Expression of H-2 Genes and Susceptibility to Parasitic Infection
The term parasitism is difficult to define. Many infectious organisms such as bacteria or fungi, live at the expense of their hosts, yet are not usually regarded as parasites. In contrast, certain protozoans or helminths which live in close association with their hosts, but cause no demonstrable disease, are called parasites nonetheless. For present purposes, the discussion of immunity to parasites will be restricted to immune responses induced in vertebrate hosts following exposure to protozoan, helminth, or arthropod “parasites”. While such a distinction is arbitrary, it follows conventional practice. Following a brief discussion of immunity to parasitic infections in very general terms, results from studies of Trichinella spiralis-infected mice will be reviewed to provide specific examples of how H-2 genes may influence the outcome of such host-parasite interactions.
KeywordsParasitic Infection Adult Worm Female Worm Express Cell Surface Recombinant Tumor Necrosis Factor
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