Immune Recognition of Human MHC DR2 Antigen
The human class II major histocompatibility complex (MHC) antigens are homologues of the murine Ia antigens. Class II HLA glycoproteins have a limited tissue distribution, being found primarily on the macrophage, dendrite cells, B cells and activated T cells, but they may also be induced on other cell types by interferon-γ (Pober et al, 1983). Class II HLA antigens are composed of a dimer of a heavy (33–35 kDa) a chain and a light (27–29 kDa) B chain (Shackelford et al., 1981). Both the a and B subunits are composed of two extracellular domains, each containing a disulfide loop, with the exception of the N-terminal domain of the a chain. Allelic polymorphism is a characteristic of the B chains of DP and DR (Goyert et al., 1982; van Rood et al., 1976; Giles and Capra, 1985) and of both chains of the DQ molecules (Giles and Capra, 1985; Giles et al., 1985).
KeywordsMajor Histocompatibility Complex Antigenic Site Major Histocompatibility Complex Protein Major Histocompatibility Complex Restriction Disulfide Loop
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