H-2 Antigens pp 341-358 | Cite as

Historical Developments in Understanding the Function of Class I MHC Genes

  • Peter C. Doherty
Part of the NATO ASI Series book series (NSSA, volume 144)


It is reasonable to state that, as late as 1973, the reason for the existence and extraordinary polymorphism of the strong transplantation antigens (now known as the class I MHC glycoproteins) was not understood (Amos et al., 1971; Bodmer, 1972). Two sets of facts were undisputed: that the allograft response was extremely potent, and that the frequency of effector T cells specific for foreign transplantation antigens was very high (Simonsen, 1967; Wilson, et al., 1968). This had led to a variety of speculations, a few of the more perceptive of which are listed in Table 1.


Major Histocompatibility Complex Major Histocompatibility Complex Molecule Major Histocompatibility Complex Gene Histocompatibility Antigen Lymphocytic Choriomeningitis 
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© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Peter C. Doherty
    • 1
  1. 1.Department of Experimental PathologyThe John Curtin School Medical ResearchCanberraAustralia

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