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H-2 Antigens pp 441-449 | Cite as

Recognition of MHC Class II Antigens by the CD4: T Cell Receptor Complex

  • Charles A. JanewayJr.
  • Pilar Portoles
  • John P. Tite
  • Jose Rojo
  • Kaj Saizawa
  • Barry Jones
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

T lymphocytes that express CD4 respond to foreign antigens presented in the context of syngeneic class II MHC molecules. T cells responding to allogeneic class II MHC molecules generally express CD4, but exceptions are observed. We show that the same receptor on a cloned T cell line recognizes both foreign antigen associated with self-class II MHC and nonself-class II MHC molecules. The role of CD4 in these recognition responses appears to be to bind to class II MHC molecules and, through association with the T cell receptor recognizing the same class II MHC molecule, to effectively activate the T cell. It is proposed on the basis of these two findings that the high ligand multiplicity of alloantigens recognized in unmodified form by high affinity anti-nonself-MHC receptors can explain the finding of CD8+ T cells responding to nonself-class II MHC molecules, as well as the inability of anti—CD4 to inhibit such nonself-class II MHC recognition completely. Finally, data will be presented to suggest that class II may also play a role in selecting the functional activity elicited in response to a protein antigen in vivo. These data show that the CD4:T cell receptor complex interaction with the complex of foreign antigen and self-MHC is the critical event in initiating most immune responses and may also play a role in controlling their functional outcome.

Keywords

Cell Receptor Foreign Antigen Recognition Response Howard Hughes Medical Institute Clonal Selection Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Charles A. JanewayJr.
    • 1
  • Pilar Portoles
    • 1
  • John P. Tite
    • 1
  • Jose Rojo
    • 1
  • Kaj Saizawa
    • 1
  • Barry Jones
    • 1
  1. 1.Section of Immunobiology and Department of PathologyHoward Hughes Medical Institute at Yale University School of MedicineNew HavenUSA

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