Biochemical and Molecular Characterization of Q-Region Class I Gene Products
Telomeric to the H2D region is a chromosomal segment which encodes several serologically and/or biochemically defined class I molecules (1). These include the cell surface molecules Qal, Qa2 and TL and the soluble proteins Qbl and Q10 (2–4). Although related to H2-K, -D, -L molecules by subunit structure and primary sequence, the Qa/TL molecules are biologically distinct. For example, Qa/TL molecules display distinct tissue specific regulated expression, are relatively nonpolymorphic (conserved ?) and appear not to be utilized as restricting elements in T cell recognition. Although their class I counterparts H2-K, -D and -L have well defined roles in tissue/organ transplantation and T cell recognition of foreign antigens, the function(s) of the Qa/TL class I proteins remains obscure.
KeywordsMajor Histocompatibility Complex Decay Accelerate Factor Transplantation Antigen Lipase Treatment Detergent Phase
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