Abstract
Successfully implanted islets of Langerhans between two H-2 disparate strains are rejected following injection of cells bearing class I antigens syngeneic to the graft, together with either syngeneic or allogeneic class II antigens. Such rejection does not occur if class II syngeneic to the graft, but class I antigens are not.
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Reference
Agostino, M., Prowse, S.J., and Lafferty, K.J. Induction of tolerance using ultraviolet-irradiated cells. Transplantation Proceedings, Vol. XVI: 959–960, 1984.
Baekkeskov, S., Lernmark, A., Klareskog, L. Presence of transplantation antigens in pancreatic islets. Diabetologia 19: 255, 1980.
Bowen, K., Prowse, S., Lafferty, K. Reversal of diabetes by islet transplantation: Vulnerability of the established allograft. Science 213: 1261–1262, 1981.
Caughman, S.W., Sharrow, S.O., Shimada, S., Stephany, D., Mizuochi, T., Rosenberg, A.S., Katz, S.I. and Singer, A. Ia+ murine epidermal Langerhans cells are deficient in surface expression of the class I major histocompatibility complex. Proc. Natl. Acad. Sci. USA 83: 7438–7442, 1986.
Donohoe, J.A., Andrus, L., Bowen, K.M., Simeonovic, C., Prowse, S.J., Lafferty, K.J. Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice. Transplantation 35: 62–67, 1983.
Fausturan, D., Hauptfeld, V., Davie, J.M., Lacy, P.E. and Shreffler, D.C. Murine pancreatic 8-cells express H-2K and H-2D but not Ia antigens. J. Exp. Med. 151: 1563–1568, 1980.
Faustman, D., Hauptfeld, V., Lacy, P.E. and Davie, J.M. Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants. Proc. Natl. Acad. Sci. USA 78: 5156–5159, 1981.
Faustman, D.L., Steinman, R.M., Gebel, H.M., Hauptfeld, V., Davie, J.M., and Lacy, P. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc. Natl. Acad. Sci. USA 81: 3864–3868, 1984.
Faustman, D.L., Hauptfeld, V., Davie, J.M., and Lacy, P.E. Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants. Transplantation 40: 216–218, 1985.
Faustman, D., Lacy, P., Davie, J., and Hauptfeld, V. Prevention of allograft rejection by immunization with donor blood depleted of Iabearing cells. Science 217: 1570158, 1982.
Lacy, P., Davie, J., Finke, E. Prolongation of islet allograft survival following in vitro culture (24°C) and a single injection of ALS. Science 204: 312–313, 1979.
Lacy, P., Davie, J., Finke, E. Induction of rejection of successful allograft of rat islets by donor peritoneal exudate cells. Transplantation 28: 415–420, 1979.
Lacy, P.L. and Kostianovsky, M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16: 35–39, 1967.
Lafferty, K., Cooley, M., Woolnough, J., Walker, K. Thyroid allograft immunogenicity is reduced after a period in organ culture. Science 188: 259–261, 1975.
Lauchart, W., Alkins, B.J., Davies, D.A.L. Only B lymphocytes induce active enhancement of rat cardial allografts. Transplantation 29: 259–261, 1980.
Lindall, A., Steffes, M., Sorenson, R. Immunoassayable insulin content of sùbcellular fractions of rat islets. Endocrinology 85: 218, 1969.
Minami, M., Shreffler, D.C. and Cowing, C. Characterization of the stimulator cell in the murine primary mixed leucocyte response. J. Immunology 124: 1314–1321, 1980.
Mizuochi, T., Golding, H., Rosenberg, A.S., Glimcher, L.H., Malek, T.R., and Singer, A. Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogeneic major histocompatibility antigens but not against trinitrophenyl-modified self. J. Exp. Med. 162: 427–443, 1985.
Morrow, C.E., Sutherland, D.E.R., Steffers, M.W., Najarian, J.S. and Bach, F.H. Lack of donor-specific tolerance in mice with established anti-Ia-treated islet allografts. Transplantation 36: 691–694, 1983.
Morrow, C.E., Sutherland, D.E.R., Steffes, M.W., Najarian, J.S. and Bach, F.H. H-2 antigen class: Effect on mouse islet allograft rejection. Science 219: 1337–1339, 1983.
Okazaki, H., Maki, T., Wood, M.L., Jones, S. and Monaco, A.P. Prolongation of skin allograft survival in H-2 K and I region-incompatibile mice by pretransplant blood transfusion. Transplantation 32: 111–115, 1981.
Sollinger, H., Burkholder, P., Rasmus, W., Bach, F. Prolonged survival of xenografts after organ culture. Surgery 81: 74–79, 1977.
Zitron, I.M., Ono, J., Lacy, P.E. and Davie, J.M. The cellular stimuli for the rejection of established islet allografts. Diabetes 30: 242–246, 1981.
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Hauptfeld, V., Faustman, D., Terasaka, R., Lacy, P.E., Shreffler, D.C. (1987). Genetic Control of Interaction Between Class I and Class II Antigens in Murine Islet Rejection. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_42
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_42
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