychopharmacology, p. 28.Google Scholar
  179. 179.
    Nair, N. P., Bloom, D. M., and Nestoros, J. N., 1982, Prog. Neuropsychopharmacol. Biol. Psychiatry 6:509–512.PubMedCrossRefGoogle Scholar
  180. 180.
    Morogi, T., Watanabe, N., Aoki, N., and Itoh, S., 1982, Arch. Gen. Psychiatry 39:485–486.CrossRefGoogle Scholar
  181. 181.
    Osmond, H., and Smythies, J., 1952, J. Ment. Sci. 98:309–315.PubMedGoogle Scholar
  182. 182.
    Kety, S. S., 1967, Amines and Schizophrenia (H. E. Himwich, S. S. Kety, and J. R. Smythies, eds.), Pergamon Press, Oxford, pp. 271–277.Google Scholar
  183. 183.
    Wyatt, R. J., Termini, B. A., and Davis, J., 1971, Schizophren. Bull 4:10–44.CrossRefGoogle Scholar
  184. 184.
    Pollin, W., Cardon, P. V., Jr., and Kety, S. S., 1961, Science 133:104–105.PubMedCrossRefGoogle Scholar
  185. 185.
    Brune, G. C., and Himwvich, H. E., 1962, J. Nerv. Ment. Dis. 137:447–450.CrossRefGoogle Scholar
  186. 186.
    Alexander, F., Curtis, G. C., Sprince, H., and Crosley, A. P. J., 1963, J. Nerv. Ment. Dis. 137:135–142.PubMedCrossRefGoogle Scholar
  187. 187.
    Antun, F. T., Burnett, G. B., Cooper, A. J., Daly, R. J., Smythies, J. R., and Zealley, A. K., 1971, J. Psychiatr. Res. 8:63–71.PubMedCrossRefGoogle Scholar
  188. 188.
    Antun, F. T., and Kurkjian, R., 1982, Br. J. Psychiatry 140:611–614.PubMedCrossRefGoogle Scholar
  189. 189.
    Pscheidt, G. R., Beriet, H. H., Spaide, J., and Himwich, H. E., 1961, Clin. Chim. Acta 13:229–334.Google Scholar
  190. 190.
    Kline, M. S., 1967, Br. J. Psychiatry 113:731–742.PubMedCrossRefGoogle Scholar
  191. 191.
    Meltzer, H., Shader, R., and Grinspoon, L., 1969, Psychopharmacologia 15:144–152.PubMedCrossRefGoogle Scholar
  192. 192.
    Friedhoff, A. J., and Van Winkle, E., 1962, Nature 194:897–898.CrossRefGoogle Scholar
  193. 193.
    Szara, S., 1956, Experientia 12:441–442.PubMedCrossRefGoogle Scholar
  194. 194.
    Franzen, F., and Gross, H., 1965, Nature 206:1052.PubMedCrossRefGoogle Scholar
  195. 195.
    Checkley, S. A., Murray, R. M., Oon, M. C. H., Rodnight, R., and Birley, J. L. T., 1980, Br. J. Psychiatry 137:236–239.PubMedCrossRefGoogle Scholar
  196. 196.
    Gillin, J. C., Kaplan, J., Stillman, R., and Wyatt, R. J., 1976, Am. J. Psychiatry 133:203–208.PubMedGoogle Scholar
  197. 197.
    Wyatt, R. J., Saavedra, J. M., and Axelrod, J., 1973, Am. J. Psychiatry 130:754–760.PubMedGoogle Scholar
  198. 198.
    Mandel, L. R., Ahn, H. S., and Vandenheuvel, W. J., 1972, Biochem. Pharmacol. 21:1197–1200.PubMedCrossRefGoogle Scholar
  199. 199.
    Mandel, L. R., Prasad, R., Lopez-Ramos, B., and Walker, R. W., 1977, Res. Commun. Chem. Pathol. Pharmacol. 16:47–58.PubMedGoogle Scholar
  200. 200.
    Walker, R. W., Mandel, L. R., DeLisi, L. E., Wyatt, R. J., and Vandenheuvel, W. J. A., 1983, Abstracts of the International Symposium on Advances in Chromatography, Amsterdam.Google Scholar
  201. 201.
    Frohman, C. E., Latham, K. L., Beckett, P. G. S., and Gottlieb, J. S., 1960, Arch. Gen. Psychiatry 2:255–262.CrossRefGoogle Scholar
  202. 202.
    Frohman, C. E., Harmison, C. R., Arthur, R. E., and Gottlieb, J. S., 1971, Biol. Psychiatry 3:113–121.PubMedGoogle Scholar
  203. 203.
    Frohman, C. E., Arthur, R. E., and Gottlieb, J. S., 1973, Biol. Psychiatry 7:53–61.PubMedGoogle Scholar
  204. 204.
    Sandler, M., and Reynolds, G. P., 1976, Lancet 1:70–71.PubMedCrossRefGoogle Scholar
  205. 205.
    Wyatt, R. J., Gillin, J. C., Stoff, D. M., Moja, E. A., and Tinklenberg, J. H., 1977, Neu-roregulators and Psychiatric Disorders (E. Usdin, J. Barchas, and D. Hamburg, eds.), Oxford University Press, New York, pp. 31–45.Google Scholar
  206. 206.
    Moja, E. A., Stoff, D. M., Gillin, J. C., and Wyatt, R. J., 1978, Biol. Psychiatry 13:291–295.PubMedGoogle Scholar
  207. 207.
    Fischer, E., Spatz, H., Saavedra, J. M., Reggiani, H., Mira, A., and Heller, B., 1972, Biol. Psychiatry 5:139–147.PubMedGoogle Scholar
  208. 208.
    Fischer, E., Heller, B., and Miro, A. H., 1968, Arzneim. Forsch. 18:1486.Google Scholar
  209. 209.
    Potkin, S., Karoum, F., Chuang, L. W., Cannon-Spoor, E., Philips, I., and Wyatt, R. J., 1979, Science 206:470–471.PubMedCrossRefGoogle Scholar
  210. 210.
    Jeste, D. V., Doongaji, D. R., Panjwani, D., Datta, M., Potkin, S. G., Karoum, F., Thatle, S., Sheth, A. S., Apte, J. S., and Wyatt, R. J., 1981, Psychiatr. Res. 5:341–352.CrossRefGoogle Scholar
  211. 211.
    Paulos, M. A., and Tessel, R. E., 1982, Science 215:1127–1129.PubMedCrossRefGoogle Scholar
  212. 212.
    Karoum, F., Linnoila, M., Potter, W. Z., Chuang, L. W., Goodwin, F. K., and Wyatt, R. J., 1982, Psychiatry Res. 6:215–222.PubMedCrossRefGoogle Scholar
  213. 213.
    DeLisi, L. E., Murphy, D., Karoum, F., Targum, S., and Wyatt, R. J., 1984, Psychiatry Res. (in press).Google Scholar
  214. 214.
    Sabelli, H. C., and Borison, R. L., 1976, Advances in Biochemical Psychopharmacology, Volume 15 (E. Costa, E. Ciacobini, and R. Paoletti, eds.), Raven Press, New York, pp. 75–86.Google Scholar
  215. 215.
    Linnoila, M., Potter, W., Potkin, S. G., and Wyatt, R. J., 1984, Br. J. Psychiatry 144:428–431.PubMedCrossRefGoogle Scholar
  216. 216.
    Heath, R. G., Martens, S., Leach, B. E., Cohen, M., and Angel, C., 1957, Am. J. Psychiatry 114:14–24.PubMedGoogle Scholar
  217. 217.
    Heath, R. G., Guschwan, A. F., and Coffey, J. W., 1970, Dis. Nerv. Syst. 31:391–395.PubMedGoogle Scholar
  218. 218.
    Heath, R. G., and Krupp, I. M., 1967, Arch. Gen. Psychiatry 16:1–9.PubMedCrossRefGoogle Scholar
  219. 219.
    Robins, E., 1957, Neuropharmacology (H. S. Abramson, ed.), Josiah Macy, Jr., Foundation, New York, p. 123.Google Scholar
  220. 220.
    Siegal, M., Niswander, C. D., Sachs, E., Jr., and Stavros, D., 1959, Am. J. Psychiatry 115:819.Google Scholar
  221. 221.
    Bergen, J. R., Grinspoon, L., Pyle, H. M., Martinez, J. L., and Pennell, R. B., 1980, Biol. Psychiatry 15:369–379.PubMedGoogle Scholar
  222. 222.
    Martens, S., Vallbo, S., and Melander, B., 1959, Acta Psychiat. Neurol. Scand. Suppl. 136:361.CrossRefGoogle Scholar
  223. 223.
    Meckler L. B., Lapteva, N. N., Lozovskii, D. V., and Balezinc, T. I., 1960, Proc. Acad. Sci. SSSR 130:1148.Google Scholar
  224. 224.
    Nelson, J. W., Daniels, E. G., Mann, K. M., and Kinman, J. W., 1963, Serological Fractions in Schizophrenia (R. G. Heath, ed.), Hoeber Medical Division, Harper and Row, New York, pp. 43–56.Google Scholar
  225. 225.
    Boehme, D. H., Cottrell, J. C., Dohan, F. C., and Hillegass, L. M., 1974, Biol. Psychiatry 8(1):89–94.PubMedGoogle Scholar
  226. 226.
    Hirata-Hibi, M., Higashi, S., Tachibana, T., and Watanabe, N., Arch. Gen. Psychiatry 39:82–87.Google Scholar
  227. 227.
    Vartanian, M. E., Koliaskina, G. I., Lozovsky, D. V., Burbaeva, G. S., and Ignator, S. A., 1978, Birth Defects 14:339–364.PubMedGoogle Scholar
  228. 228.
    Liedeman, R. R., and Prilipko, L. L., 1978, Birth Defects 14:365–377.PubMedGoogle Scholar
  229. 229.
    Zarrabi, M. H., Zucker, S., Miller, F., Derman, R. M., Romeno, G. S., Hartnett, J. A., and Varma, A. O., 1979, Ann. Intern. Med. 91:194–199.PubMedGoogle Scholar
  230. 230.
    DeLisi, L. E., Goodman, S., Neckers, L. M., and Wyatt, R. J., 1982, Biol. Psychiatry 17(9):1003–1007.PubMedGoogle Scholar
  231. 231.
    Coffey, C. E., Sullivan, J. L., and Rice, J. R., 1983, Biol. Psychiatry 18:113–119.PubMedGoogle Scholar
  232. 232.
    McGuffin, P., 1979, Psychol. Med. 9:721–728.PubMedCrossRefGoogle Scholar
  233. 233.
    McGuffin, P., Farmer, A. E., and Yonace, A. H., 1981, Psychol. Res. 5:115–122.Google Scholar
  234. 234.
    Luchins, D. J., Weinberger, D. R., Zalcman, S., DeLisi, L. E., Rogentine, N., and Wyatt, R. J., 1980, Br. J. Psychiatry 136:243–248.PubMedCrossRefGoogle Scholar
  235. 235.
    Smeraldi, E., Sacchetti, E., and Cazzullo, C. L., 1976, Br. J. Psychiatry 129:486–489.PubMedCrossRefGoogle Scholar
  236. 236.
    APA Task Force Report 7, 1973, Megavitamin and Orthomolecular Therapy in Psychiatry, American Psychiatric Association, Washington, D.C.Google Scholar
  237. 237.
    Wyatt, R. J., 1974, Am. J. Psychiatry 131:1258–1261.Google Scholar
  238. 238.
    Pauling, L., 1974, Am. J. Psychiatry 131:1251–1257.PubMedGoogle Scholar
  239. 239.
    Herjanic, M., 1973, Orthomolecular Psychiatry: Treatment of Schizophrenia (D. Hawkins and L. Pauling, eds.), W. H. Freeman, San Francisco, pp. 303–315.Google Scholar
  240. 240.
    Milner, G., 1963, Br. J. Psychiatry 109:294–299.CrossRefGoogle Scholar
  241. 241.
    Kraepelin, E., 1910, Geschlachtliche Verirrungen und Volksvermehrungpsychiatric, edition 8, J. Barth, Leipzig.Google Scholar
  242. 242.
    Lewis, N. D. C., and Davies, G. R., 1921, J. Nerv. Ment. Dis. 54:385–493.CrossRefGoogle Scholar
  243. 243.
    Mott, F. W., 1922, Br. Med. J. 1:463–467.PubMedCrossRefGoogle Scholar
  244. 244.
    Morse, M. E., 1923, J. Neurol. Psychopathol. 4:1–26.PubMedCrossRefGoogle Scholar
  245. 245.
    Geller, F. C., 1923 Arch. Gynakol. 120:237–248.CrossRefGoogle Scholar
  246. 246.
    Rey, J. H., and Coppen, A. J., 1959, Br. Med. J. 11:1445–1447.CrossRefGoogle Scholar
  247. 247.
    Richter, D., 1970, Biol. Psychiatry 2:153–164.PubMedGoogle Scholar
  248. 248.
    Hoskins, R. G., 1943, Psychosom. Med. 5:3–9.Google Scholar
  249. 249.
    Hemphill, R. E., and Reiss, M., 1945, J. Ment. Sci. 91:1–7.Google Scholar
  250. 250.
    Shader, R. I., Taymoor, M. I., and Grinspoon, L., 1968, Proceedings IV World Congress of Psychiatry, pp. 2988–2991.Google Scholar
  251. 251.
    Johnstone, E. C., Crow, T. J., and Mashiter, K., 1977, Psychol. Med. 7:223–228.PubMedCrossRefGoogle Scholar
  252. 252.
    Ferrier, I. N., 1982, Biological Aspects of Schizophrenia and Addiction, (G. Hemmings, ed.), John Wiley and Sons, New York, pp. 35–47.Google Scholar
  253. 253.
    Horrobin, D. F., 1977, Lancet 1:936–937.PubMedCrossRefGoogle Scholar
  254. 254.
    Feldberg, W., 1976, Psychol. Med. 6:359–369.PubMedCrossRefGoogle Scholar
  255. 255.
    Price, E. J., and Rowe, C. E., 1972, Biochem. J. 126:575.PubMedGoogle Scholar
  256. 256.
    Mathe, A. A., Sedvall, C., Wiesel, F. A., and Nyback, H., 1980, Lancet 1:16–17.PubMedCrossRefGoogle Scholar
  257. 257.
    Wolfe, L. S., and Coceani, F., 1979, Annu. Rev. Physiol. 41:669–684.PubMedCrossRefGoogle Scholar
  258. 258.
    Lycke, E., and Roos, B. E., 1968, Experientia 24:687–689.PubMedCrossRefGoogle Scholar
  259. 259.
    Lycke, E., and Roos, B. E., 1974, J. Neurol. Sci. 22:277–289.PubMedCrossRefGoogle Scholar
  260. 260.
    Rosenthal, D., Wender, P. H., Kety, S. S., Schulsinger, F., Welner, J., and Oskergaard, J., The Transmission of Schizophrenia (D. Rosenthal and S. S. Kety, eds.), Pergamon Press, New York.Google Scholar
  261. 261.
    Slater, E., 1968, The Transmission of Schizophrenia (D. Rosenthal and S. S. Kety eds.), Pergamon Press, New York.Google Scholar
  262. 262.
    Kety, S. S., Rosenthal, D., Wender, P. H., Schulsinger, F., and Jacobsen, B., 1975, Genetic Research in Psychiatry (R. R. Fieve, D. Rosenthal, and H. Brill, eds.), Johns Hopkins University Press, Baltimore.Google Scholar
  263. 263.
    Cancro, R., 1982, Psychiatry 1982: The American Psychiatric Association Annual Review (L. Grinspoon, ed.), American Psychiatric Press, Washington, pp. 92–96.Google Scholar
  264. 264.
    Gottesman, I. I., and Shields, J., 1976, Schizophren. Bull. 2:360–401.CrossRefGoogle Scholar
  265. 265.
    Lidz, T., Schafer, S., Fleck, S., Cornelison, A., and Terry, D., 1962, J. Am. Psychoanal. Assoc. 10:74–90.PubMedCrossRefGoogle Scholar
  266. 266.
    Jackson, D. D., 1959, The Study of Schizophrenia (D. D. Jackson, ed.), Basic Books, New York, pp. 37–90.Google Scholar
  267. 267.
    Allen, M. G., Cohen, S., and Pollin, W., 1971, Am. J. Psychiatry 128:939–945.Google Scholar
  268. 268.
    Elston, R. C., and Cambell, M. A., 1970, Behav. Genet. 1:3–10.PubMedCrossRefGoogle Scholar
  269. 269.
    Tsuang, M. T., Bucher, K. D., and Fleming, J. A., 1982, Br. J. Psychiatry 140:595–599.PubMedCrossRefGoogle Scholar
  270. 270.
    DeLisi, L. E., Wise, C. D., Bridge, T. P., Potkin, S., Phelps, B., and Wyatt, R. J., 1981, Biological Markers for Mental Illness, Pergammon Press, New York, pp. 79–96.Google Scholar
  271. 271.
    Weinshilboum, R. M., Raymond, F. A., Elveback, L. R., and Weidman, W. H., 1973, Science 181:943.PubMedCrossRefGoogle Scholar
  272. 272.
    Ross, S. B., Book, J. A., and Wetterberg, L., 1981, Clin. Genet. 19(5):415–426.PubMedCrossRefGoogle Scholar
  273. 273.
    Fujita, D., Ito, T., Maruta, K., Teradaera, R., Beppu, H., Nakagama, Y., Kato, Y., Nagatsu, T., and Kato, T., 1978, J. Neurochem. 30:1569–1572.PubMedCrossRefGoogle Scholar
  274. 274.
    Böök, J. A., Wetterberg, L., and Modrzewska, S., 1978, Clin. Genet. 14(6):373–394.PubMedCrossRefGoogle Scholar
  275. 275.
    DeLisi, L. E., Wise, C. D., Phelps, B. H., Zalcman, S., Potkin, S. G., and Wyatt, R. J., 1980, Biol. Psychiatry 15(6):899–905.Google Scholar
  276. 276.
    Markianos, E. S., Nystrom, I., Reichel, H., and Matussek, N., 1976, Psychopharmacology 50:259–267.PubMedCrossRefGoogle Scholar
  277. 277.
    Sternberg, D. E., van Kammen, D. P., Lerner, P., and Bunney, W. E., 1980 Abstracts of the Annual Meeting of the Society of Biological Psychiatry, San Francisco.Google Scholar
  278. 278.
    van Kammen, D. P., Mann, L., Sternberg, D. E., Scheinan, M., Ninan, P., Marder, S. R., van Kammen, W. B., Reider, R., and Linnoila, M., 1983, Science 220:974–977.PubMedCrossRefGoogle Scholar
  279. 279.
    DeLisi, L. E., Phelps, B., Wise, C. D., Apostoles, P. S., and Wyatt, R. J., 1981, Biol. Psychiatry 16:873–878.PubMedGoogle Scholar
  280. 280.
    Jeste, D. V., DeLisi, L. E., Zalcman, S., Wise, C. D., Phelps, B. H., Rosenblatt, J. E., Potkin, S. G., Bridge, T. P., and Wyatt, R. J., 1981, Psychiatry Res. 4:327–332.PubMedCrossRefGoogle Scholar
  281. 281.
    Viukari, M., and Linnoila, M., 1977, Acta. Psychiatr. Scand. 56:57–61.PubMedCrossRefGoogle Scholar
  282. 282.
    Birket-Smith, E., and Anderson, J. V., 1973, Lancet 1:431.PubMedCrossRefGoogle Scholar
  283. 283.
    Menninger, K. A., 1925, Assoc. Res. Nerv. Ment. Dis. Proc. 5:182–203.Google Scholar
  284. 284.
    Petrov, P. A., 1970, Am. J. Trop. Med. Hyg. 19:146–150.PubMedGoogle Scholar
  285. 285.
    Torrey, E. F., 1980, Civilization and Schizophrenia, Jason Aronson, New York.Google Scholar
  286. 286.
    Torrey, E. F., Torrey, B., and Peterson, M., 1977, Arch. Gen. Psychiatry 34:1065–1070.PubMedCrossRefGoogle Scholar
  287. 287.
    Hare, E. H., and Walter, S. D., 1978, J. Epidemiol. Commun. Health 32:47–52.CrossRefGoogle Scholar
  288. 288.
    Abe, K., 1969, Br. J. Psychiatry 115:519–531.PubMedCrossRefGoogle Scholar
  289. 289.
    Crow, T. J., 1983, Lancet 1:173–175.PubMedCrossRefGoogle Scholar
  290. 290.
    Strahilevitz, M., Fleishman, J., Fischer, G., Harris, R., and Narasimhachari, N., 1976, Am. J. Psychiatry 133:.772–777.PubMedGoogle Scholar
  291. 291.
    Torrey, E. F., Peterson, M. R., Brannon, W. L., Carpenter, W. T., Post, R. M., and van Kammen, D. P., 1978, Br. J. Psychiatry 132:342–348.CrossRefGoogle Scholar
  292. 292.
    Gowdy, J. M., 1980, Psycho somatic s 21:751–756.Google Scholar
  293. 293.
    DeLisi, L. E., Weinberger, D. R., Neckers, L. M., Potkin, S. G., Shiling, D., and Wyatt, R. J., 1981, Br. J. Psychiatry 139:513–519.PubMedCrossRefGoogle Scholar
  294. 294.
    Amkraut, A., Solomon, G. F., Allansmith, M., McClellan, B., and Rappaport, M., 1973, Arch. Gen. Psychiatry 28:673–677.PubMedCrossRefGoogle Scholar
  295. 295.
    Johnstone, E. C., and Whaley, K., 1975, Br. Med. J. 2:724–725.PubMedCrossRefGoogle Scholar
  296. 296.
    Koliaskina, G., Tsutsulkovskaya, M., Domashneva, L, Maznina, T., Kielholz, P., Gastpar, M., Bunney, W., Rafaelson, O., Heltberg, J., Coppen, A., Hippius, H., Hoechesl, B., and Vartanian, F., 1980, Neuropsychobiology 6:349–355.PubMedCrossRefGoogle Scholar
  297. 297.
    Watanabe, M., Funahashi, T., Suzuki, T., Nomura, S., Nakazawa, T., Noguchi, T., and Tsukada, Y., 1982, Biol. Psychiatry 17(6):699–710.PubMedGoogle Scholar
  298. 298.
    Halonen, P., Rimon, R., Arochonka, R., and Jantti, V., 1974, Br. J. Psychiatry 125:461–465.PubMedCrossRefGoogle Scholar
  299. 299.
    Rimon, R., Halonen, P., Pukakka, P., Laitinen, L., Marttila, R., and Salmela, L., 1979, J. Clin. Psychiatry 40:241–243.PubMedGoogle Scholar
  300. 300.
    Albrecht, P., Torrey, E. F., Boone, E., Hicks, J., and Daniel, N., 1980, Lancet 2:769–772.PubMedCrossRefGoogle Scholar
  301. 301.
    Torrey, E. F., Yolken, R. H., Winfrey, C. J., 1982, Science 216:892–894.PubMedCrossRefGoogle Scholar
  302. 302.
    Tyrrell, D. A. J., Parry, R. P., Crow, T. J., Johnstone, E., and Ferrier, I. N., 1979, Lancet 1:839–841.PubMedCrossRefGoogle Scholar
  303. 303.
    Taylor, G. R., Crow, T. J., Ferrier, I. N., Johnstone, E. C., Parry, R. P., and Tyrrell, D. A. J., 1982, Lancet 2:1166–1167.PubMedCrossRefGoogle Scholar
  304. 304.
    Sequiera, L. W., Carrasco, L. H., Curry, A., Jennings, L. C., Lord, M. A., and Sutton, R. N. P., 1979, Lancet 2:609–612.PubMedCrossRefGoogle Scholar
  305. 305.
    Johnson, R. T., 1982, Viral Infections of the Nervous System, Raven Press, New York.Google Scholar
  306. 306.
    Nyberg, P., Almay, B. G. L., Carlsson, A., Masters, C., and Winblad, B., 1982, Acta Neurol. Scand. 66:16–24.PubMedCrossRefGoogle Scholar
  307. 307.
    Hughes, J. J., and Little, J. C., 1967, Br. J. Psychiatry 113:867–873.PubMedCrossRefGoogle Scholar
  308. 308.
    Letemendia, F. J. J., and Harris, A. D., 1967, Br. J. Psychiatry 113:950–958.PubMedCrossRefGoogle Scholar
  309. 309.
    Baker, H. F., Bloxham, C., Crow, T. J., Davies, H., Ferrier, I. N., Johnstone, E. C., Parry, R. P., Ridley, R. M., Taylor, G. R., Tyrrell, D. A. J., 1983, Adv. Biol. Psychiat. 12:1–19.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Lynn Eleanor DeLisi
    • 1
  • Richard Jed Wyatt
    • 2
  1. 1.Neurogenetics Branch, Intramural Research ProgramNational Institute of Mental HealthBethesdaUSA
  2. 2.Neuropsychiatry Branch, Intramural Research Program, National Institute of Mental HealthSaint Elizabeths HospitalUSA

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