Abstract
Spontaneous reticulum cell sarcoma (RCS) tumors arise spontaneously in SJL/J mice between the ages of 8–12 months. Since its original description by Murphy (1963) several studies have been undertaken to investigate this unusual tumor that expresses several unique properties. A general description of this tumor system has been recently reviewed (Bonavida, 1983, 1985). The most prominent features of this tumor are characteristics not shared by other studied tumor systems i.e. the RCS tumor expresses inappropriate Ia antigens on the surface, it stimulates syngeneic T cells to proliferate both in vivo and in vitro, and its growth is dependent on host T cells and on both the MHC and non-MHC genetic background of the host mouse. The tumor is difficult to establish in culture and only a few spontaneous tumors can be transplanted in syngeneic hosts and become transplantable lines.
Acknowledgement: This work was supported in part by grant CA19753 from the National Cancer Institute, DHHS and in part by a gift from Chugai Pharmaceuticals, Japan.
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Bonavida, B., Ohnishi, K. (1987). Host-RCS Tumor Interactions in SJL/J Mice. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_67
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_67
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