Role of MHC Class I Antigens in Tumor Rejection
The mouse H-2 or major histocompatibility complex (MHC) encodes a series of antigens that are centrally involved in immune responses. The K and D MHC class I antigens are highly polymorphic glycoproteins expressed on the surface of most nucleated cells, and consist of a 45 KD heavy chain noncovalently associated with a 12 KD protein, beta-2-microglobulin (B2m). Genetic differences between MHC class I antigens of graft donor and recipient result in allogeneic graft rejection. MHC class I antigens are also required for T cell mediated recognition of virally infected (Zinkernagel and Doherty 1979) or modified self cells (Shearer 1974).
KeywordsMajor Histocompatibility Complex Antigen Expression Tumor Rejection Teratocarcinoma Cell Major Histocompatibility Complex Antigen
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