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The Biological Implications of the Abnormal Expression of Histocompatibility Antigens on Murine and Human Tumors

  • Chapter
Book cover H-2 Antigens

Part of the book series: NATO ASI Series ((NSSA,volume 144))

Abstract

There is increasing evidence indicating that the expression of histocompatibility antigens is altered in experimental tumors induced in mice as well as in human tumors (1,2,). Two different types of alterations have been described:

  1. a)

    Total or selective loss of class I molecules (K,D,L or HLA, A,B,C) whose reexpression can in most cases be induced after γIFN treatment. Examples of this are absence of the Kk molecule of Gardner lymphoma (3) or the disappearence of four H-2d antigenic specificities on an H-2d sarcoma (4).

  • These losses may represent an escape route from T cell immunosurveillance or a mechanism to induce UK sensitive tumor targets, (19).

  1. b)

    The appearance of aberrant class I like molecules which may behave like alloantigens and are capable of triggering an immune response like that seen in allograft rejection (5,6). The aberrant molecules on these clones may be tumor associated transplantation antigen (TATA).

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Author information

Authors and Affiliations

  1. Servicio Análisis Clínicos, Hospital Virgen de las Nieves, 18014, Granada, Spain

    Federico Garrido

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  1. Federico Garrido
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  1. Mayo Clinic, Rochester, Minnesota, USA

    Chella S. David Ph.D.

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Garrido, F. (1987). The Biological Implications of the Abnormal Expression of Histocompatibility Antigens on Murine and Human Tumors. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_60

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  • DOI: https://doi.org/10.1007/978-1-4757-0764-9_60

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0766-3

  • Online ISBN: 978-1-4757-0764-9

  • eBook Packages: Springer Book Archive

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