A Q Region Product as a CTL Restriction Element?
The function of class I genes mapping in the Q and TL regions of the MHC is unknown. Data presented in this study will show that two genes control a determinant (Qc-1) recognized by cloned cytotoxic T lymphocytes (CTL). One gene is a class I gene and maps in the Q region. The second gene maps in the K-end of the MHC and has tentatively been mapped between A ß3 and A ß2 with recombinant strains. Monoclonal antibody reactive with Q region encoded class I molecules blocks CTL recognition of the Qc-1 determinant at the target cell level. An attractive interpretation of these data is that the Q region class I molecule serves as a CTL restriction element for the recognition of a K-end encoded peptide.
KeywordsSpleen Cell Recombinant Strain Region Class Restriction Element Cytolytic Assay
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