H-2 Antigens pp 651-657 | Cite as

Regulation of H-2 Class I Gene Expression in Virus Transformed and/or Infected Cells

  • Daniel Meruelo
Part of the NATO ASI Series book series (NSSA, volume 144)


Our group first documented that viral infections and virus-induced transformations can significantly affect class I gene expression. These virally-induced alterations in H-2 (class I) antigen expression were shown to play a striking role in resistance to neoplasia18. Similar observations which have recently been made by numerous investigators in a variety of other systems 6, 8, 12, 24, 26.


Antigen Expression Viral Sequence Histocompatibility Antigen Susceptible Mouse Resistant Mouse 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Daniel Meruelo
    • 1
  1. 1.Department of Pathology and Kaplan Cancer CenterNew York University Medical CenterNew YorkUSA

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