Abstract
The preimplantation period of development is crucial for the survival of mammalian species. During this time the fertilized egg goes through a series of cleavage divisions and cell differentiation events leading to blastocyst formation. Only then can the embryo implant in the uterus and continue its development. We have discovered a gene, Ped, Preimplantation embryo development, linked to the H-2 complex, which influences the rate of early mouse embryo development. The Ped gene maps to the Q region of the H-2 complex. Moreover, concordance of expression of the fast Ped allele with the presence of Qa-2 antigens on preimplantation embryos, and concordance of expression of the slow Ped allele with the absence of Qa-2 antigens on preimplantation embryos, have been found. On the basis of these results we have hypothesized that the Ped gene product may be the Qa-2 antigen.
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Warner, C.M. (1987). An H-2 Linked Gene, PED, Influences the Timing of Early Mouse Embryo Development. In: David, C.S. (eds) H-2 Antigens. NATO ASI Series, vol 144. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0764-9_36
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DOI: https://doi.org/10.1007/978-1-4757-0764-9_36
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