MHC Antigen Expression in Malignant Tumours and Their Effects on Host-Tumour Interaction
The development of malignant tumours and their immune regulation depends on a variety of factors including the presence or absence of tumour cell associated antigens (TAA) and the quantitative and qualitative representation of major histocompatibility complex (MHC) determinants in the tumour cells. Investigations of the latter and their importance in relation to host tumour interaction has been the main thrust of our research in this area over the last ten years. Increased or decreased expression of syngeneic Class I and Class II molecules as well as the expression of aberrant “allospecificities” may in different ways affect the immunosurveillance of tumours, their growth rate, as well as their metastatic potential. Our original experimental findings included the observations that certain tumour cells (a) selectively fail or express very weakly the specificities of one of the syngeneic H-2 Class I loci and/or (b) express novel H-2 “allospecificities” as determined by antibody testing.
KeywordsMajor Histocompatibility Complex Gene Major Histocompatibility Complex Antigen Neuraminidase Treatment Syngeneic Tumour Major Histocompatibility Complex Antigen Expression
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