Advertisement

H-2 Antigens pp 305-314 | Cite as

Probing MHC DNA in Search of Coding Sequences: Detection of a Novel Gene Located Between C4 and Bf in Mouse and Man

  • Matthieu Lévi-Strauss
  • Michael Carroll
  • Michael Steinmetz
  • Tommaso Meo
Part of the NATO ASI Series book series (NSSA, volume 144)

Abstract

The search for specific genes in chromosomal regions implicated in particular diseases or associated with certain functions is one of the approaches that may lead to a molecular analysis of inherited albeit biochemically ill defined traits. This strategy is presently pursued to understand the mechanism of some genetically determined diseases such as the Duchenne Muscular Dystrophy (Monaco et al., 1986).

Keywords

Major Histocompatibility Complex Duchenne Muscular Dystrophy Cosmid Clone Human Major Histocompatibility Complex Transcriptional Orientation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amor, M., Tosi, M., Duponchel, C., Steinmetz, M., and Mea, T.: Liver mRNA probes disclose two cytochrome P-450 genes duplicated in tandem with the complement C4 loci of the mouse H-2S region. Proc. Natl. Acad. Sci. USA 82: 4453, 1985Google Scholar
  2. Bird, A.P.: CpG-rich islands and the function of DNA methylation. Nature 321: 209, 1986Google Scholar
  3. Burke, T., and Bruford, M.W.: DNA fingerprinting in birds. Nature 327: 149, 1987Google Scholar
  4. Carroll, M.C., Campbell, R.D., Bentley, D.R., and Porter, R.R.: A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307: 237, 1984Google Scholar
  5. Chaplin, D., Woods, D., Whitehead, A., Goldberger, G., Colten, H.R., and Seidman, J.G.: Molecular map of the murine S region. Proc. Natl. Acad. Sci. USA 80: 6947, 1983Google Scholar
  6. Estivill, X., Farrall, M., Scambler, P.J., Bell, G.M., Hawley, K.M.F., Lench, N.J., Bates, G.P., Kruger, H.C., Frederick, P.A., Stanier, P., Watson, E.K., Williamson, R., and Wainwright, B.S.: A candidate for the cystic fibrosis locus isolated by selection for methylationfree islands. Nature 326: 840, 1987Google Scholar
  7. Feinberg, A.P., and Vogelstein, B.: A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Analytical Biochemistry 132: 6, 1983Google Scholar
  8. Friend, S.H., Bernards, R., Rogelj, S., Weinberg, R.A., Rappaport, J.M., Albert, D.M., and Dryja, T.P.: A human DNA segment with properties of the gene that predisposes to retinoblastoma and oasteosarcoma. Nature 323: 643, 1986Google Scholar
  9. Grosveld, F.G., Lund, T., Murray, E.J., Mellor, A.L., Dahl, H.H.M., and Flavell, R.A.: The construction of cosmid libraries which can be used to transform eukaryotic cells. Nucl. Ac. Res. 10: 6715, 1982Google Scholar
  10. Jeffreys, A.J., Wilson, V., and Thein, S.L.: Hypervariable “minisatellite” regions in human DNA. Nature 314: 67, 1985Google Scholar
  11. Juji, T., Satake, M., Honda, Y., and Doi, Y.: HLA antigens in Japanese patients with narcolepsy. Tissue Antigens 24: 316, 1984Google Scholar
  12. Lemonnier, F.A., Malissen, M., Goldstein, P., Le Bouteiller, P., Rebai, N., Damotte, M., Birnbaum, D., Caillol, D., Trucy, J., and Jordan, B.R.: Expression of human class I histocompatibility antigens at the surface of DNA transformed mouse L cells. Immunogenetics 16: 355, 1982Google Scholar
  13. Lévi-Strauss, M., Tosi, M., Steinmetz, M., Klein, J., and Meo, T.: Multiple duplications of complement C4 gene correlate with H-2 controlled testosterone-independent expression of its sex-limited isoform, C4-Slp. Proc. Natl. Acad. Sci. USA 82: 1746, 1985aGoogle Scholar
  14. Lévi-Strauss, M., Georgatsou, E., Tosi, M., and Meo, T.: Gene-specific probes demonstrate selective duplications of the C4-Slp gene. Immunogenetics 21: 397, 1985bGoogle Scholar
  15. Lindsay, S., and Bird, A.P.: Use of restriction enzymes to detect potential gene sequences in mammalian DNA. Nature 327: 336, 1987Google Scholar
  16. Mallat, M., Moura Neto, V., Gros, F., Glowinski, J., and Prochiantz, A.: Two simian virus 40 (SV40) transformed cell lines from the mouse striatum and mesencephalon presenting astrocytes characters. II: Interaction with mesencephalic neurons. Dev. Brain Res. 26: 23, 1986Google Scholar
  17. Monaco, A.P., Neve, R.L., Colletti-Feener, C., Bertelson, C.J., Kurnit, D.M., and Kunkel, L.M.: Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene. Nature 323: 646, 1986Google Scholar
  18. Miller, U., Stephan, D., Philippsen, P., and Steinmetz, M.: Orientation and molecular map position of the complement genes in the mouse MHC. EMBO J. 6: 369, 1987Google Scholar
  19. Parker, K.L., Chaplin, D.D., Wong, M., Seidman, J.G., Smith, J.A., and Schimmer, B.P.: Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells. Proc. Natl. Acad. Sci. USA 82: 7860, 1985Google Scholar
  20. Simon, M., Fauchet, R., Hespel, J.P., Beaumont, C., Brissot, P., Hita de Nercy, Y., Genetet, B., and Bourel, M.: Idiopathic homochromatosis, a study of biochemical expression in 247 heterozygous members of 63 families. Evidence for a single major HLA-linked gene. Gastroenterology 78: 703, 1980Google Scholar
  21. Steimetz, M., Malissen, M., Hood, L., Orn, A., Maki, R.A., RezaDastoornikoo, G., Stephan, D., Gibb., E., and Romaniuk, R.: Tracts of high or low sequence divergence in the mouse major histocompatibility complex. EMBO J. 3: 2995, 1984Google Scholar
  22. Tosi, M., Lévi-Strauss, M., Georgatsou, E., Amor, M., and Meo, T.: Duplications of complement and non complement genes of the H-2S region: evolutionary aspects of C4 isotypes and molecular analysis of their expression variants. Immunological Reviews 87: 151, 1985Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Matthieu Lévi-Strauss
    • 1
  • Michael Carroll
    • 2
  • Michael Steinmetz
    • 3
  • Tommaso Meo
    • 1
  1. 1.INSERM U 276 and Unité d’ImmunogénétiqueInstitut PasteurParisCedex 15France
  2. 2.Harvard Medical SchoolBostonUSA
  3. 3.Basel Institute for ImmunologyBaselSwitzerland

Personalised recommendations