Abstract
In the course of mapping H–2–linked genes which control susceptibility to cortisoneinduced cleft palate, we have observed that certain pairs of congenic strains which have been considered to have the same H–2–recombinant chromosomes differ in their susceptibility. The B10.A(1R) and B10.A(2R) congenic strains have been believed to possess the same a/b crossover in the S/D interval, but B10.A(2R) is significantly more susceptible than B10.A(1R). Likewise, the B10.A(18R) and B10.BAR5 strains have been considered to have the same b/a crossover in the S/D interval, but B10.BAR5 is significantly more susceptible than B10.A(18R). In order to assess the possible effects of these genes on susceptibility to other steroids, we have injected pregnant mice on days 11 through 14 with testosterone. We have observed significant differences among H-2 congenic strains in the frequency of testosterone-induced fetal resorption. Among surviving fetuses, there were significant differences in the frequency of testosterone-induced cleft palate.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Biddle, F.G. And Fraser, F.C.: Cortisone-induced cleft palate in the mouse. A search for the genetic control of the embryonic response trait. Genetics 85: 289–302, 1977
Bonner, J.J. and Slavkin, H.C.: Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouse. Immunogenetics 2: 213–218, 1975
Bonner, J.J. and Tyan, M.L.: Glucocorticoid-induced cleft palate genes in chromosome 17: Genetic linkage and mapping analyses. Immunogentics 20: 169–183, 1984
Cato, A.C.B., Henderson, D. and Ponta, H.: The hormone response element of the mouse mammary tumor virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region. EMBO Journal 6: 363 — 368, 1987
Darbre, P., Page, M. and King, R.J.B.: Androgen regulation by the long terminal repeat of mouse mammary tumor virus. Mol. Cell Biol. 6: 2847 — 2854, 1986
Demant, P.: Corticosteroid-induced cleft palate: Cis interaction of MHC genes and hybrid resistance. Immunogenetics 22: 183–188, 1985
Dlouhy, S.R., Taylor, B.A. and Karn, R.C.: The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromsome 7. Genetics 115: 535 — 543, 1987
Francke, V. and Gehring, U.: Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Cell 22: 657 — 664, 1980
Gasser, D.L. and Goldman, A.S.: Genetic and biochemical studies on glucocorticoid-induced cleft palate. Biochemical Actions of Hormones 10: 357 — 382, 1983
Gasser, D.L., Mele, L., Lees, D.D. and Goldman, A.S.: Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromsomes 2 and 17. Proc. Natl. Acad. Sci. USA 78: 3147–3150, 1981
Goldman, A.S. and Katsumata, M.: Murine glucocorticoid receptors: New evidence for a discrete receptor influenced by H-2. Arch. Biochem. Biophys. 249: 316–325, 1986
Gregorova, S. and Ivanyi, P.: H-2-Associated genetic differences in androgen-dependent traits. The effect of testosterone injections. Foila biologica 19: 337–345, 1973
Haseman, J.K. and Hogan, M.D.: Selection of the experimental unit in teratology studies. Teratology 12: 165–172, 1975
Ivanyi, P., Gregorova, S. and Mickova, M.: Genetic differences in thymus, lymph node, testes and vesicular gland weight among inbred mouse strains. Association with the major histocompatibility (H-2) system. Foila biologica 18: 81–97, 1972a
Ivanyi, P., Hampl, R., Starka, L. and Mickova, M.: Genetic association between H-2 gene and testosterone metabolism in mice. Nature New Biology 238: 280–281, 1972b
Klein, J., Flaherty, L., VandeBerg, J.L. and Shreffler, D.C.: H-2 haplotypes, genes, regions and antigens: First listing. Immunogenetics 6: 489–512, 1978
Lafuse, W. and Edidin, M.: Influence of the major histocompatibility complex, H-2, on liver adenylate cyclase activity and on glucagon binding to liver cell membranes. Biochemistry 19: 49–54, 1980
Litwack, G. and Rosenfield, S.A.: Liver cytosol corticosteroid binder IB, a new binding protein. J Biol. Chem. 250: 6799–6805, 1975
Meruelo, D. and Edidin, M.: The biological function of the major histocompatibility complex: Hypotheses. Contemp. Topics Immunobiol 9: 231–253, 1980
Tyan, M.L. and Miller, K.K.: Genetic and environmental factors in cortisone-induced cleft palate. Proc. Soc. Exp. Biol. Med. 158: 618–621, 1978
Warner, C.M., Gollnick, S.O. and Goldbard, S.B.: Linkage of the Preimplantation-Embryo-Development (Ped) gene to the mouse major histocompatibility complex (MHC). Biol. Reprod. 36: 606–610, 1987
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Science+Business Media New York
About this chapter
Cite this chapter
Gasser, D.L., Gupta, C., Goldman, A.S. (1987). H-2-linked Control of the Susceptibility of Mice to Cleft Palate Induced by Cortisone and Testosterone. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_69
Download citation
DOI: https://doi.org/10.1007/978-1-4757-0764-9_69
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-0766-3
Online ISBN: 978-1-4757-0764-9
eBook Packages: Springer Book Archive