H-2 Antigens pp 837-845 | Cite as

Immune Recognition of Human MHC DR2 Antigen

  • M. Zouhair Atassi
  • Hammad Atassi
  • Robert G. Ulrich
Part of the NATO ASI Series book series (NSSA, volume 144)


The human class II major histocompatibility complex (MHC) antigens are homologues of the murine Ia antigens. Class II HLA glycoproteins have a limited tissue distribution, being found primarily on the macrophage, dendrite cells, B cells and activated T cells, but they may also be induced on other cell types by interferon-γ (Pober et al, 1983). Class II HLA antigens are composed of a dimer of a heavy (33–35 kDa) a chain and a light (27–29 kDa) B chain (Shackelford et al., 1981). Both the a and B subunits are composed of two extracellular domains, each containing a disulfide loop, with the exception of the N-terminal domain of the a chain. Allelic polymorphism is a characteristic of the B chains of DP and DR (Goyert et al., 1982; van Rood et al., 1976; Giles and Capra, 1985) and of both chains of the DQ molecules (Giles and Capra, 1985; Giles et al., 1985).


Major Histocompatibility Complex Antigenic Site Major Histocompatibility Complex Protein Major Histocompatibility Complex Restriction Disulfide Loop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • M. Zouhair Atassi
    • 1
    • 2
  • Hammad Atassi
    • 1
  • Robert G. Ulrich
    • 2
  1. 1.Department of BiochemistryBaylor College of MedicineHoustonUSA
  2. 2.Department of Microbiology, ImmunologyBaylor College of MedicineHoustonUSA

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