Do Class II Major Histocompatibility Molecules Function as Signal Transducers during B Lymphocyte Activation?
The studies described here address the hypothesis that class II molecules (Ia) serve not only as restriction elements for cognate T cell:B cell interaction, but also as signal transducers involved in B cell activation. We have tested this hypothesis by studying modulation of B cell physiology by anti-Ia antibodies. Specifically, we have assessed the ability of these antibodies to induce “second” messenger generation and to modulate cell proliferative and differentiative responses to LPS and anti IgM antibodies.
KeywordsAdenylate Cyclase None None Cellular cAMP cAMP Generation Cell Surface Signal Transduction
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