Altered MHC Class I Genes Can Encode Immunogenic Antigens that Cause Tumor Rejection
The C3H UV—induced skin tumor 1591 is highly immunogenic and is rejected when transplanted into immunocompetent syngeneic C3H mice. We have isolated three MHC class I genes from a genomic tumor library and we show that these genes encode novel class I antigens expressed in 1591 tumor cells but not in normal C3H cells. All three genes account for a restriction fragment length polymorphism in the tumor DNA relative to normal C3H DNA, indicating that the genes were not preexistant in the C3H genome but arose by mutation or recombination. We show that one of the tumor class I genes encodes a highly immunogenic class I antigen which is a target antigen for tumor rejection in immunocompetent hosts.
KeywordsTumor Rejection Progressor Variant Restriction Fragment Length Polymorphism Immunogenic Antigen Aminoglycoside Phosphotransferase
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