• Marc A. Schuckit
Part of the Critical Issues in Psychiatry book series (CIPS)


Marijuana is among the most widely used of the drugs described in this text. The health-care problems involved with delta-9-tetrahydrocannabinol (THC) (the most active ingredient in marijuana and hashish), include panic reactions, toxic reactions, and a great deal of anxiety in the general population about possible mental and physiological damage to young users. Because you will be called on, as a healthcare deliverer, to give information about this drug to worried parents and to teenagers attempting to make decisions about future use, this chapter presents information on the history, the physiology, and the medical effects of the cannabinols.


Toxic Reaction Heavy User Major Psychiatric Disorder Marijuana User Organic Brain Syndrome 
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  1. 1.
    Weller, R. A., und Halikas, J. A. Objective criteria for the diagnosis of marijuana abuse. Journal of Nervous and Mental Disease 168: 98–103, 1980.CrossRefGoogle Scholar
  2. 2.
    Jaffe, J. H. Drug addiction and drug abuse. In A. G. Gilman, L. S. Goodman, und A. Gilman (Eds.), The Pharmacological Basis of Therapeutics ( 7th ed. ). New York: Macmillan, 1985, pp. 558–561.Google Scholar
  3. 3.
    Liskow, B. Marijuana deterioration. Journal of the American Medical Association 214:1709, 1970.Google Scholar
  4. 4.
    Talbott, J. A. The emergency management of marijuana psychosis. In P. G. Bourne (Ed.), A Treatment Manual for Acute Drug Abuse Emergencies. Washington, D.C.: U.S. Govemment Printing Office, 1974, pp. 83–87.Google Scholar
  5. 5.
    Domino, L. E., Domino, S. E., und Domino, E. F. Do plasma levels of delta-9-tetrahydrocannabinol reflect a marijuana high? Psychopharmacology Bulletin 19: 760–765, 1983.Google Scholar
  6. 6.
    Sallan, S. E. Antiemetics in patients receiving chemotherapy for cancer. New England Journal of Medicine 302: 135–138, 1980.PubMedCrossRefGoogle Scholar
  7. 7.
    Harris, L. S. Cannabinoids as analgesics. In R. F. Beers und T. Basset (Eds.), Pain and Analgesic Compounds. New York: Raven Press, 1979, pp. 467–473.Google Scholar
  8. 8.
    Nahas, G. Biomedical aspects of cannabis usage. Bulletin on Narcotics 24: 13–27, 1977.Google Scholar
  9. 9.
    Dackis, C. A., Pottash, A. L. C., Annito, W., Persistence of urinary marijuana levels after supervised abstinence. American Journal of Psychiatry 139:1196–1198, 1982.Google Scholar
  10. 10.
    Sethi, B. G. B., Trivedi, J. K., Kumar, P., et al. Antianxiety effect of cannabis: Involvement of central benzodiazepine receptors. Biological Psychiatry 21: 3–10, 1986.PubMedCrossRefGoogle Scholar
  11. 11.
    Stillman, R., Galanter, M., und Lemberger, L. Tetrahydrocannabinol (THC): Metabolism and subjective effects. Life Sciences 19: 569–576, 1976.PubMedCrossRefGoogle Scholar
  12. 12.
    Mendelson, J. H., Rossi, A. M., und Meyer, R. E. The Use of Marihuana: A Psychological and Physiological Inquiry. New York: Plenum Press, 1974.Google Scholar
  13. 13.
    Galanter, M., Stillman, R., Wyatt, R. J., Marihuana and social behavior: A controlled study. Archives of General Psychiatry 30: 518–521, 1974.PubMedCrossRefGoogle Scholar
  14. 14.
    Weil, A. T., Zinberg, N. E., und Nelsen, J. M. Clinical and psychological effects of marihuana in man. Science 162:1234–1242, 1968.Google Scholar
  15. 15.
    Weil, A. T. Adverse reactions to marihuana: Classification and suggested treatment. New England Journal of Medicine 282: 997–1000, 1970.PubMedCrossRefGoogle Scholar
  16. 16.
    Feeney, D. M. Marihuana and epilepsy. Science 197: 1301–1302, 1977.PubMedGoogle Scholar
  17. 17.
    Nicholi, A. M. The nontherapeutic use of psychoactive drugs. New England Journal of Medicine 308: 925–933, 1983.PubMedCrossRefGoogle Scholar
  18. 18.
    Cohen, S., Sc Stillman, R. C. The Therapeutic Potential of Marihuana. New York: Plenum Press, 1976.Google Scholar
  19. 19.
    Gottschalk, L. A. Aronow, W. S., und Prakash, R. Effect of marijuana and placebo-marijuana smoking on psychological state and on psychophysiological cardiovascular functioning in anginal patients. Biological Psychiatry 12: 255–266, 1977.PubMedGoogle Scholar
  20. 20.
    Jones, R. T. Clinical relevance of cannabis tolerance and dependence. Journal of Clinical Pharmacology 211: 1435–1475, 1981.Google Scholar
  21. 21.
    Perez-Reyes, M., Hicks, R., Bumberry, J., Jeffcoat, A. R., und Coak, C. E. Interaction between marijuana and alcohol. Alcoholism: Clinical and Experimental Research 12: 268–272, 1988.CrossRefGoogle Scholar
  22. 22.
    Kaymakcalan, S. Potential dangers of cannabis. International Journal of the Addictions 10: 72 1735, 1975.Google Scholar
  23. 23.
    Smart, R. G., und Murray, G. F. A review of trends in alcohol and cannabis use among young people. Bulletin on Narcotics 33: 77–90, 1981.PubMedGoogle Scholar
  24. 24.
    Wechsler, H., und Rohman, M. E. Patterns of drug use among New England college students. American Journal of Drug and Alcohol Abuse 8: 27–37, 1981.PubMedCrossRefGoogle Scholar
  25. 25.
    Reiman, A. S. Marijuana “justifies serious concern.” In Marijuana and Health Washington, D.C.: National Academy Press, 1982.Google Scholar
  26. 26.
    Kozel, N. J., und Adams, E. H. Epidemiology of drug abuse: An overview. Science 234: 970–974, 1986.PubMedCrossRefGoogle Scholar
  27. 27.
    Smart, R. G., Adlaf, E. M., und Goodstadt, M. S. Alcohol and other drug use among Ontario students: An update. Canadian Journal of Public Health 77: 57–58, 1986.Google Scholar
  28. 28.
    Smart, R. G., Goodstadt, M. S., Adlaf, E. M., Trends in the prevalence of alcohol and other drug use among Ontario students: 1977–1983. Canadian Journal of Public Health 76: 157–161, 1985.Google Scholar
  29. 29.
    Editorial: National survey finds continuing decline in use of illicit drugs by high school seniors. Hospital and Community Psychiatry 36: 1011–1012, 1985.Google Scholar
  30. 30.
    Editorial: Epidemiology of drug usage. Lancet 1: 147, 1985.Google Scholar
  31. 31.
    Kandel, D. B. Marijuana users in young adulthood. Archives of General Psychiatry 41: 200–209, 1984.PubMedCrossRefGoogle Scholar
  32. 32.
    Lex, B. W., Griffin, M. L., Mello, N. K., und Mendelson, J. H. Concordant alcohol and marihuana use in women. Alcohol 3: 193–200, 1986.PubMedCrossRefGoogle Scholar
  33. 33.
    Kandel, D. B., Davies, M., Karus, D., und Yamaguchi, K. The consequences in young adulthood of adolescent drug involvement. Archives of General Psychiatry 43: 746–754, 1986.PubMedCrossRefGoogle Scholar
  34. 34.
    Rose, M. Cannabis: A medical question? Lancet 1: 703, 1980.PubMedGoogle Scholar
  35. 35.
    Halikas, J. A., Goodwin, D. W., und Guze, S. B. Marihuana use and psychiatric illness. Archives of General Psychiatry 27:162–165, 1972.Google Scholar
  36. 36.
    Treffert, D. A. Marihuana use in schizophrenia: A clear hazard. Paper presented at the 130th Annual Meeting of the American Psychiatric Association, Toronto, Ontario, Canada, May 5, 1977.Google Scholar
  37. 37.
    Edwards, G. Psychopathology of a drug experience. British Journal of Psychiatry 143: 509–512, 1983.PubMedCrossRefGoogle Scholar
  38. 38.
    Smart, R. G., und Adlaf, E. M. Adverse reactions and seeking medical treatment among student cannabis users. Drug and Alcohol Dependence 9: 201–211, 1982.PubMedCrossRefGoogle Scholar
  39. 39.
    Miszzek, K. A. Behavioral effects of chronic marijuana. Psychopharmacology 67:195–201, 1980.Google Scholar
  40. 40.
    Weller, R. A., und Halikas, J. A. Marijuana use and psychiatric illness: A follow-up study. American Journal of Psychiatry 142: 848–850, 1985.PubMedGoogle Scholar
  41. 41.
    Andreasson, S., Allebeck, P., Engstrom, A., und Rydberg, U. Cannabis and schizophrenia: A longitudinal study of Swedish conscripts. Lancet 2:1483–1484, 1987.Google Scholar
  42. 42.
    Szmanzki, H. V. Prolonged depersonalization after marijuana use. American Journal of Psychiatry 138: 231–233, 1981.Google Scholar
  43. 43.
    Schaeffer, J. Cognition and long-term use of ganja. Science 13: 465, 1981.CrossRefGoogle Scholar
  44. 44.
    Brill, N. Q., und Christie, R. L. Marihuana use and psychosocial adaptation. Follow-up study of a collegiate population. Archives of General Psychiatry 31:713–719, 1974.Google Scholar
  45. 45.
    Goodwin, D. W., und Guze, S. B. Psychiatric Diagnosis ( 4th ed. ). New York: Oxford University Press, 1988.Google Scholar
  46. 46.
    Meyer, R. E. Psychiatric consequences of marijuana use. In J. R. Tinklenberg (Ed.), Marijuana and Health Hazards. New York: Academic Press, 1975, pp. 133–152.Google Scholar
  47. 47.
    Spector, I. AMP: A new form of marijuana. Journal of Clinical Psychiatry 46: 498–499, 1985.PubMedGoogle Scholar
  48. 48.
    Campbell, A. M. G., Evans, M., Thomason, J. L. G., Cerebral atrophy in young cannabis smokers. Lancet 2:1219–1224, 1974.Google Scholar
  49. 49.
    Grant, I., und Mohns, L. Chronic cerebral effects of alcohol and drug abuse. International Journal of the Addictions 10: 883–920, 1975.PubMedGoogle Scholar
  50. 50.
    Stefanis, C., Laikos, A., Boulougouris, J., et al. Chronic hashish use and mental disorder. American Journal of Psychiatry 13: 225–227, 1976.Google Scholar
  51. 51.
    Wu, T. C., Tashkin, D. P., Djahed, B., und Rose, J. E. Pulmonary hazards of smoking marijuana as compared with tobacco. New England Journal of Medicine 318: 347–351, 1988.PubMedCrossRefGoogle Scholar
  52. 52.
    Taylor, D. N., Washsmuth, I. K., Shangkuan, Y. H., Salmonellosis associated with marijuana: A multistate outbreak traced by pasmid fingerprinting. New England Journal of Medicine 306:1249–1253, 1982.Google Scholar
  53. 53.
    Dalterio, S., Badr, F., Bartke, A., Cannabinoids in male mice: Effects on fertility and spermatogenesis. Science 216:315–316, 1982.Google Scholar
  54. 54.
    Clapp, J. F., Wesley, M., Cooke, R., The effects of marijuana smoke on gas exchange in ovine pregnancy. Alcohol and Drug Research 7: 85–92, 1986.Google Scholar
  55. 55.
    Smith, C. G., und Asch, R. H. Drug abuse and reproduction. Fertility and Sterility 48: 355–373, 1987.PubMedGoogle Scholar
  56. 56.
    Mendelson, J. H., Ellingboe, J., und Mello, N. K. Acute effects of natural and synthetic cannabis compounds on prolactin levels in human males. Pharmacology, Biochemistry and Behavior 20:103-106, 1984.Google Scholar
  57. 57.
    Heath, R. G. Cannabis: Effects on brain function and ultrastructure. Biological Psychiatry 15:657-690, 1980.Google Scholar
  58. 58.
    Bier, M. M., und Steahly, L. P. Emergency treatment of marihuana complicating diabetes. In P. G. Boume (Ed.), A Treatment Manual for Acute Drug Abuse Emergencies. Washington, D.C.: U.S. Government Printing Office, 1974, pp. 88–94.Google Scholar
  59. 59.
    Fortenberry, J. C., Brown, D. B., und Shevlin, L. T. Analysis of drug involvement in traffic fatalities in Alabama. American Journal of Drug and Alcohol Abuse 12: 257–267, 1986.PubMedCrossRefGoogle Scholar
  60. 60.
    Yesavage, J. A., Leiner, V. O., Denari, M., und Hollister, L. E. Carryover effects of marijuana intoxication on aircraft pilot performance: A preliminary report. American Journal of Psychiatry 142:1325–1329, 1985.Google Scholar
  61. 61.
    Sutton, L. The effects of alcohol, marihuana and their combination on driving ability. Journal of Studies on Alcohol 44: 438–445, 1983.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Marc A. Schuckit
    • 1
  1. 1.San Diego School of Medicine, Veterans Administration HospitalUniversity of CaliforniaSan DiegoUSA

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