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Analysis of Biclonal Immunoglobulins and Their Contributions to Understanding the Developmental Aspects of the Antibody Response

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Book cover Contemporary Topics in Molecular Immunology

Part of the book series: Contemporary Topics in Molecular Immunology ((CTI))

Abstract

Biclonal gammopathy is defined as the syndrome in which the serum of a given individual contains abnormally large amounts of two distinct, homogeneous populations of immunoglobulins. Other terms used to describe this state are biclonal myeloma, double myeloma, and oligoclonal gammopathy. Biclonal gammopathy is associated not only with multiple myeloma; it has been observed in individuals with other types of malignant and nonmalignant diseases as well as in individuals with apparently benign conditions. In contrast, monoclonal gammopathy is an increase in a serum immunoglobulin that has the elctrophoretic mobility of a monoclonal protein and is often a manifestation of the neo-plastic process associated with multiple myeloma or Waldenström’s macroglobulinemia. This immunoglobulin is usually a chemically homogeneous product secreted by a clone of neoplastic lymphocytes or plasma cells. The protein is monoclonal because it comprises one type of heavy chain (i.e., α,γ, μ, δ, or ∈) and one type of light chain (k or λ).

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Authors and Affiliations

  1. Department of Molecular Immunology, Research Institute of Scripps Clinic, La Jolla, California, 92037, USA

    Daryl S. Fair

  2. The Christ Hospital Institute of Medical Research, 2141 Auburn Avenue, Cincinnati, Ohio, 45219, USA

    Robert G. Krueger

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Editors and Affiliations

  1. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, California, USA

    Ralph A. Reisfeld

  2. Department of Biochemistry, East Tennessee State University, Johnson City, Tennessee, USA

    F. P. Inman

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Fair, D.S., Krueger, R.G. (1978). Analysis of Biclonal Immunoglobulins and Their Contributions to Understanding the Developmental Aspects of the Antibody Response. In: Reisfeld, R.A., Inman, F.P. (eds) Contemporary Topics in Molecular Immunology. Contemporary Topics in Molecular Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0779-3_2

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