An H-2 Linked Gene, PED, Influences the Timing of Early Mouse Embryo Development
The preimplantation period of development is crucial for the survival of mammalian species. During this time the fertilized egg goes through a series of cleavage divisions and cell differentiation events leading to blastocyst formation. Only then can the embryo implant in the uterus and continue its development. We have discovered a gene, Ped, Preimplantation embryo development, linked to the H-2 complex, which influences the rate of early mouse embryo development. The Ped gene maps to the Q region of the H-2 complex. Moreover, concordance of expression of the fast Ped allele with the presence of Qa-2 antigens on preimplantation embryos, and concordance of expression of the slow Ped allele with the absence of Qa-2 antigens on preimplantation embryos, have been found. On the basis of these results we have hypothesized that the Ped gene product may be the Qa-2 antigen.
KeywordsPreimplantation Embryo Congenic Mouse Preimplantation Development Preimplantation Mouse Embryo Preimplantation Embryo Development
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